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学科主题: 临床医学
题名:
GKN1 Inhibits Cell Invasion in Gastric Cancer by Inactivating the NF-kappa B Pathway
作者: Xing, Rui; Li, Wen-Mei; Cui, Jian-Tao; Xia, Nan; Lu, You-Yong
刊名: DISCOVERY MEDICINE
发表日期: 2015-02-01
卷: 103, 页:65-71
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental
研究领域[WOS]: Research & Experimental Medicine
关键词[WOS]: EXPRESSION ; GASTROKINE-1 ; GENE
英文摘要:

Metastasis is a relatively early event and a major cause of death in gastric cancer (GC) patients. Gastrokine 1 (GKN1) is a stomach-specific protein that is normally expressed in gastric mucosa but not in primary tumors or cell lines. We and others have demonstrated that GKN1 inhibits cell growth; however, its role in metastasis is not clear. In this study, we explored the role of GKN1 in cell invasion. Immunohistochemistry (IHC) was used to measure the expression of GKN1 in precancerous lesions and in GCs. The cell invasion assay was employed to examine the effect of GKN1 on cell invasion. The molecular mechanism of GKN1 in inhibiting GC cell invasion in vitro was explored by western blotting. We noted a gradual decrease in GKN1 expression from normal mucosa to dysplastic gastric tissue to GC, and that low GKN1 expression was associated with metastasis (P=0.003). We showed that GKN1 inhibits cell invasion by downregulating MMP2 expression through the NF-kappa B pathway. These results provide molecular evidence that GKN1 inhibits metastasis in GC cells, and indicate that GKN1 is a potential novel therapeutic target for gastric cancer.

语种: 英语
所属项目编号: 81101880 ; XXJH2015037
项目资助者: National Natural Science Foundation of China ; Beijing Nova program
WOS记录号: WOS:000356897300001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52359
Appears in Collections:北京大学临床肿瘤学院_分子肿瘤学研究室_期刊论文

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作者单位: Peking Univ, Mol Oncol Lab, Key Lab Carcinogenesis & Translat Res, Minist Educ,Canc Hosp & Inst, Beijing 100142, Peoples R China

Recommended Citation:
Xing, Rui,Li, Wen-Mei,Cui, Jian-Tao,et al. GKN1 Inhibits Cell Invasion in Gastric Cancer by Inactivating the NF-kappa B Pathway[J]. DISCOVERY MEDICINE,2015,103:65-71.
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