IR@PKUHSC  > 北京大学第二临床医学院  > 血液科
学科主题临床医学
Non-traditional CD4+CD25-CD69+regulatory T cells are correlated to leukemia relapse after allogeneic hematopoietic stem cell transplantation
Zhao, Xiao-su1; Wang, Xu-hua1; Zhao, Xiang-yu1; Chang, Ying-jun1; Xu, Lan-ping1; Zhang, Xiao-hui1; Huang, Xiao-jun2
关键词Regulatory t Cells Allogeneic Hematopoietic Stem Cell Transplantation Relapse Leukemia Immunoregulatory
刊名JOURNAL OF TRANSLATIONAL MEDICINE
2014-07-01
DOI10.1186/1479-5876-12-187
12
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental
研究领域[WOS]Research & Experimental Medicine
关键词[WOS]VERSUS-HOST-DISEASE ; SUPPRESSOR-CELLS ; REGULATORY CELLS ; TOLERANCE ; INFUSION ; MICE ; IMMUNOTHERAPY ; CD4(+)CD25(+) ; INDUCTION ; DEPLETION
英文摘要

Background: Non-traditional CD4+CD25-CD69+ T cells were found to be involved in disease progression in tumor-bearing mouse models and cancer patients recently. We attempted to define whether this subset of T cells were related to leukemia relapse after allogeneic hematopoietic cell transplantation (allo-HSCT).

Methods: The frequency of CD4+CD25-CD69+ T cells among the CD4+ T cell population from the bone marrow of relapsed patients, patients with positive minimal residual disease (MRD+) and healthy donors was examined by flow cytometry. The CD4+CD25-CD69+ T cells were also stained with the intracellular markers to determine the cytokine (TGF-beta, IL-2 and IL-10) secretion.

Results: The results showed that the frequency of CD4+CD25-CD69 + T cells was markedly increased in patients in the relapsed group and the MRD + group compared to the healthy donor group. The percentage of this subset of T cells was significantly decreased after effective intervention treatment. We also analyzed the reconstitution of CD4+CD25-CD69+ T cells at various time points after allo-HSCT, and the results showed that this subset of T cells reconstituted rapidly and reached a relatively higher level at +60 d in patients compared to controls. The incidence of either MRD+ or relapse in patients with a high frequency of CD4+CD25-CD69+ T cells (>7%) was significantly higher than that of patients with a low frequency of CD4+CD25-CD69+ T cells at +60 d, +90 d and +270 d after transplant. However, our preliminary data indicated that CD4+CD25-CD69+ T cells may not exert immunoregulatory function via cytokine secretion.

Conclusions: This study provides the first clinical evidence of a correlation between non-traditional CD4+CD25-CD69+ Tregs and leukemia relapse after allo-HSCT and suggests that exploration of new methods of adoptive immunotherapy may be beneficial. Further research related to regulatory mechanism behind this phenomenon would be necessary.

语种英语
WOS记录号WOS:000339027000002
项目编号81230013 ; 2011-4022-08 ; Z121107001012085 ; 31200658
资助机构Key Program of National Natural Science Foundation of China ; Scientific Research Foundation for Capital Medicine Development ; Clinical Characteristic Study of Capital Project ; National Natural Science Foundation of China
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52338
专题北京大学第二临床医学院_血液科
作者单位1.Peking Univ, Inst Hematol, Beijing Key Lab Hematopoiet Stem Cell Transplanta, Peoples Hosp, Beijing 100044, Peoples R China
2.Peking Tsinghua Ctr Life Sci, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Zhao, Xiao-su,Wang, Xu-hua,Zhao, Xiang-yu,et al. Non-traditional CD4+CD25-CD69+regulatory T cells are correlated to leukemia relapse after allogeneic hematopoietic stem cell transplantation[J]. JOURNAL OF TRANSLATIONAL MEDICINE,2014,12.
APA Zhao, Xiao-su.,Wang, Xu-hua.,Zhao, Xiang-yu.,Chang, Ying-jun.,Xu, Lan-ping.,...&Huang, Xiao-jun.(2014).Non-traditional CD4+CD25-CD69+regulatory T cells are correlated to leukemia relapse after allogeneic hematopoietic stem cell transplantation.JOURNAL OF TRANSLATIONAL MEDICINE,12.
MLA Zhao, Xiao-su,et al."Non-traditional CD4+CD25-CD69+regulatory T cells are correlated to leukemia relapse after allogeneic hematopoietic stem cell transplantation".JOURNAL OF TRANSLATIONAL MEDICINE 12(2014).
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zhao, Xiao-su]的文章
[Wang, Xu-hua]的文章
[Zhao, Xiang-yu]的文章
百度学术
百度学术中相似的文章
[Zhao, Xiao-su]的文章
[Wang, Xu-hua]的文章
[Zhao, Xiang-yu]的文章
必应学术
必应学术中相似的文章
[Zhao, Xiao-su]的文章
[Wang, Xu-hua]的文章
[Zhao, Xiang-yu]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。