|Tea Drinking as a Risk Factor for Neural Tube Defects in Northern China|
|Ye, Rongwei1,2,3; Ren, Aiguo1,2; Zhang, Le1,2; Li, Zhiwen1,2; Liu, Jianmeng1,2; Pei, Lijun4; Zheng, Xiaoying4|
|收录类别||SCI ; SSCI|
|WOS标题词||Science & Technology|
|类目[WOS]||Public, Environmental & Occupational Health|
|研究领域[WOS]||Public, Environmental & Occupational Health|
|关键词[WOS]||FOLATE LEVELS ; FOLIC-ACID ; CATECHINS ; PREVENTION ; GREEN ; INHIBITION ; PREVALENCE ; METABOLISM ; EXTRACTS ; VITAMIN|
Background: Tea catechins inhibit the activity of the enzyme dihydrofolate reductase, which catalyzes the inactive form of folate 7,8-dihydrofolate to the active form of folate 5,6,7,8-tetrahydrofolate. This inhibition leads to disturbance of the folate metabolic pathway and to lower bioavailability of folate to cells; therefore, it may increase the risk of neural tube defects (NTDs) in a developing embryo. We examined the association between tea drinking during the periconceptional period and the risk of NTDs.
Methods: Cases were fetuses or neonates with an NTD as ascertained through a population-based surveillance system in 4 rural counties of Shanxi Province in northern China during 2002 through 2007. Controls were term infants without congenital malformations. Demographic, reproductive, and exposure data were obtained through a face-to-face interview.
Results: A total of 631 NTD cases and 857 controls were included in the analysis. Compared with women who did not drink tea during the periconceptional period (487 cases and 688 controls), women who drank tea daily (20 cases and 9 controls) had a 3-fold increased risk (odds ratio = 3.1 [95% confidence interval = 1.4-7.0]) of having an NTD-affected pregnancy. The elevated risk associated with daily tea drinking remained after adjusting for maternal age, educational level, occupation, and periconceptional folic acid supplementation (3.4 [1.4-8.3]). The association was present for all 3 major subtypes of NTDs (ie, anencephaly, spina bifida, and encephalocele).
Conclusions: Daily tea drinking during the periconceptional period was associated with an elevated risk of NTDs in this Chinese population.
|项目编号||2002BA709B11 ; 2007CB5119001|
|资助机构||National Key Technologies Research and Development Program ; State Key Development Program for Basic Research, People&prime ; s Republic of China|
|作者单位||1.Peking Univ, Hlth Sci Ctr, Inst Reprod & Child Hlth, Beijing 100191, Peoples R China|
2.Peking Univ, Hlth Sci Ctr, Minist Hlth, Reference Lab Reprod Hlth, Beijing 100191, Peoples R China
3.Peking Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100191, Peoples R China
4.Peking Univ, WHO Collaborating Ctr Reprod Hlth & Populat Sci, Inst Populat Res, Beijing 100191, Peoples R China
|Ye, Rongwei,Ren, Aiguo,Zhang, Le,et al. Tea Drinking as a Risk Factor for Neural Tube Defects in Northern China[J]. EPIDEMIOLOGY,2011,22(4):491-496.|
|APA||Ye, Rongwei.,Ren, Aiguo.,Zhang, Le.,Li, Zhiwen.,Liu, Jianmeng.,...&Zheng, Xiaoying.(2011).Tea Drinking as a Risk Factor for Neural Tube Defects in Northern China.EPIDEMIOLOGY,22(4),491-496.|
|MLA||Ye, Rongwei,et al."Tea Drinking as a Risk Factor for Neural Tube Defects in Northern China".EPIDEMIOLOGY 22.4(2011):491-496.|