IR@PKUHSC  > 北京大学基础医学院  > 药理学系
学科主题基础医学
Antiplatelet activity of hesperetin, a bioflavonoid, is mainly mediated by inhibition of PLC-gamma 2 phosphorylation and cyclooxygenase-1 activity
Jin, Yong-Ri1; Han, Xiang-Hua1; Zhang, Yong-He1; Lee, Jung-Jin1; Lim, Yong1; Chung, Jin-Ho1; Yun, Yeo-Pyo1
关键词Hesperetin Platelet Aggregation Phospholipase c Cyclooxygenase-1
刊名ATHEROSCLEROSIS
2007-09-01
DOI10.1016/j.atherosclerosis.2006.10.011
194期:1页:144-152
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Peripheral Vascular Disease
研究领域[WOS]Cardiovascular System & Cardiology
关键词[WOS]ARACHIDONIC-ACID METABOLISM ; ACUTE CORONARY SYNDROMES ; PLATELET-AGGREGATION ; HEPATIC CHOLESTEROL ; THROMBUS FORMATION ; A(2) RECEPTOR ; COLLAGEN ; HESPERIDIN ; ACTIVATION ; FLAVONOIDS
英文摘要

Diet can be one of the most important factors that influence risks for atherothrombotic diseases. Hesperetin included in grapefruits and oranges is one candidate that may benefit the cardiovascular system. Here, we investigated antiplatelet activity of hesperefin in vitro. In addition, possible antiplatelet mechanism was also investigated. Hesperetin concentration-dependently inhibited washed rabbit platelet aggregation induced by collagen and arachidonic acid, with IC50 of 20.5 +/- 3.5 and 69.2 +/- 5.1 mu M, respectively, while has little effect on thrombin- or U46619-, a thromboxane (TX) A(2) mimic, mediated platelet aggregation, suggesting that hesperetin may selectively inhibit collagen- and arachidonic acid-mediated signal transduction. In accordance with these findings, hesperetin revealed blocking of the collagen-mediated phospholipase (PL) C-gamma 2 phosphorylation, and caused concentration-dependent decreases of cytosolic calcium mobilization, arachidonic acid liberation and serotonin secretion. In addition, hesperetin inhibited arachidonic acid-mediated platelet aggregation by interfering with cyclooxygenase-1 activity as established by the measurement of arachidonic acid-mediated TXA(2) and prostaglandin D, formations as well as cyclooxygenase- I and TXA2 synthase activity assays. Taken together, the present results provide a cellular mechanism for the antiplatelet activity of hesperetin through inhibition of PLC-gamma 2 phosphorylation and cyclooxygenase-1 activity, which may contribute to the beneficial effects of grapefruits and oranges on cardiovascular system. (C) 2006 Elsevier Ireland Ltd. All rights reserved.

语种英语
WOS记录号WOS:000250738300013
引用统计
被引频次:45[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52321
专题北京大学基础医学院_药理学系
作者单位1.Seoul Natl Univ, Coll Pharm, Seoul 151742, South Korea
2.Chungbuk Natl Univ, Coll Pharm, Cheongju 361763, South Korea
3.Chungbuk Natl Univ, Vet Med Res Inst, Cheongju 361763, South Korea
4.Peking Univ, Sch Basic Med Sci, Dept Pharmacol, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Jin, Yong-Ri,Han, Xiang-Hua,Zhang, Yong-He,et al. Antiplatelet activity of hesperetin, a bioflavonoid, is mainly mediated by inhibition of PLC-gamma 2 phosphorylation and cyclooxygenase-1 activity[J]. ATHEROSCLEROSIS,2007,194(1):144-152.
APA Jin, Yong-Ri.,Han, Xiang-Hua.,Zhang, Yong-He.,Lee, Jung-Jin.,Lim, Yong.,...&Yun, Yeo-Pyo.(2007).Antiplatelet activity of hesperetin, a bioflavonoid, is mainly mediated by inhibition of PLC-gamma 2 phosphorylation and cyclooxygenase-1 activity.ATHEROSCLEROSIS,194(1),144-152.
MLA Jin, Yong-Ri,et al."Antiplatelet activity of hesperetin, a bioflavonoid, is mainly mediated by inhibition of PLC-gamma 2 phosphorylation and cyclooxygenase-1 activity".ATHEROSCLEROSIS 194.1(2007):144-152.
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