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学科主题: 临床医学
题名:
Haploidentical stem cell transplantation in patients aged 50yr and older with leukemia: similar outcomes compared to younger adults
作者: Chen, Yao1; Wang, Yu1; Xu, Lan-Ping1; Liu, Kai-Yan1; Chen, Huan1; Chen, Yu-Hong1; Zhang, Xiao-Hui1; Wang, Feng-Rong1; Han, Wei1; Wang, Jing-Zhi1; Yan, Chen-Hua1; Zhang, Yuan-Yuan1; Sun, Yu-Qian1; Huang, Xiao-Jun1,2
关键词: age ; haploidentical ; HLA ; leukemia ; stem cell transplantation
刊名: CLINICAL TRANSPLANTATION
发表日期: 2015-06-01
DOI: 10.1111/ctr.12545
卷: 29, 期:6, 页:523-530
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Surgery ; Transplantation
研究领域[WOS]: Surgery ; Transplantation
关键词[WOS]: VERSUS-HOST-DISEASE ; BONE-MARROW-TRANSPLANTATION ; RISK-FACTORS ; CONDITIONING REGIMEN ; IMMUNE-SYSTEM ; T-CELLS ; BLOOD ; DEPLETION ; DONOR ; MALIGNANCIES
英文摘要:

AimWe aimed to analyze the complications and survival associated with myeloablative haploidentical SCT in patients aged 50yr and compare these results with a younger group population.

Design and methodsIn this case-control study, enrolled patients with leukemia were identified from 1262 patients between May 2002 and May 2013 at a single institution.

ResultsThirty-one patients were aged 50yr (the older group) and 165 patients were aged 18-49yr (the younger group). Of the older group, 20 of 31 (64.5%) had a hematopoietic cell transplantation comorbidity index (HCT-CI) of 0 or 2. Statistical analysis showed no significant differences in the incidences of grades II to IV acute GVHD, extensive chronic GVHD, and non-relapse mortality (NRM), or probability of relapse between the two groups. Furthermore, the 3-yr overall survival (OS) and leukemia-free survival (LFS) were not significantly different between the older and younger groups: 67.09.3% vs. 75.3 +/- 3.4% (p=0.406) and 60.5 +/- 9.6% vs. 72.5 +/- 3.5% (p=0.183), respectively.

ConclusionSelected older patients aged 50yr with low HCT-CI and good performance status could safely undergo haploidentical SCT.

语种: 英语
所属项目编号: Z121107002612035
项目资助者: Bejing Municipal Science &amp ; Technology Commission
WOS记录号: WOS:000356017700007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52288
Appears in Collections:北京大学第二临床医学院_血液科_期刊论文

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作者单位: 1.Peking Tsinghua Ctr Life Sci, Beijing, Peoples R China
2.Peking Univ, Inst Hematol, Peoples Hosp, Beijing 6006, Peoples R China

Recommended Citation:
Chen, Yao,Wang, Yu,Xu, Lan-Ping,et al. Haploidentical stem cell transplantation in patients aged 50yr and older with leukemia: similar outcomes compared to younger adults[J]. CLINICAL TRANSPLANTATION,2015,29(6):523-530.
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