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学科主题: 临床医学
题名:
Effects of Icariside II on Corpus Cavernosum and Major Pelvic Ganglion Neuropathy in Streptozotocin-Induced Diabetic Rats
作者: Bai, Guang-Yi1; Zhou, Feng1,2; Hui, Yu2; Xu, Yong-De1; Lei, Hong-En1; Pu, Jin-Xian2; Xin, Zhong-Cheng1
关键词: erectile dysfunction ; diabetes ; neuropathy ; nNOS ; NGF ; major pelvic ganglion ; Icariside II
刊名: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
发表日期: 2014-12-01
DOI: 10.3390/ijms151223294
卷: 15, 期:12, 页:23294-23306
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary
研究领域[WOS]: Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]: IMPROVING ERECTILE FUNCTION ; IN-VITRO ; DYSFUNCTION ; ICARIIN ; PHOSPHODIESTERASE-5 ; GENETICS ; MELLITUS ; THERAPY ; GROWTH ; PDE5
英文摘要:

Diabetic erectile dysfunction is associated with penile dorsal nerve bundle neuropathy in the corpus cavernosum and the mechanism is not well understood. We investigated the neuropathy changes in the corpus cavernosum of rats with streptozotocin-induced diabetes and the effects of Icariside II (ICA II) on improving neuropathy. Thirty-six 8-week-old Sprague-Dawley rats were randomly distributed into normal control group, diabetic group and ICA-II treated group. Diabetes was induced by a one-time intraperitoneal injection of streptozotocin (60 mg/kg). Three days later, the diabetic rats were randomly divided into 2 groups including a saline treated placebo group and an ICA II-treated group (5 mg/kg/day, by intragastric administration daily). Twelve weeks later, erectile function was measured by cavernous nerve electrostimulation with real time intracorporal pressure assessment. The penis was harvested for the histological examination (immunofluorescence and immunohistochemical staining) and transmission electron microscopy detecting. Diabetic animals exhibited a decreased density of dorsal nerve bundle in penis. The neurofilament of the dorsal nerve bundle was fragmented in the diabetic rats. There was a decreased expression of nNOS and NGF in the diabetic group. The ICA II group had higher density of dorsal nerve bundle, higher expression of NGF and nNOS in the penis. The pathological change of major pelvic nerve ganglion (including the microstructure by transmission electron microscope and the neurite outgrowth length of major pelvic nerve ganglion tissue cultured in vitro) was greatly attenuated in the ICA II-treated group (p < 0.01). ICA II treatment attenuates the diabetes-related impairment of corpus cavernosum and major pelvic ganglion neuropathy in rats with Streptozotocin-Induced Diabetes.

语种: 英语
所属项目编号: 81300478 ; 81272531 ; BK20130269 ; H201312 ; SYS201450
项目资助者: National Natural Science Foundation of China ; Natural Science Foundation of Jiangsu Province ; Medical Science Foundation of Jiangsu Province Department of Health ; Science and Technology Development Program of Suzhou
WOS记录号: WOS:000346797400102
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52319
Appears in Collections:北京大学第一临床医学院_男科中心_期刊论文

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作者单位: 1.Peking Univ, Androl Ctr, Hosp 1, Beijing 100034, Peoples R China
2.Soochow Univ, Dept Urol, Affiliated Hosp 1, Suzhou 215006, Peoples R China

Recommended Citation:
Bai, Guang-Yi,Zhou, Feng,Hui, Yu,et al. Effects of Icariside II on Corpus Cavernosum and Major Pelvic Ganglion Neuropathy in Streptozotocin-Induced Diabetic Rats[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2014,15(12):23294-23306.
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