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学科主题: 临床医学
题名:
SOLUBLE CD146 IN CEREBROSPINAL FLUID OF ACTIVE MULTIPLE SCLEROSIS
作者: Duan, H.1,2; Luo, Y.1; Hao, H.3; Feng, L.4; Zhang, Y.1; Lu, D.1; Xing, S.1,2; Feng, J.1; Yang, D.1; Song, L.1; Yan, X.1
关键词: sCD146 ; multiple sclerosis ; cerebrospinal fluid ; inflammatory factors
刊名: NEUROSCIENCE
发表日期: 2013-04-03
DOI: 10.1016/j.neuroscience.2013.01.020
卷: 235, 页:16-26
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: SYSTEMIC-LUPUS-ERYTHEMATOSUS ; INFLAMMATORY-BOWEL-DISEASE ; ADHESION MOLECULES SVCAM-1 ; CENTRAL-NERVOUS-SYSTEM ; TNF-ALPHA ; TRANSENDOTHELIAL MIGRATION ; ENDOTHELIAL MICROPARTICLES ; INCREASED EXPRESSION ; MRI ACTIVITY ; SE-SELECTIN
英文摘要:

The soluble form of CD146 has been reported to be present in various inflammatory diseases and displays pro-inflammatory properties. However, little is known about sCD146 in multiple sclerosis (MS). Here we show that sCD146 is significantly elevated in the cerebrospinal fluid of patients with active MS compared with that of inactive MS or patients with non-demyelinating diseases. Moreover, abnormally increased sCD146 in the CSF of active MS patients correlated with albumin quotient, MBP antibody and MOO antibody from both CSF and sera. Importantly, the level of CSF sCD146 is correlated with levels of inflammatory factors, such as TNF alpha, IFN gamma, IL-2, and IL-17A in the CSF. We also found that CSF sCD146 might originate from membrane-bound CD146 on inflamed blood-brain barrier (BBB) endothelial cells. In addition, sCD146 promotes leukocyte transmigration in vitro, at least in part by stimulating the expression of ICAM-1 and VCAM-1 on endothelial cells. Our findings suggest that CSF levels of sCD146 may provide a potential marker for monitoring disease activity in MS patients. (C) 2013 IBRO. Published by Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 2009CB521704 ; 2011CB915502 ; 81272409 ; 91029732 ; KSCX2-YW-M15
项目资助者: National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China ; Knowledge Innovation Program of the Chinese Academy of Sciences
WOS记录号: WOS:000316973800003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52294
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Beijing 100034, Peoples R China
2.Chinese Acad Sci, Key Lab Prot & Peptide Pharmaceut, CAS Univ Tokyo Joint Lab Struct Virol & Immunol, Inst Biophys, Beijing 100101, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Capital Univ Med Sci, Beijing Anzhen Hosp, Beijing 100029, Peoples R China

Recommended Citation:
Duan, H.,Luo, Y.,Hao, H.,et al. SOLUBLE CD146 IN CEREBROSPINAL FLUID OF ACTIVE MULTIPLE SCLEROSIS[J]. NEUROSCIENCE,2013,235:16-26.
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