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学科主题: 临床医学
题名:
Prognostic Significance of Preoperative Albumin-Globulin Ratio in Patients with Upper Tract Urothelial Carcinoma
作者: Zhang, Bo1,2,3; Yu, Wei1,2,3; Zhou, Li-Qun1,2,3; He, Zhi-Song1,2,3; Shen, Cheng1,2,3; He, Qun1,2,3; Li, Jun1,2,3; Liu, Li-Bo1,2,3; Wang, Cong4; Chen, Xiao-Yu4; Fan, Yu1,2,3; Hu, Shuai1,2,3; Zhang, Lei1,2,3; Han, Wen-Ke1,2,3; Jin, Jie1,2,3
刊名: PLOS ONE
发表日期: 2015-12-17
DOI: 10.1371/journal.pone.0144961
卷: 10, 期:12
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: UPPER URINARY-TRACT ; SYSTEMIC INFLAMMATORY RESPONSE ; LONG-TERM MORTALITY ; C-REACTIVE PROTEIN ; CANCER-PATIENTS ; RADICAL NEPHROURETERECTOMY ; CLINICAL-SIGNIFICANCE ; ARISTOLOCHIC ACID ; PREDICT SURVIVAL ; LYMPHOCYTE RATIO
英文摘要:

Background

Preoperative albumin-globulin ratio (AGR) reflects both malnutrition and systemic inflammation in cancer patients. In particular, systemic inflammation has been reported to contribute to tumor progression and poor oncological outcome in various malignancies. However, the prognostic value of preoperative AGR in upper tract urothelial carcinoma (UTUC) has not been examined.

Methods

We retrospectively reviewed medical data of 187 operable UTUC patients in a Chinese cohort with a high incidence of chronic kidney disease (CKD). AGR was calculated as [AGR = albumin/(serum total protein-albumin)]. The associations of preoperative AGR with clinicopathologic characteristics and prognosis were assessed. Multivariate analyses using Cox regression models were performed to determine the independent prognostic factors.

Results

The median (IQR) preoperative AGR was 1.50 (1.30-1.70), and the optimal cutoff value was determined to be 1.45 according to the receiver operating curve analysis. Low AGR was significantly associated with female gender, high CKD stage and tumor grade (P < 0.05). Eighty-three patients died before the follow-up endpoint. Kaplan-Meier analysis showed that an AGR < 1.45 predicted significantly poorer overall and cancer-specific survivals compared to an AGR >= 1.45 (P < 0.001 and P = 0.008, respectively). Multivariate analyses showed that an AGR < 1.45 was an independent risk factor for poorer overall and cancer-specific survivals (P = 0.002 and P = 0.015, respectively).

Conclusions

Preoperative AGR can act as an effective biomarker with easy accessibility for evaluating the prognosis of patients with UTUC. AGR should be applied in UTUC patients for risk stratification and determination of optimal therapeutic regimens.

语种: 英语
所属项目编号: 81200548
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000366723400036
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52395
Appears in Collections:北京大学第一临床医学院_泌尿外科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Dept Urol, Beijing 100871, Peoples R China
2.Peking Univ, Inst Urol, Beijing 100871, Peoples R China
3.Natl Urol Canc Ctr, Beijing, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Beijing 100871, Peoples R China

Recommended Citation:
Zhang, Bo,Yu, Wei,Zhou, Li-Qun,et al. Prognostic Significance of Preoperative Albumin-Globulin Ratio in Patients with Upper Tract Urothelial Carcinoma[J]. PLOS ONE,2015,10(12).
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