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New sesquiterpenoids from the dried flower buds of Tussilago farfara and their inhibition on NO production in LPS-induced RAW264.7 cells
Li, Wei()1; Huang, Xin()1; Yang, Xiu-Wei()1
关键词TussiL.go Farfara L. Compositae Sesquiterpenoids Nitric Oxide
刊名FITOTERAPIA
2012-03-01
DOI10.1016/j.fitote.2011.11.011
83期:2页:318-322
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]OCCURRING TERPENE DERIVATIVES ; NITRIC-OXIDE ; CONSTITUENTS ; MACROPHAGES ; FLOS
英文摘要

Three new sesquiterpenoids, 1 alpha-(3 ′′-ethyl-cis-crotonoyloxy)-8-angeloyloxy-3 beta,4 beta-epoxybisabola-7(14),10-diene (1), 7 beta-angeloyloxy-14-hydroxy-notonipetranone (2) and 1 alpha-hydroxy-7 beta-(4-methylsenecioyloxy)-oplopa-3(14)Z,8(10)-dien-2-one (3) were isolated from ethanolic extract of the dried flower buds of Tussilago farfara L, along with nine known sesquiterpenoids (4-12). All of these compounds were evaluated for their effect on the inhibition of nitric oxide (NO) production induced by lipopolysaccharide in macrophage cell line RAW 264.7 and exhibited inhibitory activity on NO production in a dose-dependent manner. 7 beta-(4-Methylsenecioyloxy)-oplopa-3(14)E,8(10)-dien-2-one (8) was proved to be the best among these tested sesquiterpenoids with an IC50 value of 10.80 mu M. (C) 2011 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000300817000010
项目编号2011BAI07B08
资助机构National Key Technology R &amp ; D Program of China
引用统计
被引频次:23[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52336
专题北京大学药学院_天然药物学系
作者单位1.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100871, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Dept Nat Med, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Li, Wei,Huang, Xin,Yang, Xiu-Wei. New sesquiterpenoids from the dried flower buds of Tussilago farfara and their inhibition on NO production in LPS-induced RAW264.7 cells[J]. FITOTERAPIA,2012,83(2):318-322.
APA Li, Wei,Huang, Xin,&Yang, Xiu-Wei.(2012).New sesquiterpenoids from the dried flower buds of Tussilago farfara and their inhibition on NO production in LPS-induced RAW264.7 cells.FITOTERAPIA,83(2),318-322.
MLA Li, Wei,et al."New sesquiterpenoids from the dried flower buds of Tussilago farfara and their inhibition on NO production in LPS-induced RAW264.7 cells".FITOTERAPIA 83.2(2012):318-322.
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