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学科主题: 临床医学
题名:
Integrin beta 3 and its ligand regulate the expression of uPA through p38 MAPK in breast cancer
作者: Wang, Rui2,3; Li, Zhao-Qing4; Han, Xu5; Li, Bai-Lin6; Mi, Xiao-Yi2,3; Sun, Li-Mei2,3; Song, Min1,2,3; Han, Yan-Chun2,3; Zhao, Yan2,3; Wang, En-Hua2,3
关键词: integrin ; TN ; breast cancer ; p38
刊名: APMIS
发表日期: 2010-12-01
DOI: 10.1111/j.1600-0463.2010.02687.x
卷: 118, 期:12, 页:909-917
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Immunology ; Microbiology ; Pathology
研究领域[WOS]: Immunology ; Microbiology ; Pathology
关键词[WOS]: UROKINASE PLASMINOGEN-ACTIVATOR ; TENASCIN-C EXPRESSION ; IN-VITRO ; EXTRACELLULAR-MATRIX ; CELL-ADHESION ; PROGNOSTIC-SIGNIFICANCE ; SIGNALING PATHWAYS ; COLORECTAL-CANCER ; ENDOTHELIAL-CELLS ; EPITHELIAL-CELLS
英文摘要:

Interplay between integrins and extracellular matrix is suggested to play an important role in malignant progression and tumor differentiation. The aim of the study was to determine the combined expression of integrin beta 3 and tenascin-c (TN-c) in breast cancer and examine whether integrin beta 3 and TN-c can activate urokinase-type plasminogen activator (uPA) through p38 mitogen-activated protein kinase (p38 MAPK). We detected the expression of integrin beta 3, TN-c, p-p38, and uPA in 80 cases of breast invasive ductal carcinoma by immunohistochemistry. In addition, we blocked integrin beta 3 and TN-c in the MDA-MB-231 breast cancer cells and detected the expression of p-p38 and uPA by Western blot. Integrin beta 3, TN-c, p-p38, and uPA showed high levels of expression in breast invasive ductal carcinoma. The expression of integrin beta 3, TN-c, and uPA was correlated with lymph node metastasis and TNM stage in breast cancer. Furthermore, correlations were noted between any two of the three proteins. The expression of p-p38 and uPA decreased in MDA-MB-231 cells after the addition of integrin beta 3 antibody and TN-c antibody. The expression of uPA decreased after addition of SB203580. Our results demonstrate that inhibition of the expression of integrin beta 3 and TN-c could decrease the expression of uPA through p38 MAPK in breast cancer, suggesting that the interaction between integrin beta 3 and TN-c serves an important role in breast cancer.

语种: 英语
WOS记录号: WOS:000284317500001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52384
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.China Med Univ, Dept Pathol, Coll Basic Med Sci, Shenyang 110001, Liaoning, Peoples R China
2.China Med Univ, Dept Pathol, Affiliated Hosp 1, Shenyang 110001, Liaoning, Peoples R China
3.China Med Univ, Inst Pathol & Pathophysol, Shenyang 110001, Liaoning, Peoples R China
4.Peking Univ, Peoples Hosp, Beijing 100871, Peoples R China
5.China Med Univ, Dept Chest Surg, Affiliated Hosp 4, Shenyang 110001, Liaoning, Peoples R China
6.China Med Univ, Dept Chem, Coll Basic Med Sci, Shenyang 110001, Liaoning, Peoples R China

Recommended Citation:
Wang, Rui,Li, Zhao-Qing,Han, Xu,et al. Integrin beta 3 and its ligand regulate the expression of uPA through p38 MAPK in breast cancer[J]. APMIS,2010,118(12):909-917.
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