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学科主题: 药学
题名:
Antagonism activity against acute myocardial ischemia of Paeoniflorin and its pharmacokinetic/pharmacodynamic (PK/PD) modeling in rats
作者: Chen, Wenqian1,2; Zhang, Yanqing1,2,3; Xie, Junbo3; Zhou, Tianyan1,2; Lu, Wei1,2
关键词: Paeoniflorin ; acute myocardial ischemia ; anticoagulant activity ; pharmacokinetics ; pharmacodynamics
刊名: JOURNAL OF MEDICINAL PLANTS RESEARCH
发表日期: 2011-12-09
DOI: 10.5897/JMPR11.400
卷: 5, 期:29, 页:6496-6501
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Medicinal
研究领域[WOS]: Pharmacology & Pharmacy
英文摘要:

The aim of the present work was to investigate the effects of paeoniflorin (PF) on acute myocardial ischemia in rats. Meanwhile, after intravenous and oral administration of PF, the pharmacokinetic and pharmacodynamic characters of PF in rats were also studied. Plasma concentration of paeoniflorin was determined using a simple and rapid HPLC method. Nonlinear mixed-effect modeling (NONMEM) method was used for pharmacokinetic (PK) and pharmacodynamic (PD) analysis. A two-compartment model with first-order degradation in the absorption compartment was employed for the PK data analysis. The results showed that PF exhibited significant antagonism against acute myocardial ischemia and a PK/PD link model and two IDR models were developed and compared for anticoagulant activity of PF. It was concluded that the integrated PK/PD model could well characterize PK and PD behaviors of PF in rats.

语种: 英语
所属项目编号: 30472165 ; 26870507728
项目资助者: National Natural Science Foundation ; State Key Laboratory of Natural and Biomimetic Drugs
WOS记录号: WOS:000299572400004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52386
Appears in Collections:北京大学药学院_药剂学系_期刊论文

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作者单位: 1.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Beijing 100191, Peoples R China
3.Tianjin Univ Commerce, Dept Pharmaceut Engn, Tianjin 300134, Peoples R China

Recommended Citation:
Chen, Wenqian,Zhang, Yanqing,Xie, Junbo,et al. Antagonism activity against acute myocardial ischemia of Paeoniflorin and its pharmacokinetic/pharmacodynamic (PK/PD) modeling in rats[J]. JOURNAL OF MEDICINAL PLANTS RESEARCH,2011,5(29):6496-6501.
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