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IR@PKUHSC  > 北京大学第二临床医学院  > 血液科  > 期刊论文
学科主题: 临床医学
题名:
Non-traditional CD4+CD25-CD69+regulatory T cells are correlated to leukemia relapse after allogeneic hematopoietic stem cell transplantation
作者: Zhao, Xiao-su1; Wang, Xu-hua1; Zhao, Xiang-yu1; Chang, Ying-jun1; Xu, Lan-ping1; Zhang, Xiao-hui1; Huang, Xiao-jun2
关键词: Regulatory T cells ; Allogeneic Hematopoietic Stem Cell Transplantation ; Relapse ; Leukemia ; Immunoregulatory
刊名: JOURNAL OF TRANSLATIONAL MEDICINE
发表日期: 2014-07-01
DOI: 10.1186/1479-5876-12-187
卷: 12
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental
研究领域[WOS]: Research & Experimental Medicine
关键词[WOS]: VERSUS-HOST-DISEASE ; SUPPRESSOR-CELLS ; REGULATORY CELLS ; TOLERANCE ; INFUSION ; MICE ; IMMUNOTHERAPY ; CD4(+)CD25(+) ; INDUCTION ; DEPLETION
英文摘要:

Background: Non-traditional CD4+CD25-CD69+ T cells were found to be involved in disease progression in tumor-bearing mouse models and cancer patients recently. We attempted to define whether this subset of T cells were related to leukemia relapse after allogeneic hematopoietic cell transplantation (allo-HSCT).

Methods: The frequency of CD4+CD25-CD69+ T cells among the CD4+ T cell population from the bone marrow of relapsed patients, patients with positive minimal residual disease (MRD+) and healthy donors was examined by flow cytometry. The CD4+CD25-CD69+ T cells were also stained with the intracellular markers to determine the cytokine (TGF-beta, IL-2 and IL-10) secretion.

Results: The results showed that the frequency of CD4+CD25-CD69 + T cells was markedly increased in patients in the relapsed group and the MRD + group compared to the healthy donor group. The percentage of this subset of T cells was significantly decreased after effective intervention treatment. We also analyzed the reconstitution of CD4+CD25-CD69+ T cells at various time points after allo-HSCT, and the results showed that this subset of T cells reconstituted rapidly and reached a relatively higher level at +60 d in patients compared to controls. The incidence of either MRD+ or relapse in patients with a high frequency of CD4+CD25-CD69+ T cells (>7%) was significantly higher than that of patients with a low frequency of CD4+CD25-CD69+ T cells at +60 d, +90 d and +270 d after transplant. However, our preliminary data indicated that CD4+CD25-CD69+ T cells may not exert immunoregulatory function via cytokine secretion.

Conclusions: This study provides the first clinical evidence of a correlation between non-traditional CD4+CD25-CD69+ Tregs and leukemia relapse after allo-HSCT and suggests that exploration of new methods of adoptive immunotherapy may be beneficial. Further research related to regulatory mechanism behind this phenomenon would be necessary.

语种: 英语
所属项目编号: 81230013 ; 2011-4022-08 ; Z121107001012085 ; 31200658
项目资助者: Key Program of National Natural Science Foundation of China ; Scientific Research Foundation for Capital Medicine Development ; Clinical Characteristic Study of Capital Project ; National Natural Science Foundation of China
WOS记录号: WOS:000339027000002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52338
Appears in Collections:北京大学第二临床医学院_血液科_期刊论文

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作者单位: 1.Peking Univ, Inst Hematol, Beijing Key Lab Hematopoiet Stem Cell Transplanta, Peoples Hosp, Beijing 100044, Peoples R China
2.Peking Tsinghua Ctr Life Sci, Beijing 100871, Peoples R China

Recommended Citation:
Zhao, Xiao-su,Wang, Xu-hua,Zhao, Xiang-yu,et al. Non-traditional CD4+CD25-CD69+regulatory T cells are correlated to leukemia relapse after allogeneic hematopoietic stem cell transplantation[J]. JOURNAL OF TRANSLATIONAL MEDICINE,2014,12.
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