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学科主题口腔医学
Graded Porous beta-Tricalcium Phosphate Scaffolds Enhance Bone Regeneration in Mandible Augmentation
Yang, Jingwen1; Kang, Yunqing2; Browne, Christopher2; Jiang, Ting1; Yang, Yunzhi2,3
关键词Bone Regeneration Graded Pore Size Beta-tcp Bone Augmentation
刊名JOURNAL OF CRANIOFACIAL SURGERY
2015-03-01
DOI10.1097/SCS.0000000000001383
26期:2页:E148-E153
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Surgery
资助者Beijing Natural Science Foundation ; NIH ; DOD ; Beijing Natural Science Foundation ; NIH ; DOD
研究领域[WOS]Surgery
关键词[WOS]ALVEOLAR RIDGE AUGMENTATION ; CANCELLOUS BONE ; HYDROXYLAPATITE ; DELIVERY ; BEHAVIOR ; INGROWTH
英文摘要

Bone augmentation requires scaffold to promote forming of natural bone structure. Currently, most of the reported bone scaffolds are porous solids with uniform pores. The aim of the current study is to evaluate the effect of a graded porous beta-tricalcium phosphate scaffolds on alveolar bone augmentation. Three groups of scaffoldswere fabricated by a template-casting method: (1) graded porous scaffolds with large pores in the center and small pores at the periphery, (2) scaffolds with large uniform pores, and (3) scaffolds with small uniform pores. Bone augmentation on rabbit mandible was investigated by microcomputed tomography, sequential fluorescent labeling, and histologic examination 3 months after implantation. The result presents that all the scaffold groups maintain their augmented bone height after 3-month observation, whereas the autografting group presents an obvious bone resorption. Microcomputed tomography reveals that the graded porous group has significantly greater volume of new bone (P < 0.05) and similar bone density compared with the uniform pores groups. Bone substance distributes unevenly in all the 3 experimental groups. Greater bone volume can be observed in the area closer to the bone bed. The sequential fluorescent labeling observation reveals robust bone regeneration in the first month and faster bone growth in the graded porous scaffold group than that in the large porous scaffold group. Histologic examinations confirm bone structure in the aspect of distribution, activity, and maturity. We conclude that graded porous designed biodegradable beta-tricalcium phosphate scaffolds are beneficial to promote bone augmentation in the aspect of bone volume.

语种英语
所属项目编号7133255 ; R01DE021468 ; R01AR057837 ; W81XWH-10-1-0966
资助者Beijing Natural Science Foundation ; NIH ; DOD ; Beijing Natural Science Foundation ; NIH ; DOD
WOS记录号WOS:000350891600029
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52368
Collection北京大学口腔医学院_口腔修复科
作者单位1.Stanford Univ, Dept Orthoped Surg, Stanford, CA 94305 USA
2.Stanford Univ, Dept Mat Sci & Engn, Stanford, CA 94305 USA
3.Peking Univ, Dept Prosthodont, Sch & Hosp Stomatol, Beijing 100081, Peoples R China
Recommended Citation
GB/T 7714
Yang, Jingwen,Kang, Yunqing,Browne, Christopher,et al. Graded Porous beta-Tricalcium Phosphate Scaffolds Enhance Bone Regeneration in Mandible Augmentation[J]. JOURNAL OF CRANIOFACIAL SURGERY,2015,26(2):E148-E153.
APA Yang, Jingwen,Kang, Yunqing,Browne, Christopher,Jiang, Ting,&Yang, Yunzhi.(2015).Graded Porous beta-Tricalcium Phosphate Scaffolds Enhance Bone Regeneration in Mandible Augmentation.JOURNAL OF CRANIOFACIAL SURGERY,26(2),E148-E153.
MLA Yang, Jingwen,et al."Graded Porous beta-Tricalcium Phosphate Scaffolds Enhance Bone Regeneration in Mandible Augmentation".JOURNAL OF CRANIOFACIAL SURGERY 26.2(2015):E148-E153.
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