IR@PKUHSC  > 北京大学第一临床医学院  > 儿科
学科主题临床医学
Effects of endogenous sulfur dioxide on monocrotaline-induced pulmonary hypertension in rats
Jin, Hong-fang1; Du, Shu-xu1; Zhao, Xia1; Wei, Hong-ling1; Wang, Yan-fei1; Liang, Yin-fang1; Tang, Chao-shu2,3; Du, Jun-bao1,3
关键词Monocrotaline Pulmonary Hypertension Sulfur Dioxide
刊名ACTA PHARMACOLOGICA SINICA
2008-10-01
DOI10.1111/j.1745-7254.2008.00864.x
29期:10页:1157-1166
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]Chemistry ; Pharmacology & Pharmacy
关键词[WOS]SUPEROXIDE-DISMUTASE ; LIPID-PEROXIDATION ; ENDOTHELIAL-CELLS ; OXIDATIVE STRESS ; HYDROGEN-SULFIDE ; SERUM SULFITE ; MICE ; ANTIOXIDANT ; INHALATION ; ARTERY
英文摘要

Aim: The present study aimed to explore the protective effect of endogenous sulfur dioxide (SO2) in the development of monocrotaline (MCT)-induced pulmonary hypertension (PH) in rats. Methods: Forty Wistar rats were randomly divided into the MCT group receiving MCT treatment, the MCT+L-aspartate-beta-hydroxamate (HDX) group receiving MCT plus HDX treatment, the MCT+SO2 group receiving MCT plus SO2 donor treatment, and the control group. Mean pulmonary artery pressure (mPAP) and structural changes in pulmonary arteries were evaluated. SO2 content, aspartate aminotransferase activity, and gene expression were measured. Superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT), reduced glutathione (GSH), oxidized glutathione, and malondialdehyde (MDA) levels were assayed. Results: In the MCT-treated rats, mPAP and right ventricle/(left ventricle+septum) increased significantly (P < 0.01), pulmonary vascular structural remodeling developed, and SOD, GSH-Px, CAT, GSH, and MDA levels of lung homogenates significantly increased (P < 0.01) in association with the elevated SO2 content, aspartate aminotransferase activity, and gene expression, compared with the control rats. In the MCT+HDX-treated rats, lung tissues and plasma SO2 content and aspartate aminotransferase activities decreased significantly, whereas the mPAP and pulmonary vascular structural remodeling were markedly aggravated with the decreased SOD, CAT, and GSH levels of lung tissue homogenates compared with the MCT-treated rats (P < 0.01). In contrast, with the use of a SO2 donor, the pulmonary vascular structural remodeling was obviously lessened with elevated lung tissue SOD, GSH-Px, and MDA content, and plasma SOD, GSH-Px, and CAT levels. Conclusion: Endogenous SO2 might play a protective role in the pathogenesis of MCT-induced PH and promote endogenous antioxidative capacities.

语种英语
WOS记录号WOS:000259937500003
项目编号2006CB503807 ; 30630031 ; 7072082 ; 7082095 ; 20070001702 ; 985-2-087-111
资助机构Major Basic Research Program of China ; National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Research Fund for the Doctoral Program of Ministry of Education of China ; Cheung Kong Scholars Program
引用统计
被引频次:53[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52375
专题北京大学第一临床医学院_儿科
北京大学第三临床医学院_儿科
作者单位1.Peking Univ, Hosp 1, Dept Pediat, Beijing 100034, Peoples R China
2.Peking Univ, Hosp 1, Inst Cardiovasc Res, Beijing 100034, Peoples R China
3.Minist Educ Res, Key Lab Mol Cardiovasc Dis, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Jin, Hong-fang,Du, Shu-xu,Zhao, Xia,et al. Effects of endogenous sulfur dioxide on monocrotaline-induced pulmonary hypertension in rats[J]. ACTA PHARMACOLOGICA SINICA,2008,29(10):1157-1166.
APA Jin, Hong-fang.,Du, Shu-xu.,Zhao, Xia.,Wei, Hong-ling.,Wang, Yan-fei.,...&Du, Jun-bao.(2008).Effects of endogenous sulfur dioxide on monocrotaline-induced pulmonary hypertension in rats.ACTA PHARMACOLOGICA SINICA,29(10),1157-1166.
MLA Jin, Hong-fang,et al."Effects of endogenous sulfur dioxide on monocrotaline-induced pulmonary hypertension in rats".ACTA PHARMACOLOGICA SINICA 29.10(2008):1157-1166.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Jin, Hong-fang]的文章
[Du, Shu-xu]的文章
[Zhao, Xia]的文章
百度学术
百度学术中相似的文章
[Jin, Hong-fang]的文章
[Du, Shu-xu]的文章
[Zhao, Xia]的文章
必应学术
必应学术中相似的文章
[Jin, Hong-fang]的文章
[Du, Shu-xu]的文章
[Zhao, Xia]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。