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Synthesis and in vitro antitumor activity of 4(3H)-quinazolinone derivatives with dithiocarbamate side chains
Cao, SL1; Feng, YP1; Jiang, YY1; Liu, SY1; Ding, GY1; Li, RT1
关键词4(3h)-quinazolinone Dithiocarbamate Antitumor Activity K562 Cells
刊名BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
2005-04-01
DOI10.1016/j.bmcl.2005.01.083
15期:7页:1915-1917
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal ; Chemistry, Organic
研究领域[WOS]Pharmacology & Pharmacy ; Chemistry
关键词[WOS]THYMIDYLATE SYNTHASE INHIBITORS ; CANCER
英文摘要

A series of 4(3H)-quinazolinone derivatives with dithiocarbamate side chains were synthesized and tested for their in vitro antitumor activity against human myelogenous leukemia K562 cells. Among them, (3,4-dihydro-2-methyl-4-oxoquinazolin-6-yl)methyl 4-(4-fluorophenyl)piperazine-1-carbodithioate 8q exhibited significant inhibitory activity against K562 cells with IC50 value of 0.5 mu M. (c) 2005 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000228125300030
Citation statistics
Cited Times:221[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52392
Collection北京大学药学院
作者单位1.Tsing Hua Univ, Dept Chem, Beijing 100084, Peoples R China
2.Capital Normal Univ, Dept Chem, Beijing 100037, Peoples R China
3.Peking Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
Recommended Citation
GB/T 7714
Cao, SL,Feng, YP,Jiang, YY,et al. Synthesis and in vitro antitumor activity of 4(3H)-quinazolinone derivatives with dithiocarbamate side chains[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2005,15(7):1915-1917.
APA Cao, SL,Feng, YP,Jiang, YY,Liu, SY,Ding, GY,&Li, RT.(2005).Synthesis and in vitro antitumor activity of 4(3H)-quinazolinone derivatives with dithiocarbamate side chains.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,15(7),1915-1917.
MLA Cao, SL,et al."Synthesis and in vitro antitumor activity of 4(3H)-quinazolinone derivatives with dithiocarbamate side chains".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 15.7(2005):1915-1917.
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