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学科主题: 基础医学
题名:
Apak competes with p53 for direct binding to intron 1 of p53AIP1 to regulate apoptosis
作者: Yuan, Lin1,2,3; Tian, Chunyan2,3; Wang, Hongye1,2,3; Song, Shanshan2,3,4,5; Li, Deyang2; Xing, Guichun2,3; Yin, Yuxin6; He, Fuchu2,3; Zhang, Lingqiang1,2,3
关键词: p53 ; p53AIP1 ; transcriptional regulation ; apoptosis ; Apak
刊名: EMBO REPORTS
发表日期: 2012-04-01
DOI: 10.1038/embor.2012.10
卷: 13, 期:4, 页:363-370
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Cell Biology
研究领域[WOS]: Biochemistry & Molecular Biology ; Cell Biology
关键词[WOS]: ZINC-FINGER PROTEIN ; P53-DEPENDENT APOPTOSIS ; DISEASE
英文摘要:

The KRAB-type zinc-finger protein Apak was recently identified as a negative regulator of p53-mediated apoptosis. However, the mechanism of this selective regulation is not fully understood. Here, we show that Apak recognizes the TCTTN2-30 TTGT consensus sequence through its zinc-fingers. This sequence is specifically found in intron 1 of the proapoptotic p53 target gene p53AIP1 and largely overlaps with the p53-binding sequence. Apak competes with p53 for binding to this site to inhibit p53AIP1 expression. Upon DNA damage, Apak dissociates from the DNA, which abolishes its inhibitory effect on p53-mediated apoptosis.

语种: 英语
所属项目编号: 2012CB910702 ; 2011CB910802 ; 2010CB912202 ; 2007CB914601 ; 30871373 ; 31125010 ; 5102034
项目资助者: National Basic Research Programs ; National Natural Science Foundation ; Beijing Natural Science Foundation
WOS记录号: WOS:000302562500020
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52366
Appears in Collections:基础医学院_病理学系_期刊论文

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作者单位: 1.Natl Engn Res Ctr Prot Drugs, Beijing 100850, Peoples R China
2.Anhui Med Univ, Dept Biochem & Mol Biol, Hefei 230032, Anhui, Peoples R China
3.Beijing Inst Radiat Med, Beijing Proteome Res Ctr, State Key Lab Prote, Beijing 100850, Peoples R China
4.Peking Union Med Coll, Beijing 100005, Peoples R China
5.Chinese Acad Med Sci, Inst Basic Med Sci, Dept Med Genet, Beijing 100005, Peoples R China
6.Peking Univ, Sch Basic Med Sci, Dept Pathol, Beijing 100191, Peoples R China

Recommended Citation:
Yuan, Lin,Tian, Chunyan,Wang, Hongye,et al. Apak competes with p53 for direct binding to intron 1 of p53AIP1 to regulate apoptosis[J]. EMBO REPORTS,2012,13(4):363-370.
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