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Structure elucidation and immunological activity of a novel polysaccharide from the fruit bodies of an edible mushroom, Sarcodon aspratus (Berk.) S. Ito.
Han, Xiao-Qiang1; Chai, Xing-Yun1,2; Jia, Ya-Min1; Han, Chun-Xia3; Tu, Peng-Fei1
关键词Sarcodon AS.ratuS.(Berk.) S. Ito. Edible Mushroom Polysaccharide Glucan Immunological Activity
刊名INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
2010-10-01
DOI10.1016/j.ijbiomac.2010.05.021
47期:3页:420-424
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology
资助者Analytical and Testing Center ; Analytical and Testing Center
研究领域[WOS]Biochemistry & Molecular Biology
关键词[WOS]PLEUROTUS-OSTREATUS ; ALDITOL ACETATES ; MYCELIA ; SUGARS ; BODY ; GLC
英文摘要

A water-soluble polysaccharide with a molar weight of 4.3 x 10(5) Da, termed as HBP was isolated from the fruit bodies of an edible mushroom, Sarcodon aspratus (Berk.) S. Ito. Composition, methylation analysis, Fourier transform infrared spectroscopy, and nuclear magnetic resonance spectroscopy experiments were conducted to elucidate its structure. The results indicated that HBP is a glucan featuring a backbone of (1 -> 6)-linked-beta-D-glucopyranosyl residues, which occasionally branched at O-3 position on along the backbone and substituted by the side chains that consisting of (1 -> 3)-linked-beta-D-glucopyranosyl, (1 -> 4)-linked-beta-D-glucopyranosyl and non-reducing end beta-D-glucopyranosyl residues. Immunological activity evaluation by H(3)-thymidine incorporation method revealed that HBP can significantly stimulate the proliferation of the cultured mice spleen lymphocyte in a dose-dependent manner, thus, HBP is a promising potential immunomodulator that can be used as healthcare food or medicine against pathogens and tumors. (C) 2010 Elsevier B.V. All rights reserved.

语种英语
资助者Analytical and Testing Center ; Analytical and Testing Center
WOS记录号WOS:000281490500016
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52383
专题北京大学药学院
作者单位1.Dionex China Ltd, Applicat Ctr, Beijing 100085, Peoples R China
2.Peking Univ, Hlth Sci Ctr, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
3.Chinese Acad Sci, Key Lab Marine Bioresources Sustainable Utilizat, S China Sea Inst Oceanol, Guangzhou 510301, Guangdong, Peoples R China
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Han, Xiao-Qiang,Chai, Xing-Yun,Jia, Ya-Min,et al. Structure elucidation and immunological activity of a novel polysaccharide from the fruit bodies of an edible mushroom, Sarcodon aspratus (Berk.) S. Ito.[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2010,47(3):420-424.
APA Han, Xiao-Qiang,Chai, Xing-Yun,Jia, Ya-Min,Han, Chun-Xia,&Tu, Peng-Fei.(2010).Structure elucidation and immunological activity of a novel polysaccharide from the fruit bodies of an edible mushroom, Sarcodon aspratus (Berk.) S. Ito..INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,47(3),420-424.
MLA Han, Xiao-Qiang,et al."Structure elucidation and immunological activity of a novel polysaccharide from the fruit bodies of an edible mushroom, Sarcodon aspratus (Berk.) S. Ito.".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 47.3(2010):420-424.
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