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学科主题临床医学
Plasma mitochondrial coupling factor 6 in patients with acute myocardial infarction
Ding, WH1; Chu, SY1; Jiang, HF1; Cai, DY1; Pang, YZ1; Tang, CS1; Yong, FQ1
关键词Coupling Factor 6 Acute Myocardial Infarction Peptide
刊名HYPERTENSION RESEARCH
2004-10-01
27期:10页:717-722
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Peripheral Vascular Disease
研究领域[WOS]Cardiovascular System & Cardiology
关键词[WOS]RATS
英文摘要

Previous studies have shown that mitochondrial coupling factor 6 (CF6) is an endogenous peptide that inhibits prostacyclin (PGI(2)) synthesis in vascular endothelial cells. In this study, we measured the plasma CF6 level of patients with acute myocardial infarction (AMI) to observe dynamic changes of CF6. All patients showed elevated plasma CF6 levels upon admission for treatment of AMI. Their CF6 levels peaked approximately 72 h after the onset of AMI and remained high for 7 days. At 7 days, their CF6 levels decreased to the level seen upon admission, but not to within a normal range. Hyperlipidemic patients had significantly greater CF6 levels at 24h after onset of AMI than patients with a normal lipid profile. On admission, the plasma CF6 level in patients with a cardiac function of Killip class greater than or equal to 11 was higher than that in patients with a Killip class I cardiac function. At 3 days after the onset of AMI, the plasma CF6 levels of patients with a creatinine kinase (CK) peak value greater than or equal to 1,500 units/I were significantly higher than those of patients with a CK peak value < 1,500 units/I (p = 0.05). At 7 days after the onset of AMI, the plasma CF6 levels of patients who received no reperfusion were significantly higher than those of patients who received a successful reperfusion. The plasma CF6 levels of AMI patients at admission, at 24 h, and at 3 days after onset of symptoms correlated positively with the cardiac function by Killip classification, respectively. At 24 h after onset of AMI, the plasma CF6 levels correlated positively with plasma total cholesterol levels and low-density lipoprotein levels. At 3 days, the plasma level of CF6 correlated positively with the plasma CK peak value and correlated negatively with left ventricular ejection fraction. These results suggest that the plasma CF6 level was elevated in patients with AMI.

语种英语
WOS记录号WOS:000227128800004
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被引频次:17[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52287
专题北京大学第一临床医学院_心血管内科
北京大学临床肿瘤学院_乳腺肿瘤内科
作者单位1.Peking Univ, Hosp 1, Inst Cardiovasc Res, Beijing 100034, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Physiol & Pathophysiol, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Ding, WH,Chu, SY,Jiang, HF,et al. Plasma mitochondrial coupling factor 6 in patients with acute myocardial infarction[J]. HYPERTENSION RESEARCH,2004,27(10):717-722.
APA Ding, WH.,Chu, SY.,Jiang, HF.,Cai, DY.,Pang, YZ.,...&Yong, FQ.(2004).Plasma mitochondrial coupling factor 6 in patients with acute myocardial infarction.HYPERTENSION RESEARCH,27(10),717-722.
MLA Ding, WH,et al."Plasma mitochondrial coupling factor 6 in patients with acute myocardial infarction".HYPERTENSION RESEARCH 27.10(2004):717-722.
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