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学科主题: 精神卫生
题名:
Convergent Evidence from Multimodal Imaging Reveals Amygdala Abnormalities in Schizophrenic Patients and Their First-Degree Relatives
作者: Tian, Lin1,2; Meng, Chun3; Yan, Hao1,2; Zhao, Qiang4; Liu, Qi1,2; Yan, Jun1,2; Han, Yonghua1,2; Yuan, Huishu4; Wang, Lifang1,2; Yue, Weihua1,2; Zhang, Yanbo5; Li, Xinmin5; Zhu, Chaozhe3; He, Yong3; Zhang, Dai1,2
刊名: PLOS ONE
发表日期: 2011-12-08
DOI: 10.1371/journal.pone.0028794
卷: 6, 期:12
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: STATE FUNCTIONAL CONNECTIVITY ; VOXEL-BASED MORPHOMETRY ; HIGH-RISK ; HIPPOCAMPAL VOLUME ; PSYCHIATRIC-DISORDERS ; NONPSYCHOTIC SIBLINGS ; SYNAPTIC PLASTICITY ; EMOTION PERCEPTION ; BRAIN VOLUMES ; FMRI
英文摘要:

Background: Shared neuropathological features between schizophrenic patients and their first-degree relatives have potential as indicators of genetic vulnerability to schizophrenia. We sought to explore genetic influences on brain morphology and function in schizophrenic patients and their relatives.

Methods: Using a multimodal imaging strategy, we studied 33 schizophrenic patients, 55 of their unaffected parents, 30 healthy controls for patients, and 29 healthy controls for parents with voxel-based morphometry of structural MRI scans and functional connectivity analysis of resting-state functional MRI data.

Results: Schizophrenic patients showed widespread gray matter reductions in the bilateral frontal cortices, bilateral insulae, bilateral occipital cortices, left amygdala and right thalamus, whereas their parents showed more localized reductions in the left amygdala, left thalamus and right orbitofrontal cortex. Patients and their parents shared gray matter loss in the left amygdala. Further investigation of the resting-state functional connectivity of the amygdala in the patients showed abnormal functional connectivity with the bilateral orbitofrontal cortices, bilateral precunei, bilateral dorsolateral frontal cortices and right insula. Their parents showed slightly less, but similar changes in the pattern in the amygdala connectivity. Co-occurrences of abnormal connectivity of the left amygdala with the left orbitofrontal cortex, right dorsolateral frontal cortex and right precuneus were observed in schizophrenic patients and their parents.

Conclusions: Our findings suggest a potential genetic influence on structural and functional abnormalities of the amygdala in schizophrenia. Such information could help future efforts to identify the endophenotypes that characterize the complex disorder of schizophrenia.

语种: 英语
所属项目编号: 2011CB707805 ; 2007CB512301 ; 81071088 ; 81000580 ; 2010DFB30820 ; 2007-1001
项目资助者: National Basic Research Program of China ; National Natural Science Foundation of China ; International Science &amp ; Technology Cooperation Program of China ; Capital Foundation of Medical Developments
WOS记录号: WOS:000298163600043
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52323
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
2.Minist Hlth, Key Lab Mental Hlth, Beijing, Peoples R China
3.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China
4.Peking Univ, Dept Radiol, Hosp 3, Beijing 100871, Peoples R China
5.Univ Manitoba, Dept Psychiat, Fac Med, Winnipeg, MB R3T 2N2, Canada

Recommended Citation:
Tian, Lin,Meng, Chun,Yan, Hao,et al. Convergent Evidence from Multimodal Imaging Reveals Amygdala Abnormalities in Schizophrenic Patients and Their First-Degree Relatives[J]. PLOS ONE,2011,6(12).
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