北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 中国药物依赖性研究所  > 期刊论文
学科主题: 药物依赖
题名:
Role of ERK in cocaine addiction
作者: Lu, Lin1; Koya, Eisuke1; Zhai, Haifeng1; Hope, Bruce T.1; Shaham, Yavin1
刊名: TRENDS IN NEUROSCIENCES
发表日期: 2006-12-01
DOI: 10.1016/j.tins.2006.10.005
卷: 29, 期:12, 页:695-703
收录类别: SCI ; SSCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: SIGNAL-REGULATED KINASE ; MESOLIMBIC DOPAMINE SYSTEM ; BEHAVIORAL SENSITIZATION ; NUCLEUS-ACCUMBENS ; SEEKING BEHAVIOR ; PLACE PREFERENCE ; GENE-EXPRESSION ; MAP KINASE ; TRANSDUCTION CASCADE ; NEOSTRIATAL NEURONS
英文摘要:

Cocaine addiction is characterized by compulsive drug-taking behavior and high rates of relapse. According to recent theories, this addiction is due to drug-induced adaptations in the cellular mechanisms that underlie normal learning and memory. Such mechanisms involve signaling by extracellular signal-regulated kinase (ERK). As we review here, evidence from rodent studies also implicates ERK in cocaine psychomotor sensitization, cocaine reward, consolidation and reconsolidation of memories for cocaine cues, and time-dependent increases in cocaine seeking after withdrawal (incubation of cocaine craving). The role of ERK in these behaviors involves long-term stable alterations in synaptic plasticity that result from repeated cocaine exposure, and also rapidly induced alterations in synaptic transmission events that acutely control cocaine-seeking behaviors. Pharmacological manipulations that decrease the extent to which cocaine and cocaine cues induce ERK activity might therefore be considered as potential treatments for cocaine addiction.

语种: 英语
WOS记录号: WOS:000242948800006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52318
Appears in Collections:中国药物依赖性研究所_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Natl Inst Drug Dependence, Dept Neuropharmacol, Beijing 100083, Peoples R China
2.NIDA, Behav Neurosci Branch, IRP, NIH,DHHS, Baltimore, MD 21224 USA

Recommended Citation:
Lu, Lin,Koya, Eisuke,Zhai, Haifeng,et al. Role of ERK in cocaine addiction[J]. TRENDS IN NEUROSCIENCES,2006,29(12):695-703.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Lu, Lin]'s Articles
[Koya, Eisuke]'s Articles
[Zhai, Haifeng]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Lu, Lin]‘s Articles
[Koya, Eisuke]‘s Articles
[Zhai, Haifeng]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace