IR@PKUHSC  > 北京大学第二临床医学院  > 消化科
学科主题临床医学
Dysbiosis Signature of Fecal Microbiota in Colorectal Cancer Patients
Wu, Na1; Yang, Xi1; Zhang, Ruifen1; Li, Jun2; Xiao, Xue1; Hu, Yongfei1; Chen, Yanfei3; Yang, Fengling3; Lu, Na1; Wang, Zhiyun1; Luan, Chunguang1; Liu, Yulan4; Wang, Baohong3; Xiang, Charlie3; Wang, Yuezhu6; Zhao, Fangqing5; Gao, George F.1; Wang, Shengyue6; Li, Lanjuan3; Zhang, Haizeng2; Zhu, Baoli1
刊名MICROBIAL ECOLOGY
2013-08-01
DOI10.1007/s00248-013-0245-9
66期:2页:462-470
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Ecology ; Marine & Freshwater Biology ; Microbiology
研究领域[WOS]Environmental Sciences & Ecology ; Marine & Freshwater Biology ; Microbiology
关键词[WOS]BACTEROIDES-FRAGILIS ENTEROTOXIN ; INTESTINAL EPITHELIAL-CELLS ; HUMAN GUT MICROBIOTA ; NF-KAPPA-B ; ENTEROCOCCUS-FAECALIS ; WIDE ASSOCIATION ; EXPRESSION ; ACTIVATION ; SECRETION ; ETIOLOGY
英文摘要

The human gut microbiota is a complex system that is essential to the health of the host. Increasing evidence suggests that the gut microbiota may play an important role in the pathogenesis of colorectal cancer (CRC). In this study, we used pyrosequencing of the 16S rRNA gene V3 region to characterize the fecal microbiota of 19 patients with CRC and 20 healthy control subjects. The results revealed striking differences in fecal microbial population patterns between these two groups. Partial least-squares discriminant analysis showed that 17 phylotypes closely related to Bacteroides were enriched in the gut microbiota of CRC patients, whereas nine operational taxonomic units, represented by the butyrate-producing genera Faecalibacterium and Roseburia, were significantly less abundant. A positive correlation was observed between the abundance of Bacteroides species and CRC disease status (R = 0.462, P = 0.046 < 0.5). In addition, 16 genera were significantly more abundant in CRC samples than in controls, including potentially pathogenic Fusobacterium and Campylobacter species at genus level. The dysbiosis of fecal microbiota, characterized by the enrichment of potential pathogens and the decrease in butyrate-producing members, may therefore represent a specific microbial signature of CRC. A greater understanding of the dynamics of the fecal microbiota may assist in the development of novel fecal microbiome-related diagnostic tools for CRC.

语种英语
WOS记录号WOS:000321668900020
项目编号2009CB522605 ; 81021003 ; 2011-4022-06
资助机构National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China (NSFC) ; The Capital Health Research and Development of Special
引用统计
被引频次:122[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52285
专题北京大学第二临床医学院_消化科
作者单位1.Chinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol, Beijing 100101, Peoples R China
2.Chinese Acad Med Sci, Canc Inst & Hosp, Dept Abdominal Surg Oncol, Beijing 100021, Peoples R China
3.Zhejiang Univ, Affiliated Hosp 1, State Key Lab Diag & Treatment Infect Dis, Hangzhou 310003, Zhejiang, Peoples R China
4.Peking Univ, Peoples Hosp, Dept Gastroenterol, Beijing 100044, Peoples R China
5.Chinese Acad Sci, Beijing Inst Life Sci, Beijing 100101, Peoples R China
6.Chinese Natl Human Genome Ctr Shanghai, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714
Wu, Na,Yang, Xi,Zhang, Ruifen,et al. Dysbiosis Signature of Fecal Microbiota in Colorectal Cancer Patients[J]. MICROBIAL ECOLOGY,2013,66(2):462-470.
APA Wu, Na.,Yang, Xi.,Zhang, Ruifen.,Li, Jun.,Xiao, Xue.,...&Zhu, Baoli.(2013).Dysbiosis Signature of Fecal Microbiota in Colorectal Cancer Patients.MICROBIAL ECOLOGY,66(2),462-470.
MLA Wu, Na,et al."Dysbiosis Signature of Fecal Microbiota in Colorectal Cancer Patients".MICROBIAL ECOLOGY 66.2(2013):462-470.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Wu, Na]的文章
[Yang, Xi]的文章
[Zhang, Ruifen]的文章
百度学术
百度学术中相似的文章
[Wu, Na]的文章
[Yang, Xi]的文章
[Zhang, Ruifen]的文章
必应学术
必应学术中相似的文章
[Wu, Na]的文章
[Yang, Xi]的文章
[Zhang, Ruifen]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。