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学科主题: 药学
题名:
Preparation, characterization and biodistribution of nanostructured lipid carriers for parenteral delivery of bifendate
作者: Feng, Feifei1,2; Zheng, Dandan1; Zhang, Dianrui1; Duan, Cunxian1; Wang, Yancai1; Jia, Lejiao1; Wang, Feihu1; Liu, Yue1; Gao, Qun1; Zhang, Qiang3
关键词: nanostructured lipid carriers (NLC) ; bifendate (DDB) ; entrapment efficiency ; biodistribution ; liver targeting
刊名: JOURNAL OF MICROENCAPSULATION
发表日期: 2011
DOI: 10.3109/02652048.2011.559285
卷: 28, 期:4, 页:280-285
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Applied ; Engineering, Chemical ; Pharmacology & Pharmacy
研究领域[WOS]: Chemistry ; Engineering ; Pharmacology & Pharmacy
关键词[WOS]: TRANS-RETINOIC ACID ; PHYSICOCHEMICAL CHARACTERIZATION ; TISSUE DISTRIBUTION ; NANOPARTICLES SLN ; TOPICAL DELIVERY ; DERMAL PRODUCTS ; NLC ; RELEASE ; PHARMACOKINETICS ; BIOAVAILABILITY
英文摘要:

Nanostructured lipid carrier (NLC)-loaded bifendate (DDB) was prepared by melt-emulsification method to improve drug payloads and liver targeting. The particle size of the prepared formulation analysed by photon correlation spectroscopy (PCS) was 217.4 nm with a narrow polydispersity index (PI) lower than 0.2, meanwhile the loading capacity increased from 4.3%% to 15.7%% in comparison with DDB-loaded SLN reported in previous study. The zeta potential value was --21.91 mV, and transmission electron microscopy studies revealed NLC of irregularly spherical shape. With respect to lipid polymorphism, a less ordered structure of NLC was confirmed by differential scanning calorimetry (DSC) and X-ray diffraction (XRD). In addition, tissue distribution of DDB-loaded NLC and DDB solution were carried out in Kunming strain mice. In tested organs, the distribution of DDB-loaded NLC to liver was higher than that of free drug. These results support the potential applications of NLC for the delivery of DDB.

语种: 英语
所属项目编号: 2009CB930300
项目资助者: National Basic Research Programme of China
WOS记录号: WOS:000290316200006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52376
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Shandong Univ, Coll Pharm, Dept Pharmaceut, Jinan 250012, Shandong, Peoples R China
2.Shanghai Seventh Peoples Hosp, Dept Pharm, Shanghai 200137, Peoples R China
3.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China

Recommended Citation:
Feng, Feifei,Zheng, Dandan,Zhang, Dianrui,et al. Preparation, characterization and biodistribution of nanostructured lipid carriers for parenteral delivery of bifendate[J]. JOURNAL OF MICROENCAPSULATION,2011,28(4):280-285.
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