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Tea Drinking as a Risk Factor for Neural Tube Defects in Northern China
Ye, Rongwei1,2,3; Ren, Aiguo1,2; Zhang, Le1,2; Li, Zhiwen1,2; Liu, Jianmeng1,2; Pei, Lijun4; Zheng, Xiaoying4
刊名EPIDEMIOLOGY
2011-07-01
DOI10.1097/EDE.0b013e31821b4526
22期:4页:491-496
收录类别SCI ; SSCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Public, Environmental & Occupational Health
研究领域[WOS]Public, Environmental & Occupational Health
关键词[WOS]FOLATE LEVELS ; FOLIC-ACID ; CATECHINS ; PREVENTION ; GREEN ; INHIBITION ; PREVALENCE ; METABOLISM ; EXTRACTS ; VITAMIN
英文摘要

Background: Tea catechins inhibit the activity of the enzyme dihydrofolate reductase, which catalyzes the inactive form of folate 7,8-dihydrofolate to the active form of folate 5,6,7,8-tetrahydrofolate. This inhibition leads to disturbance of the folate metabolic pathway and to lower bioavailability of folate to cells; therefore, it may increase the risk of neural tube defects (NTDs) in a developing embryo. We examined the association between tea drinking during the periconceptional period and the risk of NTDs.

Methods: Cases were fetuses or neonates with an NTD as ascertained through a population-based surveillance system in 4 rural counties of Shanxi Province in northern China during 2002 through 2007. Controls were term infants without congenital malformations. Demographic, reproductive, and exposure data were obtained through a face-to-face interview.

Results: A total of 631 NTD cases and 857 controls were included in the analysis. Compared with women who did not drink tea during the periconceptional period (487 cases and 688 controls), women who drank tea daily (20 cases and 9 controls) had a 3-fold increased risk (odds ratio = 3.1 [95% confidence interval = 1.4-7.0]) of having an NTD-affected pregnancy. The elevated risk associated with daily tea drinking remained after adjusting for maternal age, educational level, occupation, and periconceptional folic acid supplementation (3.4 [1.4-8.3]). The association was present for all 3 major subtypes of NTDs (ie, anencephaly, spina bifida, and encephalocele).

Conclusions: Daily tea drinking during the periconceptional period was associated with an elevated risk of NTDs in this Chinese population.

语种英语
WOS记录号WOS:000291252100010
项目编号2002BA709B11 ; 2007CB5119001
资助机构National Key Technologies Research and Development Program ; State Key Development Program for Basic Research, People&prime ; s Republic of China
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52403
专题北京大学公共卫生学院
北京大学医学部管理机构_医学部
北京大学公共卫生学院_卫计委生育健康重点实验室
作者单位1.Peking Univ, Hlth Sci Ctr, Inst Reprod & Child Hlth, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Minist Hlth, Reference Lab Reprod Hlth, Beijing 100191, Peoples R China
3.Peking Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100191, Peoples R China
4.Peking Univ, WHO Collaborating Ctr Reprod Hlth & Populat Sci, Inst Populat Res, Beijing 100191, Peoples R China
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GB/T 7714
Ye, Rongwei,Ren, Aiguo,Zhang, Le,et al. Tea Drinking as a Risk Factor for Neural Tube Defects in Northern China[J]. EPIDEMIOLOGY,2011,22(4):491-496.
APA Ye, Rongwei.,Ren, Aiguo.,Zhang, Le.,Li, Zhiwen.,Liu, Jianmeng.,...&Zheng, Xiaoying.(2011).Tea Drinking as a Risk Factor for Neural Tube Defects in Northern China.EPIDEMIOLOGY,22(4),491-496.
MLA Ye, Rongwei,et al."Tea Drinking as a Risk Factor for Neural Tube Defects in Northern China".EPIDEMIOLOGY 22.4(2011):491-496.
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