IR@PKUHSC  > 北京大学基础医学院  > 心血管所
学科主题基础医学
Preliminary investigation of sequence-independent DNA binding proteins in rat skeletal muscle sarcoplasmic reticulum and their function
Zhao, W1; Jiang, ZH1; Ni, JH1; Chen, KH1; Liu, NK1; Tang, J1; Jia, HT1; Tang, CS1
关键词Dna Binding Proteins Of Sr Ca2++ Uptake And Release ca2+-atpase Ryanodine Receptor
刊名SCIENCE IN CHINA SERIES C-LIFE SCIENCES
2000-04-01
43期:2页:209-216
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biology
研究领域[WOS]Life Sciences & Biomedicine - Other Topics
英文摘要

To observe the binding of plasmid DNA to cion-nuclear DNA binding proteins in sarcoplasmic reticulum (SR) and the effects of this binding on SR function, sarcoplasmic reticulum proteins in rat skeletal muscle were isolated by differential centrifuge and sucrose density-gradient centrifuge. The results showed that there are two sequence-independent DNA binding proteins in SR proteins, the molecular weights of which are 83 and 58 ku, respectively. Ca2+ uptake and release of SR were remarkably promoted by the binding of plasmid DNA to DNA binding proteins in SR, the mechanism is probably through increasing of Ca2+-ATPase activity in SR and changing of character of Ca2+ release channel ryanodine receptors induced by the binding. These results suggest that there exist DNA binding proteins in SR and its binding to DNA may affect Ca2+ transport of SR.

语种英语
WOS记录号WOS:000086744600012
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52369
专题北京大学基础医学院_心血管所
北京大学临床肿瘤学院_药剂科
作者单位1.Beijing Med Univ, Inst Cardiovasc Res, Beijing 100083, Peoples R China
2.Beijing Med Univ, Hosp 1, Inst Cardiovasc Res, Beijing 100034, Peoples R China
3.Beijing Med Univ, Dept Biochem & Mol Biol, Beijing 100083, Peoples R China
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GB/T 7714
Zhao, W,Jiang, ZH,Ni, JH,et al. Preliminary investigation of sequence-independent DNA binding proteins in rat skeletal muscle sarcoplasmic reticulum and their function[J]. SCIENCE IN CHINA SERIES C-LIFE SCIENCES,2000,43(2):209-216.
APA Zhao, W.,Jiang, ZH.,Ni, JH.,Chen, KH.,Liu, NK.,...&Tang, CS.(2000).Preliminary investigation of sequence-independent DNA binding proteins in rat skeletal muscle sarcoplasmic reticulum and their function.SCIENCE IN CHINA SERIES C-LIFE SCIENCES,43(2),209-216.
MLA Zhao, W,et al."Preliminary investigation of sequence-independent DNA binding proteins in rat skeletal muscle sarcoplasmic reticulum and their function".SCIENCE IN CHINA SERIES C-LIFE SCIENCES 43.2(2000):209-216.
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