北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学药学院  > 期刊论文
学科主题: 药学
题名:
Synthesis and in vitro antitumor activity of 4(3H)-quinazolinone derivatives with dithiocarbamate side chains
作者: Cao, SL1; Feng, YP1; Jiang, YY1; Liu, SY1; Ding, GY1; Li, RT1
关键词: 4(3H)-quinazolinone ; dithiocarbamate ; antitumor activity ; K562 cells
刊名: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
发表日期: 2005-04-01
DOI: 10.1016/j.bmcl.2005.01.083
卷: 15, 期:7, 页:1915-1917
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Medicinal ; Chemistry, Organic
研究领域[WOS]: Pharmacology & Pharmacy ; Chemistry
关键词[WOS]: THYMIDYLATE SYNTHASE INHIBITORS ; CANCER
英文摘要:

A series of 4(3H)-quinazolinone derivatives with dithiocarbamate side chains were synthesized and tested for their in vitro antitumor activity against human myelogenous leukemia K562 cells. Among them, (3,4-dihydro-2-methyl-4-oxoquinazolin-6-yl)methyl 4-(4-fluorophenyl)piperazine-1-carbodithioate 8q exhibited significant inhibitory activity against K562 cells with IC50 value of 0.5 mu M. (c) 2005 Elsevier Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000228125300030
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52392
Appears in Collections:北京大学药学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Tsing Hua Univ, Dept Chem, Beijing 100084, Peoples R China
2.Capital Normal Univ, Dept Chem, Beijing 100037, Peoples R China
3.Peking Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China

Recommended Citation:
Cao, SL,Feng, YP,Jiang, YY,et al. Synthesis and in vitro antitumor activity of 4(3H)-quinazolinone derivatives with dithiocarbamate side chains[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2005,15(7):1915-1917.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Cao, SL]'s Articles
[Feng, YP]'s Articles
[Jiang, YY]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Cao, SL]‘s Articles
[Feng, YP]‘s Articles
[Jiang, YY]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace