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学科主题: 临床医学
题名:
Clinical value of hematologic test in predicting tumor response to neoadjuvant chemotherapy with esophageal squamous cell carcinoma
作者: Liu, Yinan1; Chen, Jinfeng1; Shao, Ningsheng2; Feng, Yuan1; Wang, Yuzhao1; Zhang, Lijian1
关键词: Esophageal carcinoma ; Neoadjuvant chemotherapy ; Hematologic test
刊名: WORLD JOURNAL OF SURGICAL ONCOLOGY
发表日期: 2014-02-25
DOI: 10.1186/1477-7819-12-43
卷: 12
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Surgery
研究领域[WOS]: Oncology ; Surgery
关键词[WOS]: LOCALLY ADVANCED ESOPHAGEAL ; LONG-TERM SURVIVAL ; PHASE-II ; PREOPERATIVE CHEMORADIOTHERAPY ; GASTRIC-CANCER ; ADENOCARCINOMA ; SURGERY ; TRIAL ; OXALIPLATIN ; REGRESSION
英文摘要:

Background: To investigate the relationship between hematologic test results and the predictive effect of regression of esophageal cancer after neoadjuvant chemotherapy (NACT), we analyzed pre-NACT hematologic data and their relationship to tumor regression.

Methods: Thirty-eight consecutive patients with locally advanced squamous cell esophageal carcinoma who had undergone two cycles of paclitaxel/carboplatin NACT were enrolled. On the day prior to the first cycle of chemotherapy, hematologic tests, including routine blood test and biochemical examinations, were recorded. All patients were confirmed to have no history of hepatitis. Surgical resection was performed when clinical restaging showed effective regression. Histopathological examination was routinely performed to evaluate the postoperative effects of chemotherapy.

Results: After two cycles of NACT, tumor imaging evaluation showed that 27 of the 38 patients had CR and PR, including 25 patients who underwent radical esophagectomies. Six patients had stable disease and five patients had progressive disease. According to the hematologic test results before NACT, patients with higher white blood cell counts, lymphocyte percentages, mononuclear cell counts, neutrophilic granulocyte counts, and eosinophilic granulocyte counts and lower alanine aminotransferase (ALT) level had a significantly greater opportunity for an effective response.

Conclusion: Basal host immunologic function and hepatic function are associated with tumor response to NACT in patients with esophageal cancer. These parameters may have a certain predictive efficacy on NACT for esophageal squamous cell carcinoma.

语种: 英语
所属项目编号: Z11111005450000
项目资助者: Beijing Science New Star Plan
WOS记录号: WOS:000335352000001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52333
Appears in Collections:北京大学临床肿瘤学院_胸外科_期刊论文

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作者单位: 1.Peking Univ, Canc Hosp & Inst, Dept Thorac Surg 2, Minist Educ,Key Lab Carcinogenesis & Translat Res, Beijing 100142, Peoples R China
2.Beijing Inst Basic Med Sci, Dept Biochem & Mol Biol, Beijing 100850, Peoples R China

Recommended Citation:
Liu, Yinan,Chen, Jinfeng,Shao, Ningsheng,et al. Clinical value of hematologic test in predicting tumor response to neoadjuvant chemotherapy with esophageal squamous cell carcinoma[J]. WORLD JOURNAL OF SURGICAL ONCOLOGY,2014,12.
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