|Correlation of E-selectin gene polymorphisms with risk of ischemic stroke A meta-analysis|
|Sun, Qingli; Fu, Yu; Sun, Aping; Shou, Yanhong; Zheng, Mei; Li, Xiaogang; Fan, Dongsheng|
|关键词||E-selectin Ischemic Stroke Gene Polymorphism Meta-analysis|
|刊名||NEURAL REGENERATION RESEARCH|
|WOS标题词||Science & Technology|
|类目[WOS]||Cell Biology ; Neurosciences|
|研究领域[WOS]||Cell Biology ; Neurosciences & Neurology|
|关键词[WOS]||CORONARY-ARTERY-DISEASE ; ADHESION MOLECULES ; S128R POLYMORPHISM ; SER128ARG ; HYPERCHOLESTEROLEMIA ; ASSOCIATION ; EXPRESSION ; GENOTYPE|
OBJECTIVE: To investigate the association of E-selectin S128R polymorphisms with ischemic stroke.
DATA SOURCES: A computer-based online search was conducted in PubMed, Elsevier, Ovid Database, the China National Knowledge Infrastructure, and Wanfang Database between January 1998 and December 2010.
STUDY SELECTION: Case-controlled studies addressing the association of the E-selectin polymorphism and ischemic stroke were included in this review. The genotype distribution complied with the Hardy-Weinberg genetic equilibrium. The included reports were evaluated by two authors for strict quality screening. Meta-analysis software, REVMAN 5.1, was used to investigate heterogeneity, pooled odds ratio (OR) and 95% confidence interval (CI) in individual studies.
MAIN OUTCOME MEASURES: Genotype and allele distributions at the E-selectin S128R site.
RESULTS: Six case-controlled studies were included after screening and application of inclusion and exclusion criteria. There was no heterogeneity in the genotype and allele frequencies, and no publication bias was found. Meta-analysis of the pooled data showed that the OR value of the (AC+CC)/AA genotype was 1.93 (95% CI: 1.55-2.41, Z = 5.80, P < 0.000 01), and the OR for the C/A allele was 1.80 (95% CI: 1.47-2.22, Z = 5.59, P < 0.000 01) in the ischemic stroke group, compared with control group. Results of pooled data in Chinese subjects showed that the OR value of (AC+CC)/AA was 2.36 (95% CI: 1.68-3.31, Z = 4.99, P < 0.000 01), and the OR value of the C/A allele was 2.25 (95% CI: 1.63-3.12, Z = 4.89, P < 0.000 01).
CONCLUSION: Polymorphism of E-selectin S128R was significantly associated with susceptibility to ischemic stroke; the AC and CC genotypes as well as the C allele may be factors associated with susceptibility to ischemic stroke.
|作者单位||Peking Univ, Hosp 3, Dept Neurol, Beijing 100191, Peoples R China|
|Sun, Qingli,Fu, Yu,Sun, Aping,et al. Correlation of E-selectin gene polymorphisms with risk of ischemic stroke A meta-analysis[J]. NEURAL REGENERATION RESEARCH,2011,6(22):1731-1735.|
|APA||Sun, Qingli.,Fu, Yu.,Sun, Aping.,Shou, Yanhong.,Zheng, Mei.,...&Fan, Dongsheng.(2011).Correlation of E-selectin gene polymorphisms with risk of ischemic stroke A meta-analysis.NEURAL REGENERATION RESEARCH,6(22),1731-1735.|
|MLA||Sun, Qingli,et al."Correlation of E-selectin gene polymorphisms with risk of ischemic stroke A meta-analysis".NEURAL REGENERATION RESEARCH 6.22(2011):1731-1735.|