|Kinetics of serum HBsAg in Chinese patients with chronic HBV infection with long-term adefovir dipivoxil treatment|
|Li Minran; Xi Hongli; Wang Qinhuan; Hou Fengqin; Huo Na; Zhang Xiaxia; Li Fang; Xu Xiaoyuan|
|关键词||Hepatitis b Virus Hepatitis b Surface Antigen Adefovir Dipivoxil|
|刊名||CHINESE MEDICAL JOURNAL|
|WOS标题词||Science & Technology|
|类目[WOS]||Medicine, General & Internal|
|研究领域[WOS]||General & Internal Medicine|
|关键词[WOS]||CHRONIC HEPATITIS-B ; SURFACE-ANTIGEN ; TREATMENT RESPONSE ; GENOTYPE D ; VIRUS ; THERAPY ; REDUCTION ; INTERFERON ; CARRIERS ; DECLINE|
Background Knowledge on Hepatitis B surface antigen (HBsAg) kinetics in chronic hepatitis B (CHB) patients with long-term adefovir dipivoxil (ADV) treatment is limited. The aims of this study were to investigate HBsAg kinetics in patients with chronic hepatitis B virus (HBV) infection treated with long-term ADV and to evaluate different characteristics between patients with and without HBsAg loss.
Methods We retrospectively evaluated HBsAg kinetics in 24 Chinese patients with chronic HBV infection who achieved continuous virologic suppression during ADV therapy. HBV genotype was determined at baseline. Liver biochemistry, hepatitis B e antigen status, serum HBV DNA, and HBsAg levels were measured at baseline, 6 months, and once every year thereafter.
Results Of these 24 patients, 3, 1, and 20 patients were followed up for 3, 5, and 6 years, respectively. Baseline serum HBsAg level had a moderate correlation with baseline HBV DNA level (r=0.52, P=0.01). The median rate of HBsAg reduction during the therapy period was 0.08 Ig IU.ml(-1).y(-1). Baseline serum HBsAg level was significantly higher than other time points (P ranges from 0.046 to 0.002). The HBsAg reduction rate during the first year was similar to that in other years (P>0.05). The HBsAg reduction rate during the first year in patients with eventual HBsAg loss was significantly faster than that in patients without HBsAg loss (P=0.005).
Conclusions Serum HBsAg levels in Chinese CHB patients receiving long-term ADV demonstrated a gradual reduction. Patients with eventual HBsAg loss had a significantly faster HBsAg reduction rate during the first year than those without HBsAg loss.
|项目编号||2012ZX10002 003-004-003 ; 2013 ZX10002004-001-003 ; D121100003912003|
|资助机构||12th Five-Year Plan ; Beijing Municipal Science and Technology Commission of Major Projects|
|作者单位||Peking Univ, Hosp 1, Dept Infect Dis, Beijing 100034, Peoples R China|
|Li Minran,Xi Hongli,Wang Qinhuan,et al. Kinetics of serum HBsAg in Chinese patients with chronic HBV infection with long-term adefovir dipivoxil treatment[J]. CHINESE MEDICAL JOURNAL,2014,127(11):2101-2104.|
|APA||Li Minran.,Xi Hongli.,Wang Qinhuan.,Hou Fengqin.,Huo Na.,...&Xu Xiaoyuan.(2014).Kinetics of serum HBsAg in Chinese patients with chronic HBV infection with long-term adefovir dipivoxil treatment.CHINESE MEDICAL JOURNAL,127(11),2101-2104.|
|MLA||Li Minran,et al."Kinetics of serum HBsAg in Chinese patients with chronic HBV infection with long-term adefovir dipivoxil treatment".CHINESE MEDICAL JOURNAL 127.11(2014):2101-2104.|