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学科主题: 临床医学
题名:
Deterioration of the pharyngo-UES contractile reflex in the elderly
作者: Ren, JL1; Xie, PY1; Lang, IM1; Bardan, E1; Sui, ZM1; Shaker, R1
关键词: upper esophageal sphincter ; airway protection ; pharyngeal stimulation
刊名: LARYNGOSCOPE
发表日期: 2000-09-01
卷: 110, 期:9, 页:1563-1566
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental ; Otorhinolaryngology
研究领域[WOS]: Research & Experimental Medicine ; Otorhinolaryngology
关键词[WOS]: WATER STIMULATION ; ESOPHAGEAL ; PERISTALSIS ; INHIBITION ; HUMANS
英文摘要:

Objectives/Hypothesis: Deterioration of aerodigestive tract reflexes such as the esophagoglottal and pharyngoglottal closure reflexes and pharyngeal swallow has been documented in the elderly. However, the effect of aging on the contractile response of the upper esophageal sphincter (UES) to pharyngeal water stimulation has not been studied. The aim of this study was to characterize the pharyngo-UES reflex in the healthy elderly, Methods: We studied nine healthy elderly (77 +/- 1 y [SD]; four men, five women) and nine healthy young volunteers (26 +/- 2 y [SD]; four men, five women). A UES sleeve sensor was used to measure the pressure. We tested pharyngeal stimulation induced by rapid pulse and slow continuous injection of water. Results: The volume of water required to stimulate the pharyngo-UES contractile reflex by rapid pulse injection in the elderly (0.5 +/- 34 0.1 mL) was significantly higher than that in the young (0.1 +/- 0.02 mL) (P < .05). In contrast to young subjects, there was no pressure increase in resting UES pressure observed in the elderly for continuous pharyngeal water infusion. In both young and elderly, the threshold volume for the pharyngo UES contractile reflex was significantly lower than that for pharyngeal swallows. Conclusions: The pharyngo-UES contractile reflex deteriorates with aging, This deterioration is primarily due to abnormalities of the afferent limb of the reflex.

语种: 英语
WOS记录号: WOS:000089127800029
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52357
Appears in Collections:北京大学第一临床医学院_消化内科_期刊论文

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作者单位: 1.Chaim Sheba Med Ctr, IL-52621 Tel Hashomer, Israel
2.Med Coll Wisconsin, Dysphagia Inst, Div Gastroenterol & Hepatol, Dept Med, Milwaukee, WI 53226 USA
3.Med Coll Wisconsin, VA Med Ctr, Dept Radiol, Milwaukee, WI 53226 USA
4.Med Coll Wisconsin, VA Med Ctr, Dept Otolaryngol, Milwaukee, WI 53226 USA
5.Beijing Med Univ, Sch Clin Med 1, Dept Gastroenterol, Beijing 100083, Peoples R China

Recommended Citation:
Ren, JL,Xie, PY,Lang, IM,et al. Deterioration of the pharyngo-UES contractile reflex in the elderly[J]. LARYNGOSCOPE,2000,110(9):1563-1566.
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