|Escin improves sperm quality in male patients with varicocele-associated infertility|
|Fang, Yujiang1,2; Zhao, Lei3; Yan, Feng4; Xia, Xiaoyan5; Xu, Donghui3; Cui, Xijun6|
|关键词||Escin Aesculus Hippocastanum Infertility Varicocele|
|WOS标题词||Science & Technology|
|类目[WOS]||Plant Sciences ; Chemistry, Medicinal ; Integrative & Complementary Medicine ; Pharmacology & Pharmacy|
|研究领域[WOS]||Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine|
|关键词[WOS]||CHRONIC VENOUS INSUFFICIENCY ; PART II ; OLIGOASTHENOSPERMIA ; PATHOPHYSIOLOGY ; FERTILITY ; THERAPY ; EDEMA ; LIGHT|
Purpose: To evaluate the efficacy of escin to improve sperm quality in Chinese male patients with varicocele-associated infertility.
Methods: This study included 219 male patients with varicocele-associated infertility. These patients were randomly assigned into three groups: the control, the surgery and the escin group. 106 patients, with a mean age of 30 years old and a mean period of infertility of 5.0 years, were recruited in the escin group and a daily dose of 60 mg (30 mg every 12 h) of escin was administered orally during an uninterrupted period of 2 months. The diameter of spermatic vein was also measured using color Doppler ultrasonography before and after treatment in the escin group. Patients in all groups took composite medicines favorable for sperm quality and semen were obtained and analyzed before and after treatment.
Results: In response to treatment, the improvement rates in sperm density in the control, the surgery and the escin group, were 38.5%, 68.8%, and 57.5%, respectively. The differences in the surgery and the escin groups were significant compared to that in the control group (68.8% or 57.5% vs. 38.5%, P < 0.05). The improvement rates in sperm motility in the control, the surgery and the escin group were 46.2%, 77.1%, and 55.7%, respectively. Significant difference was only observed between the surgery and the control group (77.1% vs. 46.2%, P < 0.05). In the escin group, when severity of varicocele was classified to mild, moderate or severe degree according to the diameter of the spermatic vein, the improvement rates in disease severity were higher in the mild (41.7% vs. 20.0%, P < 0.05) and moderate severity subgroups (64.4% vs. 20.0%, P < 0.05) when compared to that in the severe subgroup (20.0%). The improvement rate in disease severity was also higher in the moderate subgroup when compared to that in the mild subgroup (64.4% vs. 41.7%, P < 0.05). During the period of treatment, only very low frequencies of mild adverse effects were observed, most of which resolved without further symptomatic drug therapy after advising the patients to take escin after meal. Escin has little effect on vital signs, blood counts, liver or kidney function.
Conclusion: Escin is a safe and effective drug to improve sperm quality in Chinese male patients with varicocele-associated infertility. (C) 2009 Elsevier GmbH. All rights reserved.
|作者单位||1.Univ Missouri, Dept Internal Med, Columbia, MO 65212 USA|
2.Peking Univ, Affiliated Hosp 3, Dept Urol, Beijing 100083, Peoples R China
3.Qiqihar Med Univ, Affiliated Hosp 1, Dept Surg, Qiqihar 161006, Peoples R China
4.Wannan Med Coll, Affiliated Hosp 2, Dept Internal Med, Wuhu 241004, Peoples R China
5.Capital Univ Med Sci, Beijing Obstet & Gynecol Hosp, Beijing 100026, Peoples R China
6.Peoples Hosp Ningjin, Dept Surg, Ningjin 253400, Peoples R China
|Fang, Yujiang,Zhao, Lei,Yan, Feng,et al. Escin improves sperm quality in male patients with varicocele-associated infertility[J]. PHYTOMEDICINE,2010,17(3-4):192-196.|
|APA||Fang, Yujiang,Zhao, Lei,Yan, Feng,Xia, Xiaoyan,Xu, Donghui,&Cui, Xijun.(2010).Escin improves sperm quality in male patients with varicocele-associated infertility.PHYTOMEDICINE,17(3-4),192-196.|
|MLA||Fang, Yujiang,et al."Escin improves sperm quality in male patients with varicocele-associated infertility".PHYTOMEDICINE 17.3-4(2010):192-196.|