北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学临床肿瘤学院  > 超声科  > 期刊论文
学科主题: 临床医学
题名:
Radiofrequency ablation of hepatocellular carcinoma: Long-term outcome and prognostic factors
作者: Yan, Kun1; Chen, Min Hua1; Yang, Wei1; Wang, Yan Bin1; Gao, Wen1; Hao, Chun Yi1; Xing, Bao Cai2; Huang, Xin Fu2
关键词: hepatocellular carcinoma ; radiofrequency ablation ; long-term outcome ; ultrasonography
刊名: EUROPEAN JOURNAL OF RADIOLOGY
发表日期: 2008-08-01
DOI: 10.1016/j.ejrad.2007.07.007
卷: 67, 期:2, 页:336-347
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]: Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]: TRANSCATHETER ARTERIAL CHEMOEMBOLIZATION ; FOCAL LIVER-TUMORS ; THERMAL ABLATION ; HEPATIC-TUMORS ; THERAPEUTIC-EFFICACY ; UNITED-STATES ; CIRRHOSIS ; RESECTION ; SURVIVAL ; MALIGNANCIES
英文摘要:

Purpose: To investigate the efficacy of radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC), and the prognostic factors for post-RFA survival rate.

Methods: From 1999 to 2006, 266 patients with 392 HCCs underwent ultrasound guided RFA treatment. They were 216 males and 50 females, average age 59.4 +/- 15.4 years (24-87 years). The HCC were 1.2-6.7 cm in diameters (average 3.9 + 1.3 cm). There were 158 patients with single tumor, and the rest had multiple (2-5) tumors. Univariate and multivariate analysis with 19 potential variables were examined to identify prognostic factors for post-RFA survival rate.

Results: The overall post-RFA survival rates at 1st, 3rd, and 5th year were 82.9%, 57.9% and 42.9%, respectively. In the 60 patients with stage I HCC (AJCC staging), the 1-, 3-, 5-year survival rate were 94.8%, 76.4% and 71.6%, significantly higher than the 148 patients with stage II-IV tumors (81.8%, 57.6% and 41.2%, P=0.006). For the 58 patients with post-surgery recurrent HCC, the survival rates were 73.2%, 41.9% and 38.2% at the 1st, 3rd, and 5th year, which were significantly lower than those of stage I HCC (P=0.005). Nine potential factors were found with significant effects on survival rate, and they were number of tumors, location of tumors, pre-RFA liver function enzymes, Child-Pugh classification, AJCC staging, primary or recurrent HCC, tumor pathological grading, using mathematical protocol in RFA procedure and tumor necrosis 1 month after RFA. After multivariate analysis, three factors were identified as independent prognostic factors for survival rate, and they were Child-Pugh classification, AJCC staging and using mathematical protocol.

Conclusion: Identifying prognostic factors provides important information for HCC patient management before, during and after RFA. This long-term follow-up study on a large group of HCC patients confirmed that RFA could not only achieve favorable outcome on stage I HCC, but also be an effective therapy for stage II-IV or recurrent HCC. (C) 2007 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000258369800019
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52292
Appears in Collections:北京大学临床肿瘤学院_超声科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst, Dept Ultrasound, Beijing 100036, Peoples R China
2.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst, Dept Surg, Beijing 100036, Peoples R China

Recommended Citation:
Yan, Kun,Chen, Min Hua,Yang, Wei,et al. Radiofrequency ablation of hepatocellular carcinoma: Long-term outcome and prognostic factors[J]. EUROPEAN JOURNAL OF RADIOLOGY,2008,67(2):336-347.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Yan, Kun]'s Articles
[Chen, Min Hua]'s Articles
[Yang, Wei]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Yan, Kun]‘s Articles
[Chen, Min Hua]‘s Articles
[Yang, Wei]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace