北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第二临床医学院  > 消化内科  > 期刊论文
学科主题: 临床医学
题名:
Dysbiosis Signature of Fecal Microbiota in Colorectal Cancer Patients
作者: Wu, Na1; Yang, Xi1; Zhang, Ruifen1; Li, Jun2; Xiao, Xue1; Hu, Yongfei1; Chen, Yanfei3; Yang, Fengling3; Lu, Na1; Wang, Zhiyun1; Luan, Chunguang1; Liu, Yulan4; Wang, Baohong3; Xiang, Charlie3; Wang, Yuezhu6; Zhao, Fangqing5; Gao, George F.1; Wang, Shengyue6; Li, Lanjuan3; Zhang, Haizeng2; Zhu, Baoli1
刊名: MICROBIAL ECOLOGY
发表日期: 2013-08-01
DOI: 10.1007/s00248-013-0245-9
卷: 66, 期:2, 页:462-470
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Ecology ; Marine & Freshwater Biology ; Microbiology
研究领域[WOS]: Environmental Sciences & Ecology ; Marine & Freshwater Biology ; Microbiology
关键词[WOS]: BACTEROIDES-FRAGILIS ENTEROTOXIN ; INTESTINAL EPITHELIAL-CELLS ; HUMAN GUT MICROBIOTA ; NF-KAPPA-B ; ENTEROCOCCUS-FAECALIS ; WIDE ASSOCIATION ; EXPRESSION ; ACTIVATION ; SECRETION ; ETIOLOGY
英文摘要:

The human gut microbiota is a complex system that is essential to the health of the host. Increasing evidence suggests that the gut microbiota may play an important role in the pathogenesis of colorectal cancer (CRC). In this study, we used pyrosequencing of the 16S rRNA gene V3 region to characterize the fecal microbiota of 19 patients with CRC and 20 healthy control subjects. The results revealed striking differences in fecal microbial population patterns between these two groups. Partial least-squares discriminant analysis showed that 17 phylotypes closely related to Bacteroides were enriched in the gut microbiota of CRC patients, whereas nine operational taxonomic units, represented by the butyrate-producing genera Faecalibacterium and Roseburia, were significantly less abundant. A positive correlation was observed between the abundance of Bacteroides species and CRC disease status (R = 0.462, P = 0.046 < 0.5). In addition, 16 genera were significantly more abundant in CRC samples than in controls, including potentially pathogenic Fusobacterium and Campylobacter species at genus level. The dysbiosis of fecal microbiota, characterized by the enrichment of potential pathogens and the decrease in butyrate-producing members, may therefore represent a specific microbial signature of CRC. A greater understanding of the dynamics of the fecal microbiota may assist in the development of novel fecal microbiome-related diagnostic tools for CRC.

语种: 英语
所属项目编号: 2009CB522605 ; 81021003 ; 2011-4022-06
项目资助者: National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China (NSFC) ; The Capital Health Research and Development of Special
WOS记录号: WOS:000321668900020
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52285
Appears in Collections:北京大学第二临床医学院_消化内科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Chinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol, Beijing 100101, Peoples R China
2.Chinese Acad Med Sci, Canc Inst & Hosp, Dept Abdominal Surg Oncol, Beijing 100021, Peoples R China
3.Zhejiang Univ, Affiliated Hosp 1, State Key Lab Diag & Treatment Infect Dis, Hangzhou 310003, Zhejiang, Peoples R China
4.Peking Univ, Peoples Hosp, Dept Gastroenterol, Beijing 100044, Peoples R China
5.Chinese Acad Sci, Beijing Inst Life Sci, Beijing 100101, Peoples R China
6.Chinese Natl Human Genome Ctr Shanghai, Shanghai 201203, Peoples R China

Recommended Citation:
Wu, Na,Yang, Xi,Zhang, Ruifen,et al. Dysbiosis Signature of Fecal Microbiota in Colorectal Cancer Patients[J]. MICROBIAL ECOLOGY,2013,66(2):462-470.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Wu, Na]'s Articles
[Yang, Xi]'s Articles
[Zhang, Ruifen]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Wu, Na]‘s Articles
[Yang, Xi]‘s Articles
[Zhang, Ruifen]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace