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学科主题: 药学
题名:
Viewing Safety of Rare-Earth-Based Drugs from Effect of Rare Earth on Bone Metabolism
作者: Zhang Jinchao1,3; Wang Peng2; Sun Jing2; Liu Cuilian1,3; Chen Hua1,3; Huang Jian4
关键词: rare earth ions ; bone metabolism ; osteoblasts ; osteoclasts ; bone marrow stromal cells
刊名: PROGRESS IN CHEMISTRY
发表日期: 2009-05-01
卷: 21, 期:5, 页:919-928
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
关键词[WOS]: OSTEOCLAST-LIKE CELLS ; RABBIT MATURE OSTEOCLASTS ; IN-VITRO ; SUPPORT DIFFERENTIATION ; PRIMARY OSTEOBLASTS ; RESORBING ACTIVITY ; STROMAL CELLS ; MARROW ; ADIPOCYTES ; RESORPTION
英文摘要:

Some essential trace elements were reported to be involved in the normal bone metabolism. Nowadays rare earth elements are widely used in many fields and more and more rare earth elements enter the environment and food chains. They are enriched in bone and difficult to be excreted. Because the similarity between rare earth ions (Ln(3+)) and Ca(2+), they will intervene and regulate bone formation and remodeling. On one hand, rare earth are presumed to be drug candidates for bone disease; on the other hand, they have negative effects on bone metabolism. So the safety of rare-earth-based drugs deserves an answer. We review the effect of rare earth ions on bone metabolism as the following three aspects: (1) effect of rare earth ions on differentiation and function expression of osteoblasts and osteoclasts; (2) effect of rare earth ions on the osteogenic and adipogenic differentiation of bone marrow stromal cells; (3) effect of rare earth ions on bone mineral phase of animals. In addition, the scarcities and future developing perspectives in this field are also discussed.

语种: 中文
WOS记录号: WOS:000266016000015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52397
Appears in Collections:北京大学药学院_化学生物学系_期刊论文

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作者单位: 1.Hebei Univ, Affiliated Hosp, Baoding 071000, Peoples R China
2.Hebei Univ, Coll Chem & Enviromental Sci, Biol Chem Lab, Baoding 071002, Peoples R China
3.Hebei Univ, Minist Educ, Key Lab Med Chem & Mol Diag, Baoding 071002, Peoples R China
4.Peking Univ, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100083, Peoples R China

Recommended Citation:
Zhang Jinchao,Wang Peng,Sun Jing,et al. Viewing Safety of Rare-Earth-Based Drugs from Effect of Rare Earth on Bone Metabolism[J]. PROGRESS IN CHEMISTRY,2009,21(5):919-928.
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