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Convergent Evidence from Multimodal Imaging Reveals Amygdala Abnormalities in Schizophrenic Patients and Their First-Degree Relatives
Tian, Lin1,2; Meng, Chun3; Yan, Hao1,2; Zhao, Qiang4; Liu, Qi1,2; Yan, Jun1,2; Han, Yonghua1,2; Yuan, Huishu4; Wang, Lifang1,2; Yue, Weihua1,2; Zhang, Yanbo5; Li, Xinmin5; Zhu, Chaozhe3; He, Yong3; Zhang, Dai1,2
刊名PLOS ONE
2011-12-08
DOI10.1371/journal.pone.0028794
6期:12
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]STATE FUNCTIONAL CONNECTIVITY ; VOXEL-BASED MORPHOMETRY ; HIGH-RISK ; HIPPOCAMPAL VOLUME ; PSYCHIATRIC-DISORDERS ; NONPSYCHOTIC SIBLINGS ; SYNAPTIC PLASTICITY ; EMOTION PERCEPTION ; BRAIN VOLUMES ; FMRI
英文摘要

Background: Shared neuropathological features between schizophrenic patients and their first-degree relatives have potential as indicators of genetic vulnerability to schizophrenia. We sought to explore genetic influences on brain morphology and function in schizophrenic patients and their relatives.

Methods: Using a multimodal imaging strategy, we studied 33 schizophrenic patients, 55 of their unaffected parents, 30 healthy controls for patients, and 29 healthy controls for parents with voxel-based morphometry of structural MRI scans and functional connectivity analysis of resting-state functional MRI data.

Results: Schizophrenic patients showed widespread gray matter reductions in the bilateral frontal cortices, bilateral insulae, bilateral occipital cortices, left amygdala and right thalamus, whereas their parents showed more localized reductions in the left amygdala, left thalamus and right orbitofrontal cortex. Patients and their parents shared gray matter loss in the left amygdala. Further investigation of the resting-state functional connectivity of the amygdala in the patients showed abnormal functional connectivity with the bilateral orbitofrontal cortices, bilateral precunei, bilateral dorsolateral frontal cortices and right insula. Their parents showed slightly less, but similar changes in the pattern in the amygdala connectivity. Co-occurrences of abnormal connectivity of the left amygdala with the left orbitofrontal cortex, right dorsolateral frontal cortex and right precuneus were observed in schizophrenic patients and their parents.

Conclusions: Our findings suggest a potential genetic influence on structural and functional abnormalities of the amygdala in schizophrenia. Such information could help future efforts to identify the endophenotypes that characterize the complex disorder of schizophrenia.

语种英语
WOS记录号WOS:000298163600043
项目编号2011CB707805 ; 2007CB512301 ; 81071088 ; 81000580 ; 2010DFB30820 ; 2007-1001
资助机构National Basic Research Program of China ; National Natural Science Foundation of China ; International Science &amp ; Technology Cooperation Program of China ; Capital Foundation of Medical Developments
引用统计
被引频次:22[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52323
专题北京大学精神卫生研究所
北京大学第一临床医学院_妇产科
北京大学精神卫生研究所_精神科
作者单位1.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
2.Minist Hlth, Key Lab Mental Hlth, Beijing, Peoples R China
3.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China
4.Peking Univ, Dept Radiol, Hosp 3, Beijing 100871, Peoples R China
5.Univ Manitoba, Dept Psychiat, Fac Med, Winnipeg, MB R3T 2N2, Canada
推荐引用方式
GB/T 7714
Tian, Lin,Meng, Chun,Yan, Hao,et al. Convergent Evidence from Multimodal Imaging Reveals Amygdala Abnormalities in Schizophrenic Patients and Their First-Degree Relatives[J]. PLOS ONE,2011,6(12).
APA Tian, Lin.,Meng, Chun.,Yan, Hao.,Zhao, Qiang.,Liu, Qi.,...&Zhang, Dai.(2011).Convergent Evidence from Multimodal Imaging Reveals Amygdala Abnormalities in Schizophrenic Patients and Their First-Degree Relatives.PLOS ONE,6(12).
MLA Tian, Lin,et al."Convergent Evidence from Multimodal Imaging Reveals Amygdala Abnormalities in Schizophrenic Patients and Their First-Degree Relatives".PLOS ONE 6.12(2011).
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