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学科主题: 临床医学
题名:
Kinetics of serum HBsAg in Chinese patients with chronic HBV infection with long-term adefovir dipivoxil treatment
作者: Li Minran; Xi Hongli; Wang Qinhuan; Hou Fengqin; Huo Na; Zhang Xiaxia; Li Fang; Xu Xiaoyuan
关键词: hepatitis B virus ; hepatitis B surface antigen ; adefovir dipivoxil
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2014-06-05
DOI: 10.3760/cma.j.issn.0366-6999.20132826
卷: 127, 期:11, 页:2101-2104
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: CHRONIC HEPATITIS-B ; SURFACE-ANTIGEN ; TREATMENT RESPONSE ; GENOTYPE D ; VIRUS ; THERAPY ; REDUCTION ; INTERFERON ; CARRIERS ; DECLINE
英文摘要:

Background Knowledge on Hepatitis B surface antigen (HBsAg) kinetics in chronic hepatitis B (CHB) patients with long-term adefovir dipivoxil (ADV) treatment is limited. The aims of this study were to investigate HBsAg kinetics in patients with chronic hepatitis B virus (HBV) infection treated with long-term ADV and to evaluate different characteristics between patients with and without HBsAg loss.

Methods We retrospectively evaluated HBsAg kinetics in 24 Chinese patients with chronic HBV infection who achieved continuous virologic suppression during ADV therapy. HBV genotype was determined at baseline. Liver biochemistry, hepatitis B e antigen status, serum HBV DNA, and HBsAg levels were measured at baseline, 6 months, and once every year thereafter.

Results Of these 24 patients, 3, 1, and 20 patients were followed up for 3, 5, and 6 years, respectively. Baseline serum HBsAg level had a moderate correlation with baseline HBV DNA level (r=0.52, P=0.01). The median rate of HBsAg reduction during the therapy period was 0.08 Ig IU.ml(-1).y(-1). Baseline serum HBsAg level was significantly higher than other time points (P ranges from 0.046 to 0.002). The HBsAg reduction rate during the first year was similar to that in other years (P>0.05). The HBsAg reduction rate during the first year in patients with eventual HBsAg loss was significantly faster than that in patients without HBsAg loss (P=0.005).

Conclusions Serum HBsAg levels in Chinese CHB patients receiving long-term ADV demonstrated a gradual reduction. Patients with eventual HBsAg loss had a significantly faster HBsAg reduction rate during the first year than those without HBsAg loss.

语种: 英语
所属项目编号: 2012ZX10002 003-004-003 ; 2013 ZX10002004-001-003 ; D121100003912003
项目资助者: 12th Five-Year Plan ; Beijing Municipal Science and Technology Commission of Major Projects
WOS记录号: WOS:000339034300021
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52337
Appears in Collections:北京大学第一临床医学院_感染疾病科_期刊论文

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作者单位: Peking Univ, Hosp 1, Dept Infect Dis, Beijing 100034, Peoples R China

Recommended Citation:
Li Minran,Xi Hongli,Wang Qinhuan,et al. Kinetics of serum HBsAg in Chinese patients with chronic HBV infection with long-term adefovir dipivoxil treatment[J]. CHINESE MEDICAL JOURNAL,2014,127(11):2101-2104.
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