学科主题 | 基础医学 |
PTEN Interacts with Histone H1 and Controls Chromatin Condensation | |
Chen, Zhu Hong1,2; Zhu, Minglu1,2; Yang, Jingyi1; Liang, Hui1; He, Jinxue2; He, Shiming1; Wang, Pan1; Kang, Xi1,2; McNutt, Michael A.1; Yin, Yuxin1,2; Shen, Wen H.2 | |
刊名 | CELL REPORTS
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2014-09-25 | |
DOI | 10.1016/j.celrep.2014.08.008 |
卷 | 8期:6页:2003-2014 |
收录类别 | SCI |
文章类型 | Article |
WOS标题词 | Science & Technology |
类目[WOS] | Cell Biology |
资助者 | NIH ; China National Major Scientific Program (973 Project) ; National Natural Science Foundation of China ; Beijing Natural Science Foundation ; 111 Project ; Shu Fan Education and Research Foundation ; NIH ; China National Major Scientific Program (973 Project) ; National Natural Science Foundation of China ; Beijing Natural Science Foundation ; 111 Project ; Shu Fan Education and Research Foundation |
研究领域[WOS] | Cell Biology |
关键词[WOS] | TUMOR-SUPPRESSOR PTEN ; PROSTATE-CANCER ; ACETYLTRANSFERASE MOF ; H4-K16 ACETYLATION ; NUCLEAR PTEN ; CELLS ; TRANSCRIPTION ; GENE ; ACTIVATION ; PROTEINS |
英文摘要 | Chromatin organization and dynamics are integral to global gene transcription. Histone modification influences chromatin status and gene expression. PTEN plays multiple roles in tumor suppression, development, and metabolism. Here, we report on the interplay of PTEN, histone H1, and chromatin. We show that loss of PTEN leads to dissociation of histone H1 from chromatin and decondensation of chromatin. PTEN deletion also results in elevation of histone H4 acetylation at lysine 16, an epigenetic marker for chromatin activation. We found that PTEN and histone H1 physically interact through their C-terminal domains. Disruption of the PTEN C terminus promotes the chromatin association of MOF acetyltransferase and induces H4K16 acetylation. Hyperacetylation of H4K16 impairs the association of PTEN with histone H1, which constitutes regulatory feedback that may reduce chromatin stability. Our results demonstrate that PTEN controls chromatin condensation, thus influencing gene expression. We propose that PTEN regulates global gene transcription profiling through histones and chromatin remodeling. |
语种 | 英语 |
所属项目编号 | R01GM100478 ; R01CA133008 ; 2010CB912202 ; 30930021 ; 5100003 ; B07001 |
资助者 | NIH ; China National Major Scientific Program (973 Project) ; National Natural Science Foundation of China ; Beijing Natural Science Foundation ; 111 Project ; Shu Fan Education and Research Foundation ; NIH ; China National Major Scientific Program (973 Project) ; National Natural Science Foundation of China ; Beijing Natural Science Foundation ; 111 Project ; Shu Fan Education and Research Foundation |
WOS记录号 | WOS:000343867400036 |
Citation statistics | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.bjmu.edu.cn/handle/400002259/52371 |
Collection | 北京大学基础医学院_北京大学系统生物医学研究所 |
作者单位 | 1.Peking Univ, Beijing Key Lab Tumor Syst Biol, Peking Tsinghua Ctr Life Sci,Hlth Sci Ctr, Inst Syst Biomed,Dept Pathol,Sch Basic Med Sci, Beijing 100191, Peoples R China 2.Cornell Univ, Weill Med Coll, Dept Radiat Oncol, New York, NY 10065 USA |
Recommended Citation GB/T 7714 | Chen, Zhu Hong,Zhu, Minglu,Yang, Jingyi,et al. PTEN Interacts with Histone H1 and Controls Chromatin Condensation[J]. CELL REPORTS,2014,8(6):2003-2014. |
APA | Chen, Zhu Hong.,Zhu, Minglu.,Yang, Jingyi.,Liang, Hui.,He, Jinxue.,...&Shen, Wen H..(2014).PTEN Interacts with Histone H1 and Controls Chromatin Condensation.CELL REPORTS,8(6),2003-2014. |
MLA | Chen, Zhu Hong,et al."PTEN Interacts with Histone H1 and Controls Chromatin Condensation".CELL REPORTS 8.6(2014):2003-2014. |
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