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Effects of cocaine and cocaine metabolites on cardiovascular function in squirrel monkeys
Schindler, CW()1; Zheng, JW()1; Goldberg, SR()1
关键词Cocaine Cocaine Metabolites Blood Pressure Heart Rate Squirrel Monkeys
刊名EUROPEAN JOURNAL OF PHARMACOLOGY
2001-11-09
431期:1页:53-59
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]ANESTHETIZED RATS ; CONSCIOUS RATS ; IN-VITRO ; COCAETHYLENE ; HUMANS ; TOXICITY ; PHARMACOKINETICS ; VASOCONSTRICTION ; PHARMACOLOGY ; NORCOCAINE
英文摘要

The effects of cocaine and the cocaine metabolites norcocaine, ecgonine methyl ester, benzoylecgonine and cocaethylene were evaluated in conscious squirrel monkeys for their effects on blood pressure and heart rate. Norcocaine, ecgonine methyl ester and benzoylecgonine are produced in vivo following cocaine use. Cocaethylene is produced in vivo following concurrent cocaine and alcohol use. Increases in both blood pressure and heart rate were observed following cocaine doses of 0.3-3.0 mg/kg. Ecgonine methyl ester and benzoylecgonine had no effect on either parameter up to doses of 10.0 mg/kg. Norcocaine increased blood pressure, but was less potent than cocaine. Norcocaine did not affect heart rate at doses up to 3.0 mg/kg. In contrast to the other metabolites, cocaethylene increased blood pressure and heart rate similarly to cocaine, These results suggest that ecgonine methyl ester and benzoylecgonine are devoid of cardiovascular effects at doses comparable to cocaine and would not be expected to contribute to cocaine′s overall cardiovascular effects. Norcocaine′s effect on blood pressure might contribute to the cardiovascular effects of cocaine. but this metabolite is produced only at low levels in vivo. The one metabolite that might be expected to contribute to cocaine′s overall cardiovascular effect is cocaethylene, although the degree of this contribution is not clear. Published by Elsevier Science B.V.

语种英语
WOS记录号WOS:000172388400008
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被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52411
专题中国药物依赖性研究所
作者单位1.NIDA, Preclin Pharmacol Sect, Intramural Res Program, NIH, Baltimore, MD 21224 USA
2.Beijing Med Univ, Natl Inst Drug Dependence, Beijing 100083, Peoples R China
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Schindler, CW,Zheng, JW,Goldberg, SR. Effects of cocaine and cocaine metabolites on cardiovascular function in squirrel monkeys[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2001,431(1):53-59.
APA Schindler, CW,Zheng, JW,&Goldberg, SR.(2001).Effects of cocaine and cocaine metabolites on cardiovascular function in squirrel monkeys.EUROPEAN JOURNAL OF PHARMACOLOGY,431(1),53-59.
MLA Schindler, CW,et al."Effects of cocaine and cocaine metabolites on cardiovascular function in squirrel monkeys".EUROPEAN JOURNAL OF PHARMACOLOGY 431.1(2001):53-59.
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