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学科主题: 临床医学
题名:
Prognosis after unmanipulated HLA-haploidentical blood and marrow transplantation is correlated to the numbers of KIR ligands in recipients
作者: Zhao, Xiang-yu; Huang, Xiao-jun; Liu, Kai-yan; Xu, Lan-ping; Liu, Dai-hong
关键词: haploidentical ; hematopoietic stem cell transplantation ; killer immunoglobulin-like receptors
刊名: EUROPEAN JOURNAL OF HAEMATOLOGY
发表日期: 2007-04-01
DOI: 10.1111/j.1600-0609.2007.00822.x
卷: 78, 期:4, 页:338-346
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Hematology
研究领域[WOS]: Hematology
关键词[WOS]: STEM-CELL TRANSPLANTATION ; IMMUNOGLOBULIN-LIKE RECEPTORS ; UNRELATED DONORS ; HEMATOPOIETIC TRANSPLANTS ; PSORIATIC-ARTHRITIS ; T-CELLS ; INCOMPATIBILITY ; LEUKEMIA ; GENES ; ALLOREACTIVITY
英文摘要:

Objectives: The goal of this study was to explore the role of NK cell alloreaction in predicting prognosis under unmanipulated HLA-haploidentical blood and marrow transplantation and examine whether the presence of any individual donor-activating KIR gene had an influence on the clinical outcome. Methods: We studied the HLA and KIR genotype of 64 donor-recipient pairs, who underwent transplantation. Results: In contrast to Perugia′s KIR ligand-ligand mismatch model or Handgretinger′s KIR receptor-ligand mismatch model or Bignon′s KIR gene-gene mismatch model between donor-recipient pairs, we found that the cumulative incidence of 3-yr disease-free survival (DFS), overall survival (OS), and transplantation-related mortality (TRM) were best predicted by the number of KIR ligands carried by patients (HR 0.355, 95% CI 0.186-0.678, P = 0.002 for DFS; HR 0.445, 95% CI 0.233-0.848, P = 0.014 for OS; HR 0.450, 95% CI 0.219-0.926, P = 0.030 for TRM). Moreover, an analysis of KIR ligand numbers was found to be correlative in patients with lymphoid malignancy. The KIR ligand-ligand mismatch model is a good predictor of acute graft vs. host disease (aGVHD; HR 3.812, 95% CI 1.667-8.720, P = 0.002). Meanwhile, the presence of donor-activating KIR2DS3 also contributed significantly to acute (HR 2.967, 95% CI 1.265-6.958, P = 0.012) and chronic GVHD (HR 2.541, 95% CI 1.127-5.730, P = 0.025). Conclusions: These data indicate that prognosis after transplantation is associated with the numbers of KIR ligands in recipients and T-cell alloreaction may play a predominant role in this model.

语种: 英语
WOS记录号: WOS:000244718800009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52298
Appears in Collections:北京大学第二临床医学院_血液科_期刊论文

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作者单位: Peking Univ, Peoples Hosp, Inst Hematol, Beijing 100044, Peoples R China

Recommended Citation:
Zhao, Xiang-yu,Huang, Xiao-jun,Liu, Kai-yan,et al. Prognosis after unmanipulated HLA-haploidentical blood and marrow transplantation is correlated to the numbers of KIR ligands in recipients[J]. EUROPEAN JOURNAL OF HAEMATOLOGY,2007,78(4):338-346.
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