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Discovery of distinct protein profiles for polycystic ovary syndrome with and without insulin resistance by surface-enhanced laser adsorption/ionization time of flight mass spectrometry
Zhao, Shuyun1; Qiao, Jie1; Li, Meizhi1; Zhang, Xiaowei1; Yu, Jiekai1; Li, Rong1
关键词Polycystic Ovary Syndrome Insulin Resistance Protein Profile Surface-enhanced Laser Adsorption/ionization Time Of Flight Mass Spectrometry Weak Cation Exchange Protein Chip
刊名FERTILITY AND STERILITY
2007-07-01
DOI10.1016/j.fertnstert.2006.11.207
88期:1页:145-151
收录类别ISTP ; SCI
文章类型Proceedings Paper
WOS标题词Science & Technology
类目[WOS]Obstetrics & Gynecology ; Reproductive Biology
研究领域[WOS]Obstetrics & Gynecology ; Reproductive Biology
关键词[WOS]PROTEOMICS ; CANCER ; DISEASE ; SERUM ; IDENTIFICATION ; POPULATION
英文摘要

Objective: To screen the serum protein expression profiles in patients having polycystic ovary syndrome (PCOS) with or without insulin resistance (IR) and search for discriminatory proteins.

Design: Cross-sectional study.

Setting: Reproductive Center of Peking University Third Hospital.

Patient(s): Thirty patients with PCOS with IR, 30 patients with PCOS without IR and 30 controls individuals.

Intervention(s): Fasting serum samples.

Main Outcome Measure(s): Serum protein peak spectrum.

Result(s): There were 27 differential protein peaks between patients with PCOS and IR and controls, 17 between patients with PCOS without IR and controls, and 19 between patients with PCOS and IR and patients without IR. Marker proteins from differentially expressed proteins were screened out with use of a support vector machine and were used to establish three diagnostic models for PCOS IR, PCOS non-IR, and IR, respectively.

Conclusion(s): There were statistically significantly different serum proteomic patterns in different types of PCOS. With use of ProteinChip combined with the support vector machine, computer diagnostic models for PCOS with and without IR were set up quickly and efficiently. These discriminatory proteins may help us understand the proteomic changes in serum and find out potential biomarkers of PCOS and IR.

语种英语
WOS记录号WOS:000248054100022
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52297
专题北京大学第三临床医学院
北京大学第三临床医学院_生殖医学中心
作者单位1.Peking Univ, Hosp 3, Dept Obstet & Gynecol, Beijing 100083, Peoples R China
2.Affiliated Hosp, Guiyang Med Coll, Dept Obstet & Gynecol, Guiyang, Peoples R China
3.Zhejiang Univ, Coll Med, Inst Canc, Affiliated Hosp 2, Hangzhou, Peoples R China
推荐引用方式
GB/T 7714
Zhao, Shuyun,Qiao, Jie,Li, Meizhi,et al. Discovery of distinct protein profiles for polycystic ovary syndrome with and without insulin resistance by surface-enhanced laser adsorption/ionization time of flight mass spectrometry[J]. FERTILITY AND STERILITY,2007,88(1):145-151.
APA Zhao, Shuyun,Qiao, Jie,Li, Meizhi,Zhang, Xiaowei,Yu, Jiekai,&Li, Rong.(2007).Discovery of distinct protein profiles for polycystic ovary syndrome with and without insulin resistance by surface-enhanced laser adsorption/ionization time of flight mass spectrometry.FERTILITY AND STERILITY,88(1),145-151.
MLA Zhao, Shuyun,et al."Discovery of distinct protein profiles for polycystic ovary syndrome with and without insulin resistance by surface-enhanced laser adsorption/ionization time of flight mass spectrometry".FERTILITY AND STERILITY 88.1(2007):145-151.
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