学科主题基础医学
CMTM3 can affect the transcription activity of androgen receptor and inhibit the expression level of PSA in LNCaP cells
Wang, Yu; Li, Ting; Qiu, Xiaoyan; Mo, Xiaoning; Zhang, Yingmei; Song, Quansheng; Ma, Dalong; Han, Wenling
关键词CMTM3 LXXLL motif AR PSA
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2008-06-20
DOI10.1016/j.bbrc.2008.03.143
371期:1页:54-58
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]CHEMOKINE-LIKE FACTOR ; MOLECULAR-CLONING ; PROSTATE-CANCER ; IDENTIFICATION ; COREGULATORS ; COACTIVATOR ; SUPERFAMILY ; HOMOLOGS ; ISOFORMS ; CKLFSF2
英文摘要

CMTM is a novel family of proteins linking chemokines and TM4SF. Several members of this family are highly expressed in testes and regulate androgen receptor (AR) transcription activity. One member of this family, CMTM3, has the highest expression level in testes and contains one leucine zipper and two LXXLL motifs. As assessed with the dual-luciferase reporter assay, overexpression of CMTM3 represses AR transactivation, while knocking down it can increase AR transactivation. Moreover, CMTM3 inhibits prostate-specific antigen (PSA) expression in LNCaP cells at both mRNA and protein levels with no obvious influence on AR expression. Taken together, CMTM3 may play some roles in the maturation and maintenance of the male reproduction. (c) 2008 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000255923900011
引用统计
被引频次:21[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52399
专题北京大学基础医学院_北京大学人类疾病基因研究中心
北京大学基础医学院
北京大学第三临床医学院_儿科
作者单位Peking Univ, Ctr Human Dis Genom, Sch Basic Med Sci, Dept Immunol, Beijing 100083, Peoples R China
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GB/T 7714
Wang, Yu,Li, Ting,Qiu, Xiaoyan,et al. CMTM3 can affect the transcription activity of androgen receptor and inhibit the expression level of PSA in LNCaP cells[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2008,371(1):54-58.
APA Wang, Yu.,Li, Ting.,Qiu, Xiaoyan.,Mo, Xiaoning.,Zhang, Yingmei.,...&Han, Wenling.(2008).CMTM3 can affect the transcription activity of androgen receptor and inhibit the expression level of PSA in LNCaP cells.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,371(1),54-58.
MLA Wang, Yu,et al."CMTM3 can affect the transcription activity of androgen receptor and inhibit the expression level of PSA in LNCaP cells".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 371.1(2008):54-58.
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