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学科主题: 药学
题名:
New sesquiterpenoids from the dried flower buds of Tussilago farfara and their inhibition on NO production in LPS-induced RAW264.7 cells
作者: Li, Wei1; Huang, Xin1; Yang, Xiu-Wei1
关键词: Tussilago farfara L. ; Compositae ; Sesquiterpenoids ; Nitric oxide
刊名: FITOTERAPIA
发表日期: 2012-03-01
DOI: 10.1016/j.fitote.2011.11.011
卷: 83, 期:2, 页:318-322
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: OCCURRING TERPENE DERIVATIVES ; NITRIC-OXIDE ; CONSTITUENTS ; MACROPHAGES ; FLOS
英文摘要:

Three new sesquiterpenoids, 1 alpha-(3 ′′-ethyl-cis-crotonoyloxy)-8-angeloyloxy-3 beta,4 beta-epoxybisabola-7(14),10-diene (1), 7 beta-angeloyloxy-14-hydroxy-notonipetranone (2) and 1 alpha-hydroxy-7 beta-(4-methylsenecioyloxy)-oplopa-3(14)Z,8(10)-dien-2-one (3) were isolated from ethanolic extract of the dried flower buds of Tussilago farfara L, along with nine known sesquiterpenoids (4-12). All of these compounds were evaluated for their effect on the inhibition of nitric oxide (NO) production induced by lipopolysaccharide in macrophage cell line RAW 264.7 and exhibited inhibitory activity on NO production in a dose-dependent manner. 7 beta-(4-Methylsenecioyloxy)-oplopa-3(14)E,8(10)-dien-2-one (8) was proved to be the best among these tested sesquiterpenoids with an IC50 value of 10.80 mu M. (C) 2011 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 2011BAI07B08
项目资助者: National Key Technology R &amp ; D Program of China
WOS记录号: WOS:000300817000010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52336
Appears in Collections:北京大学药学院_天然药物学系_期刊论文

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作者单位: 1.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100871, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Dept Nat Med, Beijing 100871, Peoples R China

Recommended Citation:
Li, Wei,Huang, Xin,Yang, Xiu-Wei. New sesquiterpenoids from the dried flower buds of Tussilago farfara and their inhibition on NO production in LPS-induced RAW264.7 cells[J]. FITOTERAPIA,2012,83(2):318-322.
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