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学科主题: 药物依赖
题名:
Tramadol induces conditioned place preference in rats: Interactions with morphine and buprenorphine
作者: Zhang, Min1; Jing, Li2; Liu, Qing1; Wen, Rui-Ting1; Li, Jun-Xu3; Li, Yu-Ling1; Gong, Qi1; Liang, Jian-Hui1
关键词: Tramadol ; Morphine ; Buprenorphine ; Drug interaction ; Conditioned place preference
刊名: NEUROSCIENCE LETTERS
发表日期: 2012-06-27
DOI: 10.1016/j.neulet.2012.05.037
卷: 520, 期:1, 页:87-91
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: MU-OPIOID-RECEPTOR ; POSTMARKETING SURVEILLANCE ; DISCRIMINATIVE STIMULUS ; ABUSE LIABILITY ; DRUG-DEPENDENCE ; CONSISTENT ; HUMANS ; REWARD ; MICE ; SENSITIZATION
英文摘要:

Surveys and drug surveillance have demonstrated that the abuse liability of tramadol is considerably low in the general population but appears to be higher in opiate addicts, and this difference could attribute to the poly-drug abuse of opioid addicts, although this hypothesis has not been tested in the laboratory. The present study examined the interactions between tramadol and a full mu opioid receptor agonist morphine or a partial mu opioid receptor agonist buprenorphine in a conditioned place preference (CPP) paradigm in rats. Rats were conditioned with tramadol (2-54 mg/kg, i.p.), morphine (0.125-8 mg/kg, s.c.), buprenorphine (0.01-0.316 mg/kg, s.c.) or a combination of a subeffective dose of tramadol (2 mg/kg) with a subeffective dose of morphine or buprenorphine and the CPP effect was measured. The retention of CPP effect was also examined. Tramadol, morphine and buprenorphine all produced a dose-dependent and significant CPP. A smaller dose of tramadol (2 mg/kg) enhanced morphine- and buprenorphine-induced CPP and shifted the dose-effect curves of both drugs leftward. In addition, the combination of tramadol with morphine or buprenorphine prolonged the retention of CPP. These findings indicate that tramadol potentiates the rewarding effects of morphine or buprenorphine largely in an additive manner and support the general contention that tramadol has relatively low abuse liability. (c) 2012 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
所属项目编号: 30870894 ; 2009CB522000 ; 2011BAK04B08
项目资助者: National Nature Science Foundation of China ; National Basic Research Program of China ; National Key Technology R &amp ; D Program in the 12th Five Year Plan of China
WOS记录号: WOS:000306027300018
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52299
Appears in Collections:中国药物依赖性研究所_期刊论文

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作者单位: 1.Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China
2.Tianjin Med Univ, Dept Physiol, Tianjin 300070, Peoples R China
3.SUNY Buffalo, Sch Med & Biomed Sci, Dept Pharmacol & Toxicol, Buffalo, NY 14214 USA

Recommended Citation:
Zhang, Min,Jing, Li,Liu, Qing,et al. Tramadol induces conditioned place preference in rats: Interactions with morphine and buprenorphine[J]. NEUROSCIENCE LETTERS,2012,520(1):87-91.
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