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学科主题: 临床医学
题名:
Radiofrequency ablation of hepatocellular carcinoma: Long-term outcome and prognostic factors
作者: Yan, Kun1; Chen, Min Hua1; Yang, Wei1; Wang, Yan Bin1; Gao, Wen1; Hao, Chun Yi1; Xing, Bao Cai2; Huang, Xin Fu2
关键词: hepatocellular carcinoma ; radiofrequency ablation ; long-term outcome ; ultrasonography
刊名: EUROPEAN JOURNAL OF RADIOLOGY
发表日期: 2008-08-01
DOI: 10.1016/j.ejrad.2007.07.007
卷: 67, 期:2, 页:336-347
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]: Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]: TRANSCATHETER ARTERIAL CHEMOEMBOLIZATION ; FOCAL LIVER-TUMORS ; THERMAL ABLATION ; HEPATIC-TUMORS ; THERAPEUTIC-EFFICACY ; UNITED-STATES ; CIRRHOSIS ; RESECTION ; SURVIVAL ; MALIGNANCIES
英文摘要:

Purpose: To investigate the efficacy of radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC), and the prognostic factors for post-RFA survival rate.

Methods: From 1999 to 2006, 266 patients with 392 HCCs underwent ultrasound guided RFA treatment. They were 216 males and 50 females, average age 59.4 +/- 15.4 years (24-87 years). The HCC were 1.2-6.7 cm in diameters (average 3.9 + 1.3 cm). There were 158 patients with single tumor, and the rest had multiple (2-5) tumors. Univariate and multivariate analysis with 19 potential variables were examined to identify prognostic factors for post-RFA survival rate.

Results: The overall post-RFA survival rates at 1st, 3rd, and 5th year were 82.9%, 57.9% and 42.9%, respectively. In the 60 patients with stage I HCC (AJCC staging), the 1-, 3-, 5-year survival rate were 94.8%, 76.4% and 71.6%, significantly higher than the 148 patients with stage II-IV tumors (81.8%, 57.6% and 41.2%, P=0.006). For the 58 patients with post-surgery recurrent HCC, the survival rates were 73.2%, 41.9% and 38.2% at the 1st, 3rd, and 5th year, which were significantly lower than those of stage I HCC (P=0.005). Nine potential factors were found with significant effects on survival rate, and they were number of tumors, location of tumors, pre-RFA liver function enzymes, Child-Pugh classification, AJCC staging, primary or recurrent HCC, tumor pathological grading, using mathematical protocol in RFA procedure and tumor necrosis 1 month after RFA. After multivariate analysis, three factors were identified as independent prognostic factors for survival rate, and they were Child-Pugh classification, AJCC staging and using mathematical protocol.

Conclusion: Identifying prognostic factors provides important information for HCC patient management before, during and after RFA. This long-term follow-up study on a large group of HCC patients confirmed that RFA could not only achieve favorable outcome on stage I HCC, but also be an effective therapy for stage II-IV or recurrent HCC. (C) 2007 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000258369800019
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52292
Appears in Collections:北京大学临床肿瘤学院_超声科_期刊论文

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作者单位: 1.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst, Dept Ultrasound, Beijing 100036, Peoples R China
2.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst, Dept Surg, Beijing 100036, Peoples R China

Recommended Citation:
Yan, Kun,Chen, Min Hua,Yang, Wei,et al. Radiofrequency ablation of hepatocellular carcinoma: Long-term outcome and prognostic factors[J]. EUROPEAN JOURNAL OF RADIOLOGY,2008,67(2):336-347.
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