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学科主题临床医学
GKN1 Inhibits Cell Invasion in Gastric Cancer by Inactivating the NF-kappa B Pathway
Xing, Rui; Li, Wen-Mei; Cui, Jian-Tao; Xia, Nan; Lu, You-Yong
刊名DISCOVERY MEDICINE
2015-02-01
103页:65-71
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental
研究领域[WOS]Research & Experimental Medicine
关键词[WOS]EXPRESSION ; GASTROKINE-1 ; GENE
英文摘要

Metastasis is a relatively early event and a major cause of death in gastric cancer (GC) patients. Gastrokine 1 (GKN1) is a stomach-specific protein that is normally expressed in gastric mucosa but not in primary tumors or cell lines. We and others have demonstrated that GKN1 inhibits cell growth; however, its role in metastasis is not clear. In this study, we explored the role of GKN1 in cell invasion. Immunohistochemistry (IHC) was used to measure the expression of GKN1 in precancerous lesions and in GCs. The cell invasion assay was employed to examine the effect of GKN1 on cell invasion. The molecular mechanism of GKN1 in inhibiting GC cell invasion in vitro was explored by western blotting. We noted a gradual decrease in GKN1 expression from normal mucosa to dysplastic gastric tissue to GC, and that low GKN1 expression was associated with metastasis (P=0.003). We showed that GKN1 inhibits cell invasion by downregulating MMP2 expression through the NF-kappa B pathway. These results provide molecular evidence that GKN1 inhibits metastasis in GC cells, and indicate that GKN1 is a potential novel therapeutic target for gastric cancer.

语种英语
WOS记录号WOS:000356897300001
项目编号81101880 ; XXJH2015037
资助机构National Natural Science Foundation of China ; Beijing Nova program
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52359
专题北京大学临床肿瘤学院_分子肿瘤学研究室
北京大学临床肿瘤学院_高技术实验室
作者单位Peking Univ, Mol Oncol Lab, Key Lab Carcinogenesis & Translat Res, Minist Educ,Canc Hosp & Inst, Beijing 100142, Peoples R China
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GB/T 7714
Xing, Rui,Li, Wen-Mei,Cui, Jian-Tao,et al. GKN1 Inhibits Cell Invasion in Gastric Cancer by Inactivating the NF-kappa B Pathway[J]. DISCOVERY MEDICINE,2015,103:65-71.
APA Xing, Rui,Li, Wen-Mei,Cui, Jian-Tao,Xia, Nan,&Lu, You-Yong.(2015).GKN1 Inhibits Cell Invasion in Gastric Cancer by Inactivating the NF-kappa B Pathway.DISCOVERY MEDICINE,103,65-71.
MLA Xing, Rui,et al."GKN1 Inhibits Cell Invasion in Gastric Cancer by Inactivating the NF-kappa B Pathway".DISCOVERY MEDICINE 103(2015):65-71.
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