| 学科主题 | 临床医学 |
| Haploidentical stem cell transplantation in patients aged 50yr and older with leukemia: similar outcomes compared to younger adults | |
| Chen, Yao1; Wang, Yu1; Xu, Lan-Ping1; Liu, Kai-Yan1; Chen, Huan1; Chen, Yu-Hong1; Zhang, Xiao-Hui1; Wang, Feng-Rong1; Han, Wei1; Wang, Jing-Zhi1; Yan, Chen-Hua1; Zhang, Yuan-Yuan1; Sun, Yu-Qian1; Huang, Xiao-Jun1,2 | |
| 关键词 | Age Haploidentical Hla Leukemia Stem Cell Transplantation |
| 刊名 | CLINICAL TRANSPLANTATION
 |
| 2015-06-01 | |
| DOI | 10.1111/ctr.12545 |
| 卷 | 29期:6页:523-530 |
| 收录类别 | SCI |
| 文章类型 | Article |
| WOS标题词 | Science & Technology |
| 类目[WOS] | Surgery ; Transplantation |
| 资助者 | Bejing Municipal Science & ; Technology Commission ; Bejing Municipal Science & ; Technology Commission |
| 研究领域[WOS] | Surgery ; Transplantation |
| 关键词[WOS] | VERSUS-HOST-DISEASE ; BONE-MARROW-TRANSPLANTATION ; RISK-FACTORS ; CONDITIONING REGIMEN ; IMMUNE-SYSTEM ; T-CELLS ; BLOOD ; DEPLETION ; DONOR ; MALIGNANCIES |
| 英文摘要 | AimWe aimed to analyze the complications and survival associated with myeloablative haploidentical SCT in patients aged 50yr and compare these results with a younger group population. Design and methodsIn this case-control study, enrolled patients with leukemia were identified from 1262 patients between May 2002 and May 2013 at a single institution. ResultsThirty-one patients were aged 50yr (the older group) and 165 patients were aged 18-49yr (the younger group). Of the older group, 20 of 31 (64.5%) had a hematopoietic cell transplantation comorbidity index (HCT-CI) of 0 or 2. Statistical analysis showed no significant differences in the incidences of grades II to IV acute GVHD, extensive chronic GVHD, and non-relapse mortality (NRM), or probability of relapse between the two groups. Furthermore, the 3-yr overall survival (OS) and leukemia-free survival (LFS) were not significantly different between the older and younger groups: 67.09.3% vs. 75.3 +/- 3.4% (p=0.406) and 60.5 +/- 9.6% vs. 72.5 +/- 3.5% (p=0.183), respectively. ConclusionSelected older patients aged 50yr with low HCT-CI and good performance status could safely undergo haploidentical SCT. |
| 语种 | 英语 |
| 所属项目编号 | Z121107002612035 |
| 资助者 | Bejing Municipal Science & ; Technology Commission ; Bejing Municipal Science & ; Technology Commission |
| WOS记录号 | WOS:000356017700007 |
| Citation statistics | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.bjmu.edu.cn/handle/400002259/52288 |
| Collection | 北京大学第二临床医学院_血液科 |
| 作者单位 | 1.Peking Tsinghua Ctr Life Sci, Beijing, Peoples R China 2.Peking Univ, Inst Hematol, Peoples Hosp, Beijing 6006, Peoples R China |
| Recommended Citation GB/T 7714 | Chen, Yao,Wang, Yu,Xu, Lan-Ping,et al. Haploidentical stem cell transplantation in patients aged 50yr and older with leukemia: similar outcomes compared to younger adults[J]. CLINICAL TRANSPLANTATION,2015,29(6):523-530. |
| APA | Chen, Yao.,Wang, Yu.,Xu, Lan-Ping.,Liu, Kai-Yan.,Chen, Huan.,...&Huang, Xiao-Jun.(2015).Haploidentical stem cell transplantation in patients aged 50yr and older with leukemia: similar outcomes compared to younger adults.CLINICAL TRANSPLANTATION,29(6),523-530. |
| MLA | Chen, Yao,et al."Haploidentical stem cell transplantation in patients aged 50yr and older with leukemia: similar outcomes compared to younger adults".CLINICAL TRANSPLANTATION 29.6(2015):523-530. |
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