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学科主题: 临床医学
题名:
The association of CYP2C9 gene polymorphisms with colorectal carcinoma in Han Chinese
作者: Liao, Ling-Hong1; Zhang, Hao1; Lai, Man-Po1; Lau, Kwok-Wai1; Lai, Albert Kai-Cheong1; Zhang, Jin-Hui1; Wang, Qi1; Wei, Wei1; Chai, Jian-Hua1; Lung, Maria Li1; Tai, Susan S. W.1; Wu, Madeline1
关键词: CYP2C9 ; SNP ; Chinese ; colorectal carcinoma
刊名: CLINICA CHIMICA ACTA
发表日期: 2007-05-01
DOI: 10.1016/j.cca.2007.02.033
卷: 380, 期:1-2, 页:191-196
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medical Laboratory Technology
研究领域[WOS]: Medical Laboratory Technology
关键词[WOS]: NONSTEROIDAL ANTIINFLAMMATORY DRUGS ; LUNG-CANCER RISK ; ALLELIC VARIANTS ; DIETARY CARCINOGENS ; GENOTYPES ; UGT1A6 ; CYTOCHROME-P450 ; OXIDOREDUCTASE ; CAUCASIANS ; PREVENTION
英文摘要:

Background: Cytochrome P450 (CYP) 2C9 is an important enzyme involved in xenobiotics metabolism. This study investigated the association of CYP2C9 gene coding region polymorphisms with colorectal cancer (CRC) in Chinese Han population.

Methods: Four hundred and eighty-three healthy controls and 286 sporadic CRC patients participated in this study. Direct sequencing was used to identify the sequence polymorphisms.

Results: We detected the significant association of 2 coding region SNPs, rs 10579 10 and rs 1057911, of CYP2C9 with the risk of developing sporadic CRC for Han Chinese. These 2 SNPs showed a strong linkage disequilibrium (LD) (r(2) =0.97, D ′=0.985). Significantly different minor allele frequencies were found for SNPs rs1057910 and rs1057911 between the cases (7% and 7.2%, respectively) and controls (3% and 2.9%, respectively) with adjusted P=0.0004 and 0.0002, respectively. Individuals heterozygous for rs1057910A/C or rs1057911A/T showed 2.589-fold (95% CI: 1.549-4.330) or 2.770-fold (95% CI 1.653-4.643) increased risk of developing sporadic CRC. We did not detect any homozygote minor allele carrier for either rs1057910 or rs1057911 in our study population. The CRC association appeared to be more evident for individuals over age 50 y, for men, and for rectum cancer site.

Conclusion: There is an association of CYP2C9 coding region polymorphisms with the risk of developing CRC in Han Chinese after genotyping cases and controls recruited from different locations in China. (C) 2007 Elsevier B.V. All rights reserved.

语种: 英语
WOS记录号: WOS:000246645500029
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52290
Appears in Collections:北京大学深圳医院_期刊论文

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作者单位: 1.Mochtar Riady Inst Nantechnol, Lippo Karawaci Tangerang 15811, Indonesia
2.Tuen Mun Hosp, Dept Surg, Hong Kong, Hong Kong, Peoples R China
3.Fudan Univ, Inst Genet, Shanghai, Peoples R China
4.Hong Kong Univ Sci & Technol, Dept Biol, Kowloon, Hong Kong, Peoples R China
5.Hong Kong Univ Sci & Technol, Ctr Canc Res, Kowloon, Hong Kong, Peoples R China
6.Hong Kong Univ Sci & Technol, Appl Genom Ctr, Hong Kong, Hong Kong, Peoples R China
7.Dalian Med Univ, Hosp Affiliated 2, Dept Resp, Dalian, Peoples R China
8.Peking Univ, Shenzhen Hosp, Mammary Gland Surg Dept, Shenzhen, Peoples R China

Recommended Citation:
Liao, Ling-Hong,Zhang, Hao,Lai, Man-Po,et al. The association of CYP2C9 gene polymorphisms with colorectal carcinoma in Han Chinese[J]. CLINICA CHIMICA ACTA,2007,380(1-2):191-196.
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