IR@PKUHSC  > 北京大学公共卫生学院
学科主题公共卫生
Developmental Effects of Dietary Nucleotides in Second-Generation Weaned Rats
Xu, Meihong; Ma, Yi; Xu, Linlin; Xu, Yajun; Li, Yong
关键词Developmental Dietary Nucleotides Safety Sprague-dawley Rat
刊名JOURNAL OF MEDICINAL FOOD
2013-12-01
DOI10.1089/jmf.2013.2790
16期:12页:1146-1152
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal ; Food Science & Technology ; Nutrition & Dietetics
研究领域[WOS]Pharmacology & Pharmacy ; Food Science & Technology ; Nutrition & Dietetics
关键词[WOS]SERUM URIC-ACID ; INFANT FORMULA ; DIARRHEAL DISEASE ; IMMUNE-RESPONSES ; NUTRITION ; RIBONUCLEOTIDES ; MICE ; SUPPLEMENTATION ; NUCLEOSIDES ; REDUCTION
英文摘要

The aim of the present study was to evaluate dietary effects of dietary nucleotides (NTs) on developmental parameters in second-generation Sprague-Dawley rats. Experimental design was set up as six groups, including one control and five nucleotide administered groups, doses ranged from 0.01% to 1.28% nucleotides. First-generation (F0) rats were divided into two terms: (1) fed for 90-day study; (2) mated for offspring (F1). After weaning, each group of second-generation F1 rats was fed the control diet. Evaluating parameters were weight gain and food utilization ratios of rats, hematological and biochemical parameters, and organ pathology. The results showed that there was a greater weight gain and food utilization ratio in weaned rats (F0 and F1). Furthermore, weight gain and food utilization ratios were increased in the first 2 weeks of F1 male and the first week of F1 female rats. There were no significant changes in blood indicators of NT groups with the exception of decrease in aspartate aminotransferase and serum uric acid levels. Overall, it was demonstrated that NT supplements could promote the early growth and development at a 0.01% dose. Although NTs may have cumulative reproductive effects, they were safe even at a high-dose supplementation. Additionally, NT supplementation could promote restoration and optimize liver function.

语种英语
WOS记录号WOS:000328457600011
项目编号2006BAD27B08
资助机构Foundation from the Ministry of Science and Technology of the People&prime ; s Republic of China
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52361
专题北京大学公共卫生学院
北京大学公共卫生学院_营养与食品卫生学系
北京大学公共卫生学院_公共卫生学院
作者单位Peking Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Xu, Meihong,Ma, Yi,Xu, Linlin,et al. Developmental Effects of Dietary Nucleotides in Second-Generation Weaned Rats[J]. JOURNAL OF MEDICINAL FOOD,2013,16(12):1146-1152.
APA Xu, Meihong,Ma, Yi,Xu, Linlin,Xu, Yajun,&Li, Yong.(2013).Developmental Effects of Dietary Nucleotides in Second-Generation Weaned Rats.JOURNAL OF MEDICINAL FOOD,16(12),1146-1152.
MLA Xu, Meihong,et al."Developmental Effects of Dietary Nucleotides in Second-Generation Weaned Rats".JOURNAL OF MEDICINAL FOOD 16.12(2013):1146-1152.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Xu, Meihong]的文章
[Ma, Yi]的文章
[Xu, Linlin]的文章
百度学术
百度学术中相似的文章
[Xu, Meihong]的文章
[Ma, Yi]的文章
[Xu, Linlin]的文章
必应学术
必应学术中相似的文章
[Xu, Meihong]的文章
[Ma, Yi]的文章
[Xu, Linlin]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。