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Antagonism activity against acute myocardial ischemia of Paeoniflorin and its pharmacokinetic/pharmacodynamic (PK/PD) modeling in rats
Chen, Wenqian1,2; Zhang, Yanqing1,2,3; Xie, Junbo3; Zhou, Tianyan1,2; Lu, Wei1,2
关键词Paeoniflorin Acute Myocardial Ischemia Anticoagulant Activity Pharmacokinetics Pharmacodynamics
刊名JOURNAL OF MEDICINAL PLANTS RESEARCH
2011-12-09
DOI10.5897/JMPR11.400
5期:29页:6496-6501
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal
研究领域[WOS]Pharmacology & Pharmacy
英文摘要

The aim of the present work was to investigate the effects of paeoniflorin (PF) on acute myocardial ischemia in rats. Meanwhile, after intravenous and oral administration of PF, the pharmacokinetic and pharmacodynamic characters of PF in rats were also studied. Plasma concentration of paeoniflorin was determined using a simple and rapid HPLC method. Nonlinear mixed-effect modeling (NONMEM) method was used for pharmacokinetic (PK) and pharmacodynamic (PD) analysis. A two-compartment model with first-order degradation in the absorption compartment was employed for the PK data analysis. The results showed that PF exhibited significant antagonism against acute myocardial ischemia and a PK/PD link model and two IDR models were developed and compared for anticoagulant activity of PF. It was concluded that the integrated PK/PD model could well characterize PK and PD behaviors of PF in rats.

语种英语
WOS记录号WOS:000299572400004
项目编号30472165 ; 26870507728
资助机构National Natural Science Foundation ; State Key Laboratory of Natural and Biomimetic Drugs
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52386
专题北京大学药学院_药剂学系
作者单位1.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Beijing 100191, Peoples R China
3.Tianjin Univ Commerce, Dept Pharmaceut Engn, Tianjin 300134, Peoples R China
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GB/T 7714
Chen, Wenqian,Zhang, Yanqing,Xie, Junbo,et al. Antagonism activity against acute myocardial ischemia of Paeoniflorin and its pharmacokinetic/pharmacodynamic (PK/PD) modeling in rats[J]. JOURNAL OF MEDICINAL PLANTS RESEARCH,2011,5(29):6496-6501.
APA Chen, Wenqian,Zhang, Yanqing,Xie, Junbo,Zhou, Tianyan,&Lu, Wei.(2011).Antagonism activity against acute myocardial ischemia of Paeoniflorin and its pharmacokinetic/pharmacodynamic (PK/PD) modeling in rats.JOURNAL OF MEDICINAL PLANTS RESEARCH,5(29),6496-6501.
MLA Chen, Wenqian,et al."Antagonism activity against acute myocardial ischemia of Paeoniflorin and its pharmacokinetic/pharmacodynamic (PK/PD) modeling in rats".JOURNAL OF MEDICINAL PLANTS RESEARCH 5.29(2011):6496-6501.
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