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Viewing Safety of Rare-Earth-Based Drugs from Effect of Rare Earth on Bone Metabolism
Zhang Jinchao1,3; Wang Peng2; Sun Jing2; Liu Cuilian1,3; Chen Hua1,3; Huang Jian4
关键词Rare Earth Ions Bone Metabolism Osteoblasts Osteoclasts Bone Marrow Stromal Cells
刊名PROGRESS IN CHEMISTRY
2009-05-01
21期:5页:919-928
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary
研究领域[WOS]Chemistry
关键词[WOS]OSTEOCLAST-LIKE CELLS ; RABBIT MATURE OSTEOCLASTS ; IN-VITRO ; SUPPORT DIFFERENTIATION ; PRIMARY OSTEOBLASTS ; RESORBING ACTIVITY ; STROMAL CELLS ; MARROW ; ADIPOCYTES ; RESORPTION
英文摘要

Some essential trace elements were reported to be involved in the normal bone metabolism. Nowadays rare earth elements are widely used in many fields and more and more rare earth elements enter the environment and food chains. They are enriched in bone and difficult to be excreted. Because the similarity between rare earth ions (Ln(3+)) and Ca(2+), they will intervene and regulate bone formation and remodeling. On one hand, rare earth are presumed to be drug candidates for bone disease; on the other hand, they have negative effects on bone metabolism. So the safety of rare-earth-based drugs deserves an answer. We review the effect of rare earth ions on bone metabolism as the following three aspects: (1) effect of rare earth ions on differentiation and function expression of osteoblasts and osteoclasts; (2) effect of rare earth ions on the osteogenic and adipogenic differentiation of bone marrow stromal cells; (3) effect of rare earth ions on bone mineral phase of animals. In addition, the scarcities and future developing perspectives in this field are also discussed.

语种中文
WOS记录号WOS:000266016000015
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52397
专题北京大学药学院_化学生物学系
作者单位1.Hebei Univ, Affiliated Hosp, Baoding 071000, Peoples R China
2.Hebei Univ, Coll Chem & Enviromental Sci, Biol Chem Lab, Baoding 071002, Peoples R China
3.Hebei Univ, Minist Educ, Key Lab Med Chem & Mol Diag, Baoding 071002, Peoples R China
4.Peking Univ, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100083, Peoples R China
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Zhang Jinchao,Wang Peng,Sun Jing,et al. Viewing Safety of Rare-Earth-Based Drugs from Effect of Rare Earth on Bone Metabolism[J]. PROGRESS IN CHEMISTRY,2009,21(5):919-928.
APA Zhang Jinchao,Wang Peng,Sun Jing,Liu Cuilian,Chen Hua,&Huang Jian.(2009).Viewing Safety of Rare-Earth-Based Drugs from Effect of Rare Earth on Bone Metabolism.PROGRESS IN CHEMISTRY,21(5),919-928.
MLA Zhang Jinchao,et al."Viewing Safety of Rare-Earth-Based Drugs from Effect of Rare Earth on Bone Metabolism".PROGRESS IN CHEMISTRY 21.5(2009):919-928.
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