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学科主题: 公共卫生
题名:
Developmental Effects of Dietary Nucleotides in Second-Generation Weaned Rats
作者: Xu, Meihong; Ma, Yi; Xu, Linlin; Xu, Yajun; Li, Yong
关键词: developmental ; dietary nucleotides ; safety ; Sprague-Dawley rat
刊名: JOURNAL OF MEDICINAL FOOD
发表日期: 2013-12-01
DOI: 10.1089/jmf.2013.2790
卷: 16, 期:12, 页:1146-1152
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Medicinal ; Food Science & Technology ; Nutrition & Dietetics
研究领域[WOS]: Pharmacology & Pharmacy ; Food Science & Technology ; Nutrition & Dietetics
关键词[WOS]: SERUM URIC-ACID ; INFANT FORMULA ; DIARRHEAL DISEASE ; IMMUNE-RESPONSES ; NUTRITION ; RIBONUCLEOTIDES ; MICE ; SUPPLEMENTATION ; NUCLEOSIDES ; REDUCTION
英文摘要:

The aim of the present study was to evaluate dietary effects of dietary nucleotides (NTs) on developmental parameters in second-generation Sprague-Dawley rats. Experimental design was set up as six groups, including one control and five nucleotide administered groups, doses ranged from 0.01% to 1.28% nucleotides. First-generation (F0) rats were divided into two terms: (1) fed for 90-day study; (2) mated for offspring (F1). After weaning, each group of second-generation F1 rats was fed the control diet. Evaluating parameters were weight gain and food utilization ratios of rats, hematological and biochemical parameters, and organ pathology. The results showed that there was a greater weight gain and food utilization ratio in weaned rats (F0 and F1). Furthermore, weight gain and food utilization ratios were increased in the first 2 weeks of F1 male and the first week of F1 female rats. There were no significant changes in blood indicators of NT groups with the exception of decrease in aspartate aminotransferase and serum uric acid levels. Overall, it was demonstrated that NT supplements could promote the early growth and development at a 0.01% dose. Although NTs may have cumulative reproductive effects, they were safe even at a high-dose supplementation. Additionally, NT supplementation could promote restoration and optimize liver function.

语种: 英语
所属项目编号: 2006BAD27B08
项目资助者: Foundation from the Ministry of Science and Technology of the People&prime ; s Republic of China
WOS记录号: WOS:000328457600011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52361
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: Peking Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Beijing 100191, Peoples R China

Recommended Citation:
Xu, Meihong,Ma, Yi,Xu, Linlin,et al. Developmental Effects of Dietary Nucleotides in Second-Generation Weaned Rats[J]. JOURNAL OF MEDICINAL FOOD,2013,16(12):1146-1152.
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