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学科主题: 基础医学
题名:
CMTM3 can affect the transcription activity of androgen receptor and inhibit the expression level of PSA in LNCaP cells
作者: Wang, Yu; Li, Ting; Qiu, Xiaoyan; Mo, Xiaoning; Zhang, Yingmei; Song, Quansheng; Ma, Dalong; Han, Wenling
关键词: CMTM3 ; LXXLL motif ; AR ; PSA
刊名: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
发表日期: 2008-06-20
DOI: 10.1016/j.bbrc.2008.03.143
卷: 371, 期:1, 页:54-58
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: CHEMOKINE-LIKE FACTOR ; MOLECULAR-CLONING ; PROSTATE-CANCER ; IDENTIFICATION ; COREGULATORS ; COACTIVATOR ; SUPERFAMILY ; HOMOLOGS ; ISOFORMS ; CKLFSF2
英文摘要:

CMTM is a novel family of proteins linking chemokines and TM4SF. Several members of this family are highly expressed in testes and regulate androgen receptor (AR) transcription activity. One member of this family, CMTM3, has the highest expression level in testes and contains one leucine zipper and two LXXLL motifs. As assessed with the dual-luciferase reporter assay, overexpression of CMTM3 represses AR transactivation, while knocking down it can increase AR transactivation. Moreover, CMTM3 inhibits prostate-specific antigen (PSA) expression in LNCaP cells at both mRNA and protein levels with no obvious influence on AR expression. Taken together, CMTM3 may play some roles in the maturation and maintenance of the male reproduction. (c) 2008 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000255923900011
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52399
Appears in Collections:基础医学院_北京大学人类疾病基因研究中心_期刊论文

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作者单位: Peking Univ, Ctr Human Dis Genom, Sch Basic Med Sci, Dept Immunol, Beijing 100083, Peoples R China

Recommended Citation:
Wang, Yu,Li, Ting,Qiu, Xiaoyan,et al. CMTM3 can affect the transcription activity of androgen receptor and inhibit the expression level of PSA in LNCaP cells[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2008,371(1):54-58.
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