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学科主题: 临床医学
题名:
Discovery of distinct protein profiles for polycystic ovary syndrome with and without insulin resistance by surface-enhanced laser adsorption/ionization time of flight mass spectrometry
作者: Zhao, Shuyun1; Qiao, Jie1; Li, Meizhi1; Zhang, Xiaowei1; Yu, Jiekai1; Li, Rong1
关键词: polycystic ovary syndrome ; insulin resistance ; protein profile ; surface-enhanced laser adsorption/ionization time of flight mass spectrometry ; weak cation exchange protein chip
刊名: FERTILITY AND STERILITY
发表日期: 2007-07-01
DOI: 10.1016/j.fertnstert.2006.11.207
卷: 88, 期:1, 页:145-151
收录类别: ISTP ; SCI
文章类型: Proceedings Paper
WOS标题词: Science & Technology
类目[WOS]: Obstetrics & Gynecology ; Reproductive Biology
研究领域[WOS]: Obstetrics & Gynecology ; Reproductive Biology
关键词[WOS]: PROTEOMICS ; CANCER ; DISEASE ; SERUM ; IDENTIFICATION ; POPULATION
英文摘要:

Objective: To screen the serum protein expression profiles in patients having polycystic ovary syndrome (PCOS) with or without insulin resistance (IR) and search for discriminatory proteins.

Design: Cross-sectional study.

Setting: Reproductive Center of Peking University Third Hospital.

Patient(s): Thirty patients with PCOS with IR, 30 patients with PCOS without IR and 30 controls individuals.

Intervention(s): Fasting serum samples.

Main Outcome Measure(s): Serum protein peak spectrum.

Result(s): There were 27 differential protein peaks between patients with PCOS and IR and controls, 17 between patients with PCOS without IR and controls, and 19 between patients with PCOS and IR and patients without IR. Marker proteins from differentially expressed proteins were screened out with use of a support vector machine and were used to establish three diagnostic models for PCOS IR, PCOS non-IR, and IR, respectively.

Conclusion(s): There were statistically significantly different serum proteomic patterns in different types of PCOS. With use of ProteinChip combined with the support vector machine, computer diagnostic models for PCOS with and without IR were set up quickly and efficiently. These discriminatory proteins may help us understand the proteomic changes in serum and find out potential biomarkers of PCOS and IR.

语种: 英语
WOS记录号: WOS:000248054100022
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52297
Appears in Collections:北京大学第三临床医学院_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Dept Obstet & Gynecol, Beijing 100083, Peoples R China
2.Affiliated Hosp, Guiyang Med Coll, Dept Obstet & Gynecol, Guiyang, Peoples R China
3.Zhejiang Univ, Coll Med, Inst Canc, Affiliated Hosp 2, Hangzhou, Peoples R China

Recommended Citation:
Zhao, Shuyun,Qiao, Jie,Li, Meizhi,et al. Discovery of distinct protein profiles for polycystic ovary syndrome with and without insulin resistance by surface-enhanced laser adsorption/ionization time of flight mass spectrometry[J]. FERTILITY AND STERILITY,2007,88(1):145-151.
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