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学科主题: 临床医学
题名:
Effects of Icariside II on Improving Erectile Function in Rats With Streptozotocin-Induced Diabetes
作者: Zhou, Feng1; Xin, Hua2; Liu, Tao1; Li, Guang-Yong1; Gao, Zhe-Zhu1; Liu, Jing1; Li, Wei-Ren1; Cui, Wan-Shou1; Bai, Guang-Yi1; Park, Nam Cheol2; Xin, Zhong Cheng1
关键词: Erectile dysfunction ; nitric oxide synthase ; extracellular matrix ; endothelium
刊名: JOURNAL OF ANDROLOGY
发表日期: 2012-09-01
DOI: 10.2164/jandrol.111.015172
卷: 33, 期:5, 页:832-844
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Andrology
研究领域[WOS]: Endocrinology & Metabolism
关键词[WOS]: NITRIC-OXIDE SYNTHASE ; SMOOTH-MUSCLE ; ENDOTHELIAL-CELLS ; IN-VITRO ; DYSFUNCTION ; ICARIIN ; PHOSPHODIESTERASE-5 ; EXPRESSION ; MELLITUS ; PATHOPHYSIOLOGY
英文摘要:

Icariin and icariside II (ICA II), 2 active components isolated from herba epimedii, have a closely structural relationship. There is evidence that icariin may be useful in the treatment of erectile dysfunction (ED); however, the study on the therapeutic efficacy of ICA II on ED is currently scant. We investigated the effects of ICA II on improving erectile function of rats with streptozocin-induced diabetes. Fifty 8-week-old Sprague-Dawley rats were randomly distributed into normal control and diabetic groups. Diabetes was induced by a one-time intraperitoneal injection of streptozocin (60 mg/kg). Three days later, the diabetic rats were randomly divided into 4 groups including a saline-treated placebo arm and 3 ICA II treated models (1, 5, and 10 mg/kg/d). After 3 months, penile hemodynamics was measured by cavernous nerve electrostimulation (CNE) with real time intracorporal pressure assessment. Penises were harvested with subsequent histological examination (picrosirius red stain, Hart elastin stain, and immunohistochemical stain) and Western blots to explore the expression of the nitric oxide-cyclic guanosine monophosphate (NO-cGMP) and transforming growth factor beta 1 (TGF beta 1)/Smad2 signaling pathways. Diabetes significantly attenuated erectile responses to CNE. Diabetic rats had decreased corpus cavernosum smooth muscle/collagen ratio and endothelial cell content relative to the control group. The ratio of collagen I to III was significantly lower in the corpora of diabetic rats; furthermore, cavernous elastic fibers were fragmented in the diabetic animals. Neuronal nitric oxide synthase (nNOS), endothelial nitric oxide synthase, and vascular endothelial growth factor were expressed at lower levels in the diabetic group; ICA II-treated diabetic rats had higher expression in the penis relative to placebo-treated diabetic animals. Both the TGF beta 1/Smad2/connective tissue growth factor (CTGF) signaling pathway and apoptosis were down-regulated in the penis from ICA II-treated rats. ICA II treatment attenuates diabetes-related impairment of penile hemodynamics, likely by increasing smooth muscle, endothelial function, and nNOS expression. ICA II could alter corpus cavernosum fibrous-muscular pathological structure in diabetic rats, which could be regulated by the TGF beta 1/Smad2/CTGF and NO-cGMP signaling pathways.

语种: 英语
所属项目编号: 30972993 ; Z080507030808011
项目资助者: National Natural Science Foundation of China ; Peking National Natural Science Foundation
WOS记录号: WOS:000308782500010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52330
Appears in Collections:北京大学第一临床医学院_男科中心_期刊论文

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作者单位: 1.Peking Univ, Peking Univ Hosp 1, Androl Ctr, Beijing 100009, Peoples R China
2.Pusan Natl Univ, Sch Med, Dept Urol, Pusan, South Korea

Recommended Citation:
Zhou, Feng,Xin, Hua,Liu, Tao,et al. Effects of Icariside II on Improving Erectile Function in Rats With Streptozotocin-Induced Diabetes[J]. JOURNAL OF ANDROLOGY,2012,33(5):832-844.
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