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学科主题: 精神卫生
题名:
Neuregulin 1 genetic variation and anterior cingulum integrity in patients with schizophrenia and healthy controls
作者: Wang, Fei1,2,3; Jiang, Tianzi2; Sun, Zhiguo4; Teng, Siew-leng5; Luo, Xingguang3; Zhu, Zhongjun1; Zang, Yufeng2; Zhang, Handi1; Yue, Weihua1; Qu, Mei1; Lu, Tianlan1; Hong, Nan4; Huang, Haiyan5; Blumberg, Hilary P.3; Zhang, Dai1
刊名: JOURNAL OF PSYCHIATRY & NEUROSCIENCE
发表日期: 2009-05-01
卷: 34, 期:3, 页:181-186
收录类别: SCI ; SSCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences ; Psychiatry
研究领域[WOS]: Neurosciences & Neurology ; Psychiatry
关键词[WOS]: DIFFUSION TENSOR ; NRG1 GENE ; PREFRONTAL CORTEX ; IN-VIVO ; ASSOCIATION ; POPULATION ; SUSCEPTIBILITY ; ABNORMALITIES ; SUPPORT ; MYELIN
英文摘要:

Background: Neuregulin1 (NRG1) influences the development of white matter connectivity and is implicated in genetic susceptibility to schizophrenia. The cingulum bundle is a white matter structure implicated in schizophrenia. Its anterior component is especially implicated, as it provides reciprocal connections between brain regions with prominent involvement in the disorder. Abnormalities in the structural integrity of the anterior cingulum in patients with schizophrenia have been reported previously. The present study investigated the potential contribution of NRG1 variation to anterior cingulum abnormalities in participants with schizophrenia. Methods: We studied 31 men with schizophrenia and 36 healthy men using diffusion tensor imaging to investigate the association between fractional anisotropy in the anterior cingulum and a single-nucleotide polymorphism (SNP8NRG221533: rs35753505) of NRG1. Results: Consistent with previous reports, fractional anisotropy was significantly reduced in the anterior cingulum in the schizophrenia group. Moreover, the results revealed a significant group (schizophrenia, control) by genotype (C/C, T carriers, including CT and TT) interaction between genetic variation in NRG1 and diagnosis of schizophrenia, such that the patients with the T allele for SNP8NRG221533 had significantly decreased anterior cingulum fractional anisotropy compared with patients homozygous for the C allele and healthy controls who were T carriers. Limitations: Limitations of our study included the small sample size of the TT subgroup and our use of only fractional anisotropy as an index of myelin integrity. In addition, the use of diffusion tensor imaging acquisition methods limited our ability to study other brain regions that may be involved in schizophrenia. Conclusion: Our results suggest that NRG1 variation may play a role in the pathophysiology of anterior cingulum abnormalities in patients with schizophrenia.

语种: 英语
所属项目编号: 30530290 ; 30870896 ; 2006AA02Z195 ; 2007CB512301 ; 2007-1001
项目资助者: National Natural Science Foundation of China ; National High Technology Research and Development Program of China ; National Basic Research Program of China ; Capital Foundation of Medical Developments
WOS记录号: WOS:000265540400003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52305
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Peking Univ, Inst Mental Hlth, Beijing 100083, Peoples R China
2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China
3.Yale Univ, Sch Med, Dept Psychiat, New Haven, CT USA
4.Peking Univ, Peoples Hosp, Dept Radiol, Beijing 100083, Peoples R China
5.Univ Calif Berkeley, Dept Stat, Berkeley, CA 94720 USA

Recommended Citation:
Wang, Fei,Jiang, Tianzi,Sun, Zhiguo,et al. Neuregulin 1 genetic variation and anterior cingulum integrity in patients with schizophrenia and healthy controls[J]. JOURNAL OF PSYCHIATRY & NEUROSCIENCE,2009,34(3):181-186.
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