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学科主题临床医学
Kinetics of serum HBsAg in Chinese patients with chronic HBV infection with long-term adefovir dipivoxil treatment
Li Minran; Xi Hongli; Wang Qinhuan; Hou Fengqin; Huo Na; Zhang Xiaxia; Li Fang; Xu Xiaoyuan
关键词Hepatitis b Virus Hepatitis b Surface Antigen Adefovir Dipivoxil
刊名CHINESE MEDICAL JOURNAL
2014-06-05
DOI10.3760/cma.j.issn.0366-6999.20132826
127期:11页:2101-2104
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]CHRONIC HEPATITIS-B ; SURFACE-ANTIGEN ; TREATMENT RESPONSE ; GENOTYPE D ; VIRUS ; THERAPY ; REDUCTION ; INTERFERON ; CARRIERS ; DECLINE
英文摘要

Background Knowledge on Hepatitis B surface antigen (HBsAg) kinetics in chronic hepatitis B (CHB) patients with long-term adefovir dipivoxil (ADV) treatment is limited. The aims of this study were to investigate HBsAg kinetics in patients with chronic hepatitis B virus (HBV) infection treated with long-term ADV and to evaluate different characteristics between patients with and without HBsAg loss.

Methods We retrospectively evaluated HBsAg kinetics in 24 Chinese patients with chronic HBV infection who achieved continuous virologic suppression during ADV therapy. HBV genotype was determined at baseline. Liver biochemistry, hepatitis B e antigen status, serum HBV DNA, and HBsAg levels were measured at baseline, 6 months, and once every year thereafter.

Results Of these 24 patients, 3, 1, and 20 patients were followed up for 3, 5, and 6 years, respectively. Baseline serum HBsAg level had a moderate correlation with baseline HBV DNA level (r=0.52, P=0.01). The median rate of HBsAg reduction during the therapy period was 0.08 Ig IU.ml(-1).y(-1). Baseline serum HBsAg level was significantly higher than other time points (P ranges from 0.046 to 0.002). The HBsAg reduction rate during the first year was similar to that in other years (P>0.05). The HBsAg reduction rate during the first year in patients with eventual HBsAg loss was significantly faster than that in patients without HBsAg loss (P=0.005).

Conclusions Serum HBsAg levels in Chinese CHB patients receiving long-term ADV demonstrated a gradual reduction. Patients with eventual HBsAg loss had a significantly faster HBsAg reduction rate during the first year than those without HBsAg loss.

语种英语
WOS记录号WOS:000339034300021
项目编号2012ZX10002 003-004-003 ; 2013 ZX10002004-001-003 ; D121100003912003
资助机构12th Five-Year Plan ; Beijing Municipal Science and Technology Commission of Major Projects
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52337
专题北京大学第一临床医学院_感染疾病科
北京大学医学部管理机构_医学部
作者单位Peking Univ, Hosp 1, Dept Infect Dis, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Li Minran,Xi Hongli,Wang Qinhuan,et al. Kinetics of serum HBsAg in Chinese patients with chronic HBV infection with long-term adefovir dipivoxil treatment[J]. CHINESE MEDICAL JOURNAL,2014,127(11):2101-2104.
APA Li Minran.,Xi Hongli.,Wang Qinhuan.,Hou Fengqin.,Huo Na.,...&Xu Xiaoyuan.(2014).Kinetics of serum HBsAg in Chinese patients with chronic HBV infection with long-term adefovir dipivoxil treatment.CHINESE MEDICAL JOURNAL,127(11),2101-2104.
MLA Li Minran,et al."Kinetics of serum HBsAg in Chinese patients with chronic HBV infection with long-term adefovir dipivoxil treatment".CHINESE MEDICAL JOURNAL 127.11(2014):2101-2104.
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