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学科主题临床医学
Prognostic Significance of Preoperative Albumin-Globulin Ratio in Patients with Upper Tract Urothelial Carcinoma
Zhang, Bo1,2,3; Yu, Wei1,2,3; Zhou, Li-Qun1,2,3; He, Zhi-Song1,2,3; Shen, Cheng1,2,3; He, Qun1,2,3; Li, Jun1,2,3; Liu, Li-Bo1,2,3; Wang, Cong4; Chen, Xiao-Yu4; Fan, Yu1,2,3; Hu, Shuai1,2,3; Zhang, Lei1,2,3; Han, Wen-Ke1,2,3; Jin, Jie1,2,3
刊名PLOS ONE
2015-12-17
DOI10.1371/journal.pone.0144961
10期:12
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]UPPER URINARY-TRACT ; SYSTEMIC INFLAMMATORY RESPONSE ; LONG-TERM MORTALITY ; C-REACTIVE PROTEIN ; CANCER-PATIENTS ; RADICAL NEPHROURETERECTOMY ; CLINICAL-SIGNIFICANCE ; ARISTOLOCHIC ACID ; PREDICT SURVIVAL ; LYMPHOCYTE RATIO
英文摘要

Background

Preoperative albumin-globulin ratio (AGR) reflects both malnutrition and systemic inflammation in cancer patients. In particular, systemic inflammation has been reported to contribute to tumor progression and poor oncological outcome in various malignancies. However, the prognostic value of preoperative AGR in upper tract urothelial carcinoma (UTUC) has not been examined.

Methods

We retrospectively reviewed medical data of 187 operable UTUC patients in a Chinese cohort with a high incidence of chronic kidney disease (CKD). AGR was calculated as [AGR = albumin/(serum total protein-albumin)]. The associations of preoperative AGR with clinicopathologic characteristics and prognosis were assessed. Multivariate analyses using Cox regression models were performed to determine the independent prognostic factors.

Results

The median (IQR) preoperative AGR was 1.50 (1.30-1.70), and the optimal cutoff value was determined to be 1.45 according to the receiver operating curve analysis. Low AGR was significantly associated with female gender, high CKD stage and tumor grade (P < 0.05). Eighty-three patients died before the follow-up endpoint. Kaplan-Meier analysis showed that an AGR < 1.45 predicted significantly poorer overall and cancer-specific survivals compared to an AGR >= 1.45 (P < 0.001 and P = 0.008, respectively). Multivariate analyses showed that an AGR < 1.45 was an independent risk factor for poorer overall and cancer-specific survivals (P = 0.002 and P = 0.015, respectively).

Conclusions

Preoperative AGR can act as an effective biomarker with easy accessibility for evaluating the prognosis of patients with UTUC. AGR should be applied in UTUC patients for risk stratification and determination of optimal therapeutic regimens.

语种英语
WOS记录号WOS:000366723400036
项目编号81200548
资助机构National Natural Science Foundation of China
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52395
专题北京大学第一临床医学院_泌尿外科
作者单位1.Peking Univ, Hosp 1, Dept Urol, Beijing 100871, Peoples R China
2.Peking Univ, Inst Urol, Beijing 100871, Peoples R China
3.Natl Urol Canc Ctr, Beijing, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Bo,Yu, Wei,Zhou, Li-Qun,et al. Prognostic Significance of Preoperative Albumin-Globulin Ratio in Patients with Upper Tract Urothelial Carcinoma[J]. PLOS ONE,2015,10(12).
APA Zhang, Bo.,Yu, Wei.,Zhou, Li-Qun.,He, Zhi-Song.,Shen, Cheng.,...&Jin, Jie.(2015).Prognostic Significance of Preoperative Albumin-Globulin Ratio in Patients with Upper Tract Urothelial Carcinoma.PLOS ONE,10(12).
MLA Zhang, Bo,et al."Prognostic Significance of Preoperative Albumin-Globulin Ratio in Patients with Upper Tract Urothelial Carcinoma".PLOS ONE 10.12(2015).
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