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学科主题: 口腔医学
题名:
Graded Porous beta-Tricalcium Phosphate Scaffolds Enhance Bone Regeneration in Mandible Augmentation
作者: Yang, Jingwen1; Kang, Yunqing2; Browne, Christopher2; Jiang, Ting1; Yang, Yunzhi2,3
关键词: Bone regeneration ; graded pore size ; beta-TCP ; bone augmentation
刊名: JOURNAL OF CRANIOFACIAL SURGERY
发表日期: 2015-03-01
DOI: 10.1097/SCS.0000000000001383
卷: 26, 期:2, 页:E148-E153
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Surgery
研究领域[WOS]: Surgery
关键词[WOS]: ALVEOLAR RIDGE AUGMENTATION ; CANCELLOUS BONE ; HYDROXYLAPATITE ; DELIVERY ; BEHAVIOR ; INGROWTH
英文摘要:

Bone augmentation requires scaffold to promote forming of natural bone structure. Currently, most of the reported bone scaffolds are porous solids with uniform pores. The aim of the current study is to evaluate the effect of a graded porous beta-tricalcium phosphate scaffolds on alveolar bone augmentation. Three groups of scaffoldswere fabricated by a template-casting method: (1) graded porous scaffolds with large pores in the center and small pores at the periphery, (2) scaffolds with large uniform pores, and (3) scaffolds with small uniform pores. Bone augmentation on rabbit mandible was investigated by microcomputed tomography, sequential fluorescent labeling, and histologic examination 3 months after implantation. The result presents that all the scaffold groups maintain their augmented bone height after 3-month observation, whereas the autografting group presents an obvious bone resorption. Microcomputed tomography reveals that the graded porous group has significantly greater volume of new bone (P < 0.05) and similar bone density compared with the uniform pores groups. Bone substance distributes unevenly in all the 3 experimental groups. Greater bone volume can be observed in the area closer to the bone bed. The sequential fluorescent labeling observation reveals robust bone regeneration in the first month and faster bone growth in the graded porous scaffold group than that in the large porous scaffold group. Histologic examinations confirm bone structure in the aspect of distribution, activity, and maturity. We conclude that graded porous designed biodegradable beta-tricalcium phosphate scaffolds are beneficial to promote bone augmentation in the aspect of bone volume.

语种: 英语
所属项目编号: 7133255 ; R01DE021468 ; R01AR057837 ; W81XWH-10-1-0966
项目资助者: Beijing Natural Science Foundation ; NIH ; DOD
WOS记录号: WOS:000350891600029
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52368
Appears in Collections:北京大学口腔医学院_口腔修复科_期刊论文

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作者单位: 1.Stanford Univ, Dept Orthoped Surg, Stanford, CA 94305 USA
2.Stanford Univ, Dept Mat Sci & Engn, Stanford, CA 94305 USA
3.Peking Univ, Dept Prosthodont, Sch & Hosp Stomatol, Beijing 100081, Peoples R China

Recommended Citation:
Yang, Jingwen,Kang, Yunqing,Browne, Christopher,et al. Graded Porous beta-Tricalcium Phosphate Scaffolds Enhance Bone Regeneration in Mandible Augmentation[J]. JOURNAL OF CRANIOFACIAL SURGERY,2015,26(2):E148-E153.
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