IR@PKUHSC  > 北京大学第三临床医学院  > 肿瘤放疗科
学科主题临床医学
A Novel Conformal Arc Technique for Postoperative Whole Pelvic Radiotherapy for Endometrial Cancer
Yan, Ruijie; Jiang, Weijuan; Wang, Junjie
关键词Endometrial Cancer Conformal Arc Therapy Whole Pelvic Radiotherapy Intensity-modulated Radiation Therapy 3-dimensional Conformal Radiotherapy
刊名INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
2009-12-01
DOI10.1111/IGC.0b013e3181bd35a6
19期:9页:1574-1579
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Obstetrics & Gynecology
研究领域[WOS]Oncology ; Obstetrics & Gynecology
关键词[WOS]INTENSITY-MODULATED RADIOTHERAPY ; ACUTE HEMATOLOGIC TOXICITY ; RADIATION-THERAPY ; GYNECOLOGIC MALIGNANCIES ; ADJUVANT TREATMENT ; CERVICAL-CANCER ; CARCINOMA ; SURGERY ; TRIAL ; RISK
英文摘要

Introduction: Conventional whole pelvic radiotherapy (WPRT) with 3-dimensional conformal radiotherapy (3D-CRT) exposes most of the contents of the true pelvis to the prescribed dose. Intensity-modulated radiation therapy (IMRT) provides more conformal dose distribution and better sparing of critical structures for WPRT. However, IMRT is more complicated in planning and delivery, requiring more expensive equipment and time-consuming quality assurance. We explore and evaluate a novel conformal arc radio-therapeutic technique for postoperative WPRT for endometrial cancer in this study.

Methods: This technique involves 2-axis conformal arc therapy (2A-CAT) with 180-degree rotation around 2 isocenters each in 2 separate dose-shaping structures. Dosimetric comparison with 3D-CRT and IMRT for 10 endometrial cancer patients undergoing postoperative WPRT was performed to evaluate this new 2A-CAT technique.

Results: The mean conformity indices were 0.83, 0.61, and 0.88 for 2A-CAT, 3D-CRT, and IMRT, respectively. The mean homogeneity indices were 1.15, 1.08, and 1.10. The mean doses to bowel, rectum, bladder, and pelvic bone marrow were, respectively, 1.19, 3.39, 4.65, and 1.64 Gy lower with 2A-CAT than with 3D-CRT (P < 0.05), whereas a little higher than with IMRT The mean dose to normal tissue was 1.87 Gy higher with 2A-CAT than with IMRT (P = 0.00).

Conclusions: In postoperative WPRT for endometrial cancer, 2A-CAT significantly improves the dose conformity and sparing of bowel, rectum, and bladder compared with 3D-CRT. Despite dose uniformity and conformity being still inferior to those of IMRT, its simplicity and extensive availability combined with further improvement warrant it as a potential shortcut alternative to IMRT.

语种英语
WOS记录号WOS:000272898400022
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52373
专题北京大学第三临床医学院_肿瘤放疗科
作者单位Peking Univ, Ctr Canc, Hosp 3, Dept Radiat Oncol, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Yan, Ruijie,Jiang, Weijuan,Wang, Junjie. A Novel Conformal Arc Technique for Postoperative Whole Pelvic Radiotherapy for Endometrial Cancer[J]. INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER,2009,19(9):1574-1579.
APA Yan, Ruijie,Jiang, Weijuan,&Wang, Junjie.(2009).A Novel Conformal Arc Technique for Postoperative Whole Pelvic Radiotherapy for Endometrial Cancer.INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER,19(9),1574-1579.
MLA Yan, Ruijie,et al."A Novel Conformal Arc Technique for Postoperative Whole Pelvic Radiotherapy for Endometrial Cancer".INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER 19.9(2009):1574-1579.
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