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Preparation, characterization and biodistribution of nanostructured lipid carriers for parenteral delivery of bifendate
Feng, Feifei1,2; Zheng, Dandan1; Zhang, Dianrui1; Duan, Cunxian1; Wang, Yancai1; Jia, Lejiao1; Wang, Feihu1; Liu, Yue1; Gao, Qun1; Zhang, Qiang3
关键词Nanostructured Lipid Carriers (Nlc) Bifendate (Ddb) Entrapment Efficiency Biodistribution Liver Targeting
刊名JOURNAL OF MICROENCAPSULATION
2011
DOI10.3109/02652048.2011.559285
28期:4页:280-285
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Applied ; Engineering, Chemical ; Pharmacology & Pharmacy
研究领域[WOS]Chemistry ; Engineering ; Pharmacology & Pharmacy
关键词[WOS]TRANS-RETINOIC ACID ; PHYSICOCHEMICAL CHARACTERIZATION ; TISSUE DISTRIBUTION ; NANOPARTICLES SLN ; TOPICAL DELIVERY ; DERMAL PRODUCTS ; NLC ; RELEASE ; PHARMACOKINETICS ; BIOAVAILABILITY
英文摘要

Nanostructured lipid carrier (NLC)-loaded bifendate (DDB) was prepared by melt-emulsification method to improve drug payloads and liver targeting. The particle size of the prepared formulation analysed by photon correlation spectroscopy (PCS) was 217.4 nm with a narrow polydispersity index (PI) lower than 0.2, meanwhile the loading capacity increased from 4.3%% to 15.7%% in comparison with DDB-loaded SLN reported in previous study. The zeta potential value was --21.91 mV, and transmission electron microscopy studies revealed NLC of irregularly spherical shape. With respect to lipid polymorphism, a less ordered structure of NLC was confirmed by differential scanning calorimetry (DSC) and X-ray diffraction (XRD). In addition, tissue distribution of DDB-loaded NLC and DDB solution were carried out in Kunming strain mice. In tested organs, the distribution of DDB-loaded NLC to liver was higher than that of free drug. These results support the potential applications of NLC for the delivery of DDB.

语种英语
WOS记录号WOS:000290316200006
项目编号2009CB930300
资助机构National Basic Research Programme of China
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52376
专题北京大学药学院
北京大学药学院_药剂学系
作者单位1.Shandong Univ, Coll Pharm, Dept Pharmaceut, Jinan 250012, Shandong, Peoples R China
2.Shanghai Seventh Peoples Hosp, Dept Pharm, Shanghai 200137, Peoples R China
3.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
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GB/T 7714
Feng, Feifei,Zheng, Dandan,Zhang, Dianrui,et al. Preparation, characterization and biodistribution of nanostructured lipid carriers for parenteral delivery of bifendate[J]. JOURNAL OF MICROENCAPSULATION,2011,28(4):280-285.
APA Feng, Feifei.,Zheng, Dandan.,Zhang, Dianrui.,Duan, Cunxian.,Wang, Yancai.,...&Zhang, Qiang.(2011).Preparation, characterization and biodistribution of nanostructured lipid carriers for parenteral delivery of bifendate.JOURNAL OF MICROENCAPSULATION,28(4),280-285.
MLA Feng, Feifei,et al."Preparation, characterization and biodistribution of nanostructured lipid carriers for parenteral delivery of bifendate".JOURNAL OF MICROENCAPSULATION 28.4(2011):280-285.
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