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Imaging Functional and Structural Brain Connectomics in Attention-Deficit/Hyperactivity Disorder
Cao, Miao1,2,3; Shu, Ni1,2,3; Cao, Qingjiu4,5,6; Wang, Yufeng4,5,6; He, Yong1,2,3
关键词Adhd Connectome Graph Theory Small-world Functional Connectivity Structural Connectivity
刊名MOLECULAR NEUROBIOLOGY
2014-12-01
DOI10.1007/s12035-014-8685-x
50期:3页:1111-1123
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Neurosciences
资助者973 Program ; National Science Fund for Distinguished Young Scholars ; Natural Science Foundation of China ; BNU-MRI Demonstration Unit ; Beijing Funding for Training Talents ; 973 Program ; National Science Fund for Distinguished Young Scholars ; Natural Science Foundation of China ; BNU-MRI Demonstration Unit ; Beijing Funding for Training Talents
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]DEFICIT HYPERACTIVITY DISORDER ; GRAPH-THEORETICAL ANALYSIS ; RICH-CLUB ORGANIZATION ; SMALL-WORLD NETWORKS ; CONNECTIVITY PATTERNS ; CORTICAL THICKNESS ; ANATOMICAL NETWORKS ; ALZHEIMERS-DISEASE ; DIFFUSION MRI ; HEAD MOTION
英文摘要

Attention-deficit/hyperactivity disorder (ADHD) is one of the most common neurodevelopment disorders in childhood. Clinically, the core symptoms of this disorder include inattention, hyperactivity, and impulsivity. Previous studies have documented that these behavior deficits in ADHD children are associated with not only regional brain abnormalities but also changes in functional and structural connectivity among regions. In the past several years, our understanding of how ADHD affects the brain′s connectivity has been greatly advanced by mapping topological alterations of large-scale brain networks (i.e., connectomes) using non-invasive neurophysiological and neuroimaging techniques (e. g., electroencephalograph, functional MRI, and diffusion MRI) in combination with graph theoretical approaches. In this review, we summarize the recent progresses of functional and structural brain connectomics in ADHD, focusing on graphic analysis of large-scale brain systems. Convergent evidence suggests that children with ADHD had abnormal small-world properties in both functional and structural brain networks characterized by higher local clustering and lower global integrity, suggesting a disorder-related shift of network topology toward regular configurations. Moreover, ADHD children showed the redistribution of regional nodes and connectivity involving the default-mode, attention, and sensorimotor systems. Importantly, these ADHD-associated alterations significantly correlated with behavior disturbances (e. g., inattention and hyperactivity/impulsivity symptoms) and exhibited differential patterns between clinical subtypes. Together, these connectome-based studies highlight brain network dysfunction in ADHD, thus opening up a new window into our understanding of the pathophysiological mechanisms of this disorder. These works might also have important implications on the development of imaging-based bio-markers for clinical diagnosis and treatment evaluation in ADHD.

语种英语
所属项目编号2013CB837300 ; 2014CB846102 ; 81225012 ; 81030028 ; 31221003 ; CERS-1-52
资助者973 Program ; National Science Fund for Distinguished Young Scholars ; Natural Science Foundation of China ; BNU-MRI Demonstration Unit ; Beijing Funding for Training Talents ; 973 Program ; National Science Fund for Distinguished Young Scholars ; Natural Science Foundation of China ; BNU-MRI Demonstration Unit ; Beijing Funding for Training Talents
WOS记录号WOS:000344865700030
引用统计
被引频次:27[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52289
专题北京大学精神卫生研究所
作者单位1.Minist Hlth, Key Lab Mental Hlth, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 6, Beijing 100191, Peoples R China
3.Peking Univ, Inst Mental Hlth, Beijing 100191, Peoples R China
4.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China
5.Beijing Normal Univ, IDG McGovern Inst Brain Res, Beijing 100875, Peoples R China
6.Beijing Normal Univ, Ctr Collaborat & Innovat Brain & Learning Sci, Beijing 100875, Peoples R China
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GB/T 7714
Cao, Miao,Shu, Ni,Cao, Qingjiu,et al. Imaging Functional and Structural Brain Connectomics in Attention-Deficit/Hyperactivity Disorder[J]. MOLECULAR NEUROBIOLOGY,2014,50(3):1111-1123.
APA Cao, Miao,Shu, Ni,Cao, Qingjiu,Wang, Yufeng,&He, Yong.(2014).Imaging Functional and Structural Brain Connectomics in Attention-Deficit/Hyperactivity Disorder.MOLECULAR NEUROBIOLOGY,50(3),1111-1123.
MLA Cao, Miao,et al."Imaging Functional and Structural Brain Connectomics in Attention-Deficit/Hyperactivity Disorder".MOLECULAR NEUROBIOLOGY 50.3(2014):1111-1123.
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