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学科主题: 临床医学
题名:
RHINO-ORBITAL-CEREBRAL MYCOSIS AND CAVERNOUS THROMBOSIS
作者: Li, D. M.1,2,3; Shang, P. P.1,2; Zhu, L.4; De Hoog, G. S.3
关键词: rhinocerebral ; orbit ; Alternaria infectoria ; cavernous sinus thrombosis ; mycosis ; mucormycosis ; zygomycosis
刊名: EUROPEAN JOURNAL OF INFLAMMATION
发表日期: 2014
卷: 12, 期:1, 页:1-10
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Immunology
研究领域[WOS]: Immunology
关键词[WOS]: OF-THE-LITERATURE ; RHINOCEREBRAL MUCORMYCOSIS ; ORBITOCEREBRAL MUCORMYCOSIS ; INVASIVE ASPERGILLOSIS ; MYCOTIC-ANEURYSM ; SINUS-THROMBOSIS ; BASILAR ARTERY ; CAROTID-ARTERY ; OPTIC-NERVE ; ZYGOMYCOSIS
英文摘要:

Rhino-orbital-cerebral mycosis (ROCM) is a life-threatening fungal disease associated mostly with Mucoralean fungi. The infection presents as headache, vision loss, proptosis, ptosis, painful ophthalmoplegia, and peripheral face palsy, with a high mortality (>80% for infections that spread to the brain) and severe morbidity, such as eyeball exenteration and vision loss. In our hospital, a 61-year-old woman with diabetes was diagnosed with rhino-orbital-cerebral infection caused by Allternaria infectoria. Cavernous sinus thromboses (CST) were seen in surgery, pathology, and MIRE. She did not respond to potent antifungal therapy until the adding of anti-thrombosis drugs. By analyzing our case, together with the ones that have been published, we realized that fungal thrombosis in the cavernous sinus is the main pathophysiological problem in ROCM that typically shows mass enhancement within the cavernous sinus in radiographic images, thrombosis with characteristics of ischemia and infarction in pathology. Anticoagulation/antithrombus therapy might be helpful in the management of ROCM if potent antifungal treatment does not have effect.

语种: 英语
WOS记录号: WOS:000334651900001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52349
Appears in Collections:北京大学第三临床医学院_皮肤科_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Mycol Lab, Beijing 100191, Peoples R China
2.Cent Bur Schimmelcultures, Utrecht, Netherlands
3.Peking Univ, Hosp 3, Dept Dermatol, Beijing 100191, Peoples R China
4.Peking Univ, Hosp 3, Dept Otorhinolaryngol, Beijing 100191, Peoples R China

Recommended Citation:
Li, D. M.,Shang, P. P.,Zhu, L.,et al. RHINO-ORBITAL-CEREBRAL MYCOSIS AND CAVERNOUS THROMBOSIS[J]. EUROPEAN JOURNAL OF INFLAMMATION,2014,12(1):1-10.
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