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学科主题临床医学
Deterioration of the pharyngo-UES contractile reflex in the elderly
Ren, JL1; Xie, PY1; Lang, IM1; Bardan, E1; Sui, ZM1; Shaker, R1
关键词Upper Esophageal Sphincter Airway Protection Pharyngeal Stimulation
刊名LARYNGOSCOPE
2000-09-01
110期:9页:1563-1566
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental ; Otorhinolaryngology
研究领域[WOS]Research & Experimental Medicine ; Otorhinolaryngology
关键词[WOS]WATER STIMULATION ; ESOPHAGEAL ; PERISTALSIS ; INHIBITION ; HUMANS
英文摘要

Objectives/Hypothesis: Deterioration of aerodigestive tract reflexes such as the esophagoglottal and pharyngoglottal closure reflexes and pharyngeal swallow has been documented in the elderly. However, the effect of aging on the contractile response of the upper esophageal sphincter (UES) to pharyngeal water stimulation has not been studied. The aim of this study was to characterize the pharyngo-UES reflex in the healthy elderly, Methods: We studied nine healthy elderly (77 +/- 1 y [SD]; four men, five women) and nine healthy young volunteers (26 +/- 2 y [SD]; four men, five women). A UES sleeve sensor was used to measure the pressure. We tested pharyngeal stimulation induced by rapid pulse and slow continuous injection of water. Results: The volume of water required to stimulate the pharyngo-UES contractile reflex by rapid pulse injection in the elderly (0.5 +/- 34 0.1 mL) was significantly higher than that in the young (0.1 +/- 0.02 mL) (P < .05). In contrast to young subjects, there was no pressure increase in resting UES pressure observed in the elderly for continuous pharyngeal water infusion. In both young and elderly, the threshold volume for the pharyngo UES contractile reflex was significantly lower than that for pharyngeal swallows. Conclusions: The pharyngo-UES contractile reflex deteriorates with aging, This deterioration is primarily due to abnormalities of the afferent limb of the reflex.

语种英语
WOS记录号WOS:000089127800029
引用统计
被引频次:22[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52357
专题北京大学第一临床医学院_消化科
作者单位1.Chaim Sheba Med Ctr, IL-52621 Tel Hashomer, Israel
2.Med Coll Wisconsin, Dysphagia Inst, Div Gastroenterol & Hepatol, Dept Med, Milwaukee, WI 53226 USA
3.Med Coll Wisconsin, VA Med Ctr, Dept Radiol, Milwaukee, WI 53226 USA
4.Med Coll Wisconsin, VA Med Ctr, Dept Otolaryngol, Milwaukee, WI 53226 USA
5.Beijing Med Univ, Sch Clin Med 1, Dept Gastroenterol, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Ren, JL,Xie, PY,Lang, IM,et al. Deterioration of the pharyngo-UES contractile reflex in the elderly[J]. LARYNGOSCOPE,2000,110(9):1563-1566.
APA Ren, JL,Xie, PY,Lang, IM,Bardan, E,Sui, ZM,&Shaker, R.(2000).Deterioration of the pharyngo-UES contractile reflex in the elderly.LARYNGOSCOPE,110(9),1563-1566.
MLA Ren, JL,et al."Deterioration of the pharyngo-UES contractile reflex in the elderly".LARYNGOSCOPE 110.9(2000):1563-1566.
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