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学科主题: 基础医学
题名:
Preliminary investigation of sequence-independent DNA binding proteins in rat skeletal muscle sarcoplasmic reticulum and their function
作者: Zhao, W1; Jiang, ZH1; Ni, JH1; Chen, KH1; Liu, NK1; Tang, J1; Jia, HT1; Tang, CS1
关键词: DNA binding proteins of SR ; Ca2+ uptake and release ; Ca2+-ATPase ; ryanodine receptor
刊名: SCIENCE IN CHINA SERIES C-LIFE SCIENCES
发表日期: 2000-04-01
卷: 43, 期:2, 页:209-216
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biology
研究领域[WOS]: Life Sciences & Biomedicine - Other Topics
英文摘要:

To observe the binding of plasmid DNA to cion-nuclear DNA binding proteins in sarcoplasmic reticulum (SR) and the effects of this binding on SR function, sarcoplasmic reticulum proteins in rat skeletal muscle were isolated by differential centrifuge and sucrose density-gradient centrifuge. The results showed that there are two sequence-independent DNA binding proteins in SR proteins, the molecular weights of which are 83 and 58 ku, respectively. Ca2+ uptake and release of SR were remarkably promoted by the binding of plasmid DNA to DNA binding proteins in SR, the mechanism is probably through increasing of Ca2+-ATPase activity in SR and changing of character of Ca2+ release channel ryanodine receptors induced by the binding. These results suggest that there exist DNA binding proteins in SR and its binding to DNA may affect Ca2+ transport of SR.

语种: 英语
WOS记录号: WOS:000086744600012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52369
Appears in Collections:基础医学院_心血管所_期刊论文

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作者单位: 1.Beijing Med Univ, Inst Cardiovasc Res, Beijing 100083, Peoples R China
2.Beijing Med Univ, Hosp 1, Inst Cardiovasc Res, Beijing 100034, Peoples R China
3.Beijing Med Univ, Dept Biochem & Mol Biol, Beijing 100083, Peoples R China

Recommended Citation:
Zhao, W,Jiang, ZH,Ni, JH,et al. Preliminary investigation of sequence-independent DNA binding proteins in rat skeletal muscle sarcoplasmic reticulum and their function[J]. SCIENCE IN CHINA SERIES C-LIFE SCIENCES,2000,43(2):209-216.
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