学科主题基础医学
PTEN Interacts with Histone H1 and Controls Chromatin Condensation
Chen, Zhu Hong1,2; Zhu, Minglu1,2; Yang, Jingyi1; Liang, Hui1; He, Jinxue2; He, Shiming1; Wang, Pan1; Kang, Xi1,2; McNutt, Michael A.1; Yin, Yuxin1,2; Shen, Wen H.2
刊名CELL REPORTS
2014-09-25
DOI10.1016/j.celrep.2014.08.008
8期:6页:2003-2014
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology
研究领域[WOS]Cell Biology
关键词[WOS]TUMOR-SUPPRESSOR PTEN ; PROSTATE-CANCER ; ACETYLTRANSFERASE MOF ; H4-K16 ACETYLATION ; NUCLEAR PTEN ; CELLS ; TRANSCRIPTION ; GENE ; ACTIVATION ; PROTEINS
英文摘要

Chromatin organization and dynamics are integral to global gene transcription. Histone modification influences chromatin status and gene expression. PTEN plays multiple roles in tumor suppression, development, and metabolism. Here, we report on the interplay of PTEN, histone H1, and chromatin. We show that loss of PTEN leads to dissociation of histone H1 from chromatin and decondensation of chromatin. PTEN deletion also results in elevation of histone H4 acetylation at lysine 16, an epigenetic marker for chromatin activation. We found that PTEN and histone H1 physically interact through their C-terminal domains. Disruption of the PTEN C terminus promotes the chromatin association of MOF acetyltransferase and induces H4K16 acetylation. Hyperacetylation of H4K16 impairs the association of PTEN with histone H1, which constitutes regulatory feedback that may reduce chromatin stability. Our results demonstrate that PTEN controls chromatin condensation, thus influencing gene expression. We propose that PTEN regulates global gene transcription profiling through histones and chromatin remodeling.

语种英语
WOS记录号WOS:000343867400036
项目编号R01GM100478 ; R01CA133008 ; 2010CB912202 ; 30930021 ; 5100003 ; B07001
资助机构NIH ; China National Major Scientific Program (973 Project) ; National Natural Science Foundation of China ; Beijing Natural Science Foundation ; 111 Project ; Shu Fan Education and Research Foundation
引用统计
被引频次:29[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52371
专题北京大学基础医学院_北京大学系统生物医学研究所
北京大学基础医学院
作者单位1.Peking Univ, Beijing Key Lab Tumor Syst Biol, Peking Tsinghua Ctr Life Sci,Hlth Sci Ctr, Inst Syst Biomed,Dept Pathol,Sch Basic Med Sci, Beijing 100191, Peoples R China
2.Cornell Univ, Weill Med Coll, Dept Radiat Oncol, New York, NY 10065 USA
推荐引用方式
GB/T 7714
Chen, Zhu Hong,Zhu, Minglu,Yang, Jingyi,et al. PTEN Interacts with Histone H1 and Controls Chromatin Condensation[J]. CELL REPORTS,2014,8(6):2003-2014.
APA Chen, Zhu Hong.,Zhu, Minglu.,Yang, Jingyi.,Liang, Hui.,He, Jinxue.,...&Shen, Wen H..(2014).PTEN Interacts with Histone H1 and Controls Chromatin Condensation.CELL REPORTS,8(6),2003-2014.
MLA Chen, Zhu Hong,et al."PTEN Interacts with Histone H1 and Controls Chromatin Condensation".CELL REPORTS 8.6(2014):2003-2014.
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