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学科主题: 药物依赖
题名:
Effects of cocaine and cocaine metabolites on cardiovascular function in squirrel monkeys
作者: Schindler, CW1; Zheng, JW1; Goldberg, SR1
关键词: cocaine ; cocaine metabolites ; blood pressure ; heart rate ; squirrel monkeys
刊名: EUROPEAN JOURNAL OF PHARMACOLOGY
发表日期: 2001-11-09
卷: 431, 期:1, 页:53-59
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: ANESTHETIZED RATS ; CONSCIOUS RATS ; IN-VITRO ; COCAETHYLENE ; HUMANS ; TOXICITY ; PHARMACOKINETICS ; VASOCONSTRICTION ; PHARMACOLOGY ; NORCOCAINE
英文摘要:

The effects of cocaine and the cocaine metabolites norcocaine, ecgonine methyl ester, benzoylecgonine and cocaethylene were evaluated in conscious squirrel monkeys for their effects on blood pressure and heart rate. Norcocaine, ecgonine methyl ester and benzoylecgonine are produced in vivo following cocaine use. Cocaethylene is produced in vivo following concurrent cocaine and alcohol use. Increases in both blood pressure and heart rate were observed following cocaine doses of 0.3-3.0 mg/kg. Ecgonine methyl ester and benzoylecgonine had no effect on either parameter up to doses of 10.0 mg/kg. Norcocaine increased blood pressure, but was less potent than cocaine. Norcocaine did not affect heart rate at doses up to 3.0 mg/kg. In contrast to the other metabolites, cocaethylene increased blood pressure and heart rate similarly to cocaine, These results suggest that ecgonine methyl ester and benzoylecgonine are devoid of cardiovascular effects at doses comparable to cocaine and would not be expected to contribute to cocaine′s overall cardiovascular effects. Norcocaine′s effect on blood pressure might contribute to the cardiovascular effects of cocaine. but this metabolite is produced only at low levels in vivo. The one metabolite that might be expected to contribute to cocaine′s overall cardiovascular effect is cocaethylene, although the degree of this contribution is not clear. Published by Elsevier Science B.V.

语种: 英语
WOS记录号: WOS:000172388400008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52411
Appears in Collections:中国药物依赖性研究所_期刊论文

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作者单位: 1.NIDA, Preclin Pharmacol Sect, Intramural Res Program, NIH, Baltimore, MD 21224 USA
2.Beijing Med Univ, Natl Inst Drug Dependence, Beijing 100083, Peoples R China

Recommended Citation:
Schindler, CW,Zheng, JW,Goldberg, SR. Effects of cocaine and cocaine metabolites on cardiovascular function in squirrel monkeys[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2001,431(1):53-59.
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