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学科主题临床医学
Associations between UGT1A1*6/*28 polymorphisms and irinotecan-induced severe toxicity in Chinese gastric or esophageal cancer patients
Gao, Jing; Zhou, Jun; Li, Yanyan; Peng, Zhi; Li, Yilin; Wang, Xicheng; Shen, Lin
关键词Ugt1a1 Irinotecan Toxicity Gastric Cancer Esophageal Cancer
刊名MEDICAL ONCOLOGY
2013-09-01
DOI10.1007/s12032-013-0630-8
30期:3
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
资助者National Natural Science Foundation of China ; Beijing Municipal Science and Technology Commission Program ; National Natural Science Foundation of China ; Beijing Municipal Science and Technology Commission Program
研究领域[WOS]Oncology
关键词[WOS]METASTATIC COLORECTAL-CANCER ; PHASE-II TRIAL ; COMBINATION CHEMOTHERAPY ; THERAPY ; FOLFIRI ; ADENOCARCINOMA ; FLUOROURACIL ; OXALIPLATIN ; LEUCOVORIN ; CARCINOMA
英文摘要

The aim of this study was to investigate the associations between UDP-glucuronosyltransferase (UGT) 1A1 polymorphisms and irinotecan-induced toxicities in Chinese advanced gastric or esophageal cancer patients. The genotypes of UGT1A1*6 and UGT1A1*28 were analyzed by PCR amplification and Sanger sequencing in 42 gastric and 91 esophageal cancer patients receiving irinotecan-containing chemotherapy. The influences of UGT1A1*6/*28 polymorphisms on severe diarrhea and neutropenia were analyzed. The overall incidence of UGT1A1*6/*28 variants in gastric cancer and esophageal cancer was 38.1 % (GA: 31.0 %; AA: 6.9 %), 28.6 % (TA6/TA7: 26.2 %; TA7/TA7: 2.4 %) and 33.0 % (GA: 28.6 %; AA: 4.4 %), 25.3 % (TA6/TA7: 23.1 %; TA7/TA7: 2.2 %) in our cohort, respectively. A total of 10 patients (gastric cancer: 9.5 %, 4/42; esophageal cancer: 6.6 %, 6/91) had severe diarrhea and 35 patients (gastric cancer: 35.7 %, 15/42; esophageal cancer: 22.0 %, 20/91) had severe neutropenia. Statistic analysis between UGT1A1 genotyping and severe diarrhea was not conducted due to the limited number of patients. For gastric cancer, it seemed that only UGT1A1*6 variant was associated with severe neutropenia (P = 0.042), while among esophageal cancer patients, UGT1A1*6 (P = 0.011) or UGT1A1*28 (P = 0.026) variants were significantly associated with severe neutropenia. UGT1A1*6 variant was closely associated with severe neutropenia both in gastric cancer and in esophageal cancer, but the association between UGT1A1*28 variant and severe neutropenia in gastric and esophageal cancer was not consistent in this study, which would be validated in the future large samples.

语种英语
所属项目编号81172110 ; Z11110706730000
资助者National Natural Science Foundation of China ; Beijing Municipal Science and Technology Commission Program ; National Natural Science Foundation of China ; Beijing Municipal Science and Technology Commission Program
WOS记录号WOS:000323662900001
Citation statistics
Cited Times:9[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52356
Collection北京大学临床肿瘤学院_胃肠肿瘤中心
作者单位Peking Univ Canc Hosp & Inst, Dept Gastrointestinal Oncol, Key Lab Carcinogenesis & Translat Res, Minist Educ, Beijing 100142, Peoples R China
Recommended Citation
GB/T 7714
Gao, Jing,Zhou, Jun,Li, Yanyan,et al. Associations between UGT1A1*6/*28 polymorphisms and irinotecan-induced severe toxicity in Chinese gastric or esophageal cancer patients[J]. MEDICAL ONCOLOGY,2013,30(3).
APA Gao, Jing.,Zhou, Jun.,Li, Yanyan.,Peng, Zhi.,Li, Yilin.,...&Shen, Lin.(2013).Associations between UGT1A1*6/*28 polymorphisms and irinotecan-induced severe toxicity in Chinese gastric or esophageal cancer patients.MEDICAL ONCOLOGY,30(3).
MLA Gao, Jing,et al."Associations between UGT1A1*6/*28 polymorphisms and irinotecan-induced severe toxicity in Chinese gastric or esophageal cancer patients".MEDICAL ONCOLOGY 30.3(2013).
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