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Prognosis after unmanipulated HLA-haploidentical blood and marrow transplantation is correlated to the numbers of KIR ligands in recipients
Zhao, Xiang-yu; Huang, Xiao-jun; Liu, Kai-yan; Xu, Lan-ping; Liu, Dai-hong
关键词Haploidentical Hematopoietic Stem Cell Transplantation Killer Immunoglobulin-like Receptors
刊名EUROPEAN JOURNAL OF HAEMATOLOGY
2007-04-01
DOI10.1111/j.1600-0609.2007.00822.x
78期:4页:338-346
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Hematology
研究领域[WOS]Hematology
关键词[WOS]STEM-CELL TRANSPLANTATION ; IMMUNOGLOBULIN-LIKE RECEPTORS ; UNRELATED DONORS ; HEMATOPOIETIC TRANSPLANTS ; PSORIATIC-ARTHRITIS ; T-CELLS ; INCOMPATIBILITY ; LEUKEMIA ; GENES ; ALLOREACTIVITY
英文摘要

Objectives: The goal of this study was to explore the role of NK cell alloreaction in predicting prognosis under unmanipulated HLA-haploidentical blood and marrow transplantation and examine whether the presence of any individual donor-activating KIR gene had an influence on the clinical outcome. Methods: We studied the HLA and KIR genotype of 64 donor-recipient pairs, who underwent transplantation. Results: In contrast to Perugia′s KIR ligand-ligand mismatch model or Handgretinger′s KIR receptor-ligand mismatch model or Bignon′s KIR gene-gene mismatch model between donor-recipient pairs, we found that the cumulative incidence of 3-yr disease-free survival (DFS), overall survival (OS), and transplantation-related mortality (TRM) were best predicted by the number of KIR ligands carried by patients (HR 0.355, 95% CI 0.186-0.678, P = 0.002 for DFS; HR 0.445, 95% CI 0.233-0.848, P = 0.014 for OS; HR 0.450, 95% CI 0.219-0.926, P = 0.030 for TRM). Moreover, an analysis of KIR ligand numbers was found to be correlative in patients with lymphoid malignancy. The KIR ligand-ligand mismatch model is a good predictor of acute graft vs. host disease (aGVHD; HR 3.812, 95% CI 1.667-8.720, P = 0.002). Meanwhile, the presence of donor-activating KIR2DS3 also contributed significantly to acute (HR 2.967, 95% CI 1.265-6.958, P = 0.012) and chronic GVHD (HR 2.541, 95% CI 1.127-5.730, P = 0.025). Conclusions: These data indicate that prognosis after transplantation is associated with the numbers of KIR ligands in recipients and T-cell alloreaction may play a predominant role in this model.

语种英语
WOS记录号WOS:000244718800009
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被引频次:26[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52298
专题北京大学第二临床医学院_血液科
作者单位Peking Univ, Peoples Hosp, Inst Hematol, Beijing 100044, Peoples R China
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GB/T 7714
Zhao, Xiang-yu,Huang, Xiao-jun,Liu, Kai-yan,et al. Prognosis after unmanipulated HLA-haploidentical blood and marrow transplantation is correlated to the numbers of KIR ligands in recipients[J]. EUROPEAN JOURNAL OF HAEMATOLOGY,2007,78(4):338-346.
APA Zhao, Xiang-yu,Huang, Xiao-jun,Liu, Kai-yan,Xu, Lan-ping,&Liu, Dai-hong.(2007).Prognosis after unmanipulated HLA-haploidentical blood and marrow transplantation is correlated to the numbers of KIR ligands in recipients.EUROPEAN JOURNAL OF HAEMATOLOGY,78(4),338-346.
MLA Zhao, Xiang-yu,et al."Prognosis after unmanipulated HLA-haploidentical blood and marrow transplantation is correlated to the numbers of KIR ligands in recipients".EUROPEAN JOURNAL OF HAEMATOLOGY 78.4(2007):338-346.
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