IR@PKUHSC  > 北京大学第一临床医学院  > 放射治疗科
学科主题临床医学
The association of lesion eccentricity with plaque morphology and components in the superficial femoral artery: a high-spatial-resolution, multi-contrast weighted CMR study
Li, Feiyu1,2; McDermott, Mary McGrae3; Li, Debiao4; Carroll, Timothy J.4; Hippe, Daniel S.1; Kramer, Christopher M.5,6; Fan, Zhaoyang4; Zhao, Xihai1; Hatsukami, Thomas S.7; Chu, Baocheng1; Wang, Jinnan8; Yuan, Chun1
刊名JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
2010-07-01
DOI10.1186/1532-429X-12-37
12
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cardiac & Cardiovascular Systems ; Radiology, Nuclear Medicine & Medical Imaging
资助者National Heart Lung and Blood Institute ; National Heart Lung and Blood Institute
研究领域[WOS]Cardiovascular System & Cardiology ; Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]MAGNETIC-RESONANCE ; CEREBROVASCULAR EVENTS ; DISEASE ; CALCIFICATION ; MRI ; MECHANISMS ; MORTALITY ; ANGINA
英文摘要

Background: Atherosclerotic plaque morphology and components are predictors of subsequent cardiovascular events. However, associations of plaque eccentricity with plaque morphology and plaque composition are unclear. This study investigated associations of plaque eccentricity with plaque components and morphology in the proximal superficial femoral artery using cardiovascular magnetic resonance (CMR).

Methods: Twenty-eight subjects with an ankle-brachial index less than 1.00 were examined with 1.5T high-spatial-resolution, multi-contrast weighted CMR. One hundred and eighty diseased locations of the proximal superficial femoral artery (about 40 mm) were analyzed. The eccentric lesion was defined as [(Maximum wall thickness-Minimum wall thickness)/Maximum wall thickness] >= 0.5. The arterial morphology and plaque components were measured using semi-automatic image analysis software.

Results: One hundred and fifteen locations were identified as eccentric lesions and sixty-five as concentric lesions. The eccentric lesions had larger wall but similar lumen areas, larger mean and maximum wall thicknesses, and more calcification and lipid rich necrotic core, compared to concentric lesions. For lesions with the same lumen area, the degree of eccentricity was associated with an increased wall area. Eccentricity (dichotomous as eccentric or concentric) was independently correlated with the prevalence of calcification (odds ratio 3.78, 95% CI 1.47-9.70) after adjustment for atherosclerotic risk factors and wall area.

Conclusions: Plaque eccentricity is associated with preserved lumen size and advanced plaque features such as larger plaque burden, more lipid content, and increased calcification in the superficial femoral artery.

语种英语
所属项目编号R01-HL083064
资助者National Heart Lung and Blood Institute ; National Heart Lung and Blood Institute
WOS记录号WOS:000280093000001
引用统计
被引频次:25[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52372
专题北京大学第一临床医学院_放射治疗科
作者单位1.Univ Virginia, Dept Radiol, Charlottesville, VA USA
2.Univ Virginia, Dept Med, Charlottesville, VA USA
3.Univ Washington, Dept Radiol, Seattle, WA 98195 USA
4.Peking Univ, Hosp 1, Dept Radiol, Beijing 100871, Peoples R China
5.Northwestern Univ, Dept Med, Feinberg Sch Med, Chicago, IL 60611 USA
6.Northwestern Univ, Dept Radiol, Feinberg Sch Med, Chicago, IL 60611 USA
7.Univ Washington, Dept Surg, Seattle, WA 98195 USA
8.Philips Res N Amer, Clin Sites Res Program, Briarcliff Manor, NY USA
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Li, Feiyu,McDermott, Mary McGrae,Li, Debiao,et al. The association of lesion eccentricity with plaque morphology and components in the superficial femoral artery: a high-spatial-resolution, multi-contrast weighted CMR study[J]. JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE,2010,12.
APA Li, Feiyu.,McDermott, Mary McGrae.,Li, Debiao.,Carroll, Timothy J..,Hippe, Daniel S..,...&Yuan, Chun.(2010).The association of lesion eccentricity with plaque morphology and components in the superficial femoral artery: a high-spatial-resolution, multi-contrast weighted CMR study.JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE,12.
MLA Li, Feiyu,et al."The association of lesion eccentricity with plaque morphology and components in the superficial femoral artery: a high-spatial-resolution, multi-contrast weighted CMR study".JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE 12(2010).
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