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Preparation, characterization and biodistribution of nanostructured lipid carriers for parenteral delivery of bifendate
Feng, Feifei1,2; Zheng, Dandan1; Zhang, Dianrui1; Duan, Cunxian1; Wang, Yancai1; Jia, Lejiao1; Wang, Feihu1; Liu, Yue1; Gao, Qun1; Zhang, Qiang3
关键词Nanostructured Lipid Carriers (Nlc) Bifendate (Ddb) Entrapment Efficiency Biodistribution Liver Targeting
刊名JOURNAL OF MICROENCAPSULATION
2011
DOI10.3109/02652048.2011.559285
28期:4页:280-285
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Applied ; Engineering, Chemical ; Pharmacology & Pharmacy
资助者National Basic Research Programme of China ; National Basic Research Programme of China
研究领域[WOS]Chemistry ; Engineering ; Pharmacology & Pharmacy
关键词[WOS]TRANS-RETINOIC ACID ; PHYSICOCHEMICAL CHARACTERIZATION ; TISSUE DISTRIBUTION ; NANOPARTICLES SLN ; TOPICAL DELIVERY ; DERMAL PRODUCTS ; NLC ; RELEASE ; PHARMACOKINETICS ; BIOAVAILABILITY
英文摘要

Nanostructured lipid carrier (NLC)-loaded bifendate (DDB) was prepared by melt-emulsification method to improve drug payloads and liver targeting. The particle size of the prepared formulation analysed by photon correlation spectroscopy (PCS) was 217.4 nm with a narrow polydispersity index (PI) lower than 0.2, meanwhile the loading capacity increased from 4.3%% to 15.7%% in comparison with DDB-loaded SLN reported in previous study. The zeta potential value was --21.91 mV, and transmission electron microscopy studies revealed NLC of irregularly spherical shape. With respect to lipid polymorphism, a less ordered structure of NLC was confirmed by differential scanning calorimetry (DSC) and X-ray diffraction (XRD). In addition, tissue distribution of DDB-loaded NLC and DDB solution were carried out in Kunming strain mice. In tested organs, the distribution of DDB-loaded NLC to liver was higher than that of free drug. These results support the potential applications of NLC for the delivery of DDB.

语种英语
所属项目编号2009CB930300
资助者National Basic Research Programme of China ; National Basic Research Programme of China
WOS记录号WOS:000290316200006
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52376
专题北京大学药学院
作者单位1.Shandong Univ, Coll Pharm, Dept Pharmaceut, Jinan 250012, Shandong, Peoples R China
2.Shanghai Seventh Peoples Hosp, Dept Pharm, Shanghai 200137, Peoples R China
3.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
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GB/T 7714
Feng, Feifei,Zheng, Dandan,Zhang, Dianrui,et al. Preparation, characterization and biodistribution of nanostructured lipid carriers for parenteral delivery of bifendate[J]. JOURNAL OF MICROENCAPSULATION,2011,28(4):280-285.
APA Feng, Feifei.,Zheng, Dandan.,Zhang, Dianrui.,Duan, Cunxian.,Wang, Yancai.,...&Zhang, Qiang.(2011).Preparation, characterization and biodistribution of nanostructured lipid carriers for parenteral delivery of bifendate.JOURNAL OF MICROENCAPSULATION,28(4),280-285.
MLA Feng, Feifei,et al."Preparation, characterization and biodistribution of nanostructured lipid carriers for parenteral delivery of bifendate".JOURNAL OF MICROENCAPSULATION 28.4(2011):280-285.
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