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Clinical value of hematologic test in predicting tumor response to neoadjuvant chemotherapy with esophageal squamous cell carcinoma
Liu, Yinan1; Chen, Jinfeng1; Shao, Ningsheng2; Feng, Yuan1; Wang, Yuzhao1; Zhang, Lijian1
关键词Esophageal Carcinoma Neoadjuvant Chemotherapy Hematologic Test
刊名WORLD JOURNAL OF SURGICAL ONCOLOGY
2014-02-25
DOI10.1186/1477-7819-12-43
12
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Surgery
资助者Beijing Science New Star Plan ; Beijing Science New Star Plan
研究领域[WOS]Oncology ; Surgery
关键词[WOS]LOCALLY ADVANCED ESOPHAGEAL ; LONG-TERM SURVIVAL ; PHASE-II ; PREOPERATIVE CHEMORADIOTHERAPY ; GASTRIC-CANCER ; ADENOCARCINOMA ; SURGERY ; TRIAL ; OXALIPLATIN ; REGRESSION
英文摘要

Background: To investigate the relationship between hematologic test results and the predictive effect of regression of esophageal cancer after neoadjuvant chemotherapy (NACT), we analyzed pre-NACT hematologic data and their relationship to tumor regression.

Methods: Thirty-eight consecutive patients with locally advanced squamous cell esophageal carcinoma who had undergone two cycles of paclitaxel/carboplatin NACT were enrolled. On the day prior to the first cycle of chemotherapy, hematologic tests, including routine blood test and biochemical examinations, were recorded. All patients were confirmed to have no history of hepatitis. Surgical resection was performed when clinical restaging showed effective regression. Histopathological examination was routinely performed to evaluate the postoperative effects of chemotherapy.

Results: After two cycles of NACT, tumor imaging evaluation showed that 27 of the 38 patients had CR and PR, including 25 patients who underwent radical esophagectomies. Six patients had stable disease and five patients had progressive disease. According to the hematologic test results before NACT, patients with higher white blood cell counts, lymphocyte percentages, mononuclear cell counts, neutrophilic granulocyte counts, and eosinophilic granulocyte counts and lower alanine aminotransferase (ALT) level had a significantly greater opportunity for an effective response.

Conclusion: Basal host immunologic function and hepatic function are associated with tumor response to NACT in patients with esophageal cancer. These parameters may have a certain predictive efficacy on NACT for esophageal squamous cell carcinoma.

语种英语
所属项目编号Z11111005450000
资助者Beijing Science New Star Plan ; Beijing Science New Star Plan
WOS记录号WOS:000335352000001
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52333
专题北京大学临床肿瘤学院_胸外科
作者单位1.Peking Univ, Canc Hosp & Inst, Dept Thorac Surg 2, Minist Educ,Key Lab Carcinogenesis & Translat Res, Beijing 100142, Peoples R China
2.Beijing Inst Basic Med Sci, Dept Biochem & Mol Biol, Beijing 100850, Peoples R China
推荐引用方式
GB/T 7714
Liu, Yinan,Chen, Jinfeng,Shao, Ningsheng,et al. Clinical value of hematologic test in predicting tumor response to neoadjuvant chemotherapy with esophageal squamous cell carcinoma[J]. WORLD JOURNAL OF SURGICAL ONCOLOGY,2014,12.
APA Liu, Yinan,Chen, Jinfeng,Shao, Ningsheng,Feng, Yuan,Wang, Yuzhao,&Zhang, Lijian.(2014).Clinical value of hematologic test in predicting tumor response to neoadjuvant chemotherapy with esophageal squamous cell carcinoma.WORLD JOURNAL OF SURGICAL ONCOLOGY,12.
MLA Liu, Yinan,et al."Clinical value of hematologic test in predicting tumor response to neoadjuvant chemotherapy with esophageal squamous cell carcinoma".WORLD JOURNAL OF SURGICAL ONCOLOGY 12(2014).
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