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Tramadol induces conditioned place preference in rats: Interactions with morphine and buprenorphine
Zhang, Min1; Jing, Li2; Liu, Qing1; Wen, Rui-Ting1; Li, Jun-Xu3; Li, Yu-Ling1; Gong, Qi1; Liang, Jian-Hui1
关键词Tramadol Morphine Buprenorphine Drug Interaction Conditioned Place Preference
刊名NEUROSCIENCE LETTERS
2012-06-27
DOI10.1016/j.neulet.2012.05.037
520期:1页:87-91
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]MU-OPIOID-RECEPTOR ; POSTMARKETING SURVEILLANCE ; DISCRIMINATIVE STIMULUS ; ABUSE LIABILITY ; DRUG-DEPENDENCE ; CONSISTENT ; HUMANS ; REWARD ; MICE ; SENSITIZATION
英文摘要

Surveys and drug surveillance have demonstrated that the abuse liability of tramadol is considerably low in the general population but appears to be higher in opiate addicts, and this difference could attribute to the poly-drug abuse of opioid addicts, although this hypothesis has not been tested in the laboratory. The present study examined the interactions between tramadol and a full mu opioid receptor agonist morphine or a partial mu opioid receptor agonist buprenorphine in a conditioned place preference (CPP) paradigm in rats. Rats were conditioned with tramadol (2-54 mg/kg, i.p.), morphine (0.125-8 mg/kg, s.c.), buprenorphine (0.01-0.316 mg/kg, s.c.) or a combination of a subeffective dose of tramadol (2 mg/kg) with a subeffective dose of morphine or buprenorphine and the CPP effect was measured. The retention of CPP effect was also examined. Tramadol, morphine and buprenorphine all produced a dose-dependent and significant CPP. A smaller dose of tramadol (2 mg/kg) enhanced morphine- and buprenorphine-induced CPP and shifted the dose-effect curves of both drugs leftward. In addition, the combination of tramadol with morphine or buprenorphine prolonged the retention of CPP. These findings indicate that tramadol potentiates the rewarding effects of morphine or buprenorphine largely in an additive manner and support the general contention that tramadol has relatively low abuse liability. (c) 2012 Elsevier Ireland Ltd. All rights reserved.

语种英语
WOS记录号WOS:000306027300018
项目编号30870894 ; 2009CB522000 ; 2011BAK04B08
资助机构National Nature Science Foundation of China ; National Basic Research Program of China ; National Key Technology R &amp ; D Program in the 12th Five Year Plan of China
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52299
专题中国药物依赖性研究所
北京大学药学院_分子与细胞药理学系
北京大学第二临床医学院_药剂科
作者单位1.Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China
2.Tianjin Med Univ, Dept Physiol, Tianjin 300070, Peoples R China
3.SUNY Buffalo, Sch Med & Biomed Sci, Dept Pharmacol & Toxicol, Buffalo, NY 14214 USA
推荐引用方式
GB/T 7714
Zhang, Min,Jing, Li,Liu, Qing,et al. Tramadol induces conditioned place preference in rats: Interactions with morphine and buprenorphine[J]. NEUROSCIENCE LETTERS,2012,520(1):87-91.
APA Zhang, Min.,Jing, Li.,Liu, Qing.,Wen, Rui-Ting.,Li, Jun-Xu.,...&Liang, Jian-Hui.(2012).Tramadol induces conditioned place preference in rats: Interactions with morphine and buprenorphine.NEUROSCIENCE LETTERS,520(1),87-91.
MLA Zhang, Min,et al."Tramadol induces conditioned place preference in rats: Interactions with morphine and buprenorphine".NEUROSCIENCE LETTERS 520.1(2012):87-91.
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