IR@PKUHSC  > 中国药物依赖性研究所
学科主题药物依赖
Tramadol induces conditioned place preference in rats: Interactions with morphine and buprenorphine
Zhang, Min1; Jing, Li2; Liu, Qing1; Wen, Rui-Ting1; Li, Jun-Xu3; Li, Yu-Ling1; Gong, Qi1; Liang, Jian-Hui1
关键词Tramadol Morphine Buprenorphine Drug Interaction Conditioned Place Preference
刊名NEUROSCIENCE LETTERS
2012-06-27
DOI10.1016/j.neulet.2012.05.037
520期:1页:87-91
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
资助者National Nature Science Foundation of China ; National Basic Research Program of China ; National Key Technology R &amp ; D Program in the 12th Five Year Plan of China ; National Nature Science Foundation of China ; National Basic Research Program of China ; National Key Technology R &amp ; D Program in the 12th Five Year Plan of China
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]MU-OPIOID-RECEPTOR ; POSTMARKETING SURVEILLANCE ; DISCRIMINATIVE STIMULUS ; ABUSE LIABILITY ; DRUG-DEPENDENCE ; CONSISTENT ; HUMANS ; REWARD ; MICE ; SENSITIZATION
英文摘要

Surveys and drug surveillance have demonstrated that the abuse liability of tramadol is considerably low in the general population but appears to be higher in opiate addicts, and this difference could attribute to the poly-drug abuse of opioid addicts, although this hypothesis has not been tested in the laboratory. The present study examined the interactions between tramadol and a full mu opioid receptor agonist morphine or a partial mu opioid receptor agonist buprenorphine in a conditioned place preference (CPP) paradigm in rats. Rats were conditioned with tramadol (2-54 mg/kg, i.p.), morphine (0.125-8 mg/kg, s.c.), buprenorphine (0.01-0.316 mg/kg, s.c.) or a combination of a subeffective dose of tramadol (2 mg/kg) with a subeffective dose of morphine or buprenorphine and the CPP effect was measured. The retention of CPP effect was also examined. Tramadol, morphine and buprenorphine all produced a dose-dependent and significant CPP. A smaller dose of tramadol (2 mg/kg) enhanced morphine- and buprenorphine-induced CPP and shifted the dose-effect curves of both drugs leftward. In addition, the combination of tramadol with morphine or buprenorphine prolonged the retention of CPP. These findings indicate that tramadol potentiates the rewarding effects of morphine or buprenorphine largely in an additive manner and support the general contention that tramadol has relatively low abuse liability. (c) 2012 Elsevier Ireland Ltd. All rights reserved.

语种英语
所属项目编号30870894 ; 2009CB522000 ; 2011BAK04B08
资助者National Nature Science Foundation of China ; National Basic Research Program of China ; National Key Technology R &amp ; D Program in the 12th Five Year Plan of China ; National Nature Science Foundation of China ; National Basic Research Program of China ; National Key Technology R &amp ; D Program in the 12th Five Year Plan of China
WOS记录号WOS:000306027300018
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52299
Collection中国药物依赖性研究所
作者单位1.Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China
2.Tianjin Med Univ, Dept Physiol, Tianjin 300070, Peoples R China
3.SUNY Buffalo, Sch Med & Biomed Sci, Dept Pharmacol & Toxicol, Buffalo, NY 14214 USA
Recommended Citation
GB/T 7714
Zhang, Min,Jing, Li,Liu, Qing,et al. Tramadol induces conditioned place preference in rats: Interactions with morphine and buprenorphine[J]. NEUROSCIENCE LETTERS,2012,520(1):87-91.
APA Zhang, Min.,Jing, Li.,Liu, Qing.,Wen, Rui-Ting.,Li, Jun-Xu.,...&Liang, Jian-Hui.(2012).Tramadol induces conditioned place preference in rats: Interactions with morphine and buprenorphine.NEUROSCIENCE LETTERS,520(1),87-91.
MLA Zhang, Min,et al."Tramadol induces conditioned place preference in rats: Interactions with morphine and buprenorphine".NEUROSCIENCE LETTERS 520.1(2012):87-91.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
谷歌学术
谷歌学术Similar articles in
[Zhang, Min]'s Articles
[Jing, Li]'s Articles
[Liu, Qing]'s Articles
百度学术
百度学术Similar articles in
[Zhang, Min]'s Articles
[Jing, Li]'s Articles
[Liu, Qing]'s Articles
必应学术
必应学术Similar articles in
[Zhang, Min]'s Articles
[Jing, Li]'s Articles
[Liu, Qing]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.