IR@PKUHSC  > 北京大学第二临床医学院  > 血液科
学科主题临床医学
Promotion of Nerve Regeneration in Peripheral Nerve by Short-Course FK506 after End-to-Side Neurorrhaphy
Chen, Bin1; Song, Youxin2; Liu, Zhongjun1
关键词Peripheral Nerve End-to-side Neurorrhaphy Regeneration Short-course Fk506
刊名JOURNAL OF SURGICAL RESEARCH
2009-04-01
DOI10.1016/j.jss.2008.03.032
152期:2页:303-310
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Surgery
研究领域[WOS]Surgery
关键词[WOS]FUNCTIONAL ASSESSMENT ; COAPTATION ; REPAIR ; RATS ; REINNERVATION ; MOTOR ; IMMUNOSUPPRESSION ; TRANSPLANTATION ; ANASTOMOSIS ; TACROLIMUS
英文摘要

Background/Aims. To discuss the feasibility of peripheral nerve injury treated by end-to-side neurorrhaphy in clinic and to evaluate the effect of short-course FK506 on promoting nerve regeneration after end-to-side neurorrhaphy.

Methods. Thirty adult male Sprague Dawley rats were randomly divided into 3 groups: Group A, 10 rats received end-to-end anastomosis; Group B, 10 rats received end-to-side neurorrhaphy; Group C, 10 rats received the same operation as Group B. After operation, rats in Groups B and C received muscle injection with saline water (1 mg/kg.d(-1)) and FK506 (1 mg/kg.d(-1)), respectively, both for 4 wk. Histological and morphological examinations were performed 12 wk after the operation. In the 2nd, 4th, 6th, Sth, and 12th wk after operation, function recovery analysis was performed.

Results. The results of histological and immunochemistry study (the total number of Schwann cells and the axon numbers at the distal stump of the peroneal nerve, wet weight of extensor digitorum longus muscle) suggested that there were significant differences between Group B (saline water group) and Group C (FK506 group) (P < 0.05), also between Group A (end-to-end group) and Group C (P < 0.05). There were statistically significant differences in function recovery (peroneal functional index and sciatic functional index) between Groups B and C (P < 0.05) and also between Groups A and C (P < 0.05).

Conclusion. End-to-side repair combined with FX506 has a potential for application in selected cases of peripheral nerve injury in clinic. (C) 2009 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000264501700017
引用统计
被引频次:22[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52415
专题北京大学第二临床医学院_血液科
北京大学第三临床医学院_骨科
作者单位1.Peking Univ, Dept Orthoped, Hosp 3, Beijing 100871, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Trauma & Orthoped, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Chen, Bin,Song, Youxin,Liu, Zhongjun. Promotion of Nerve Regeneration in Peripheral Nerve by Short-Course FK506 after End-to-Side Neurorrhaphy[J]. JOURNAL OF SURGICAL RESEARCH,2009,152(2):303-310.
APA Chen, Bin,Song, Youxin,&Liu, Zhongjun.(2009).Promotion of Nerve Regeneration in Peripheral Nerve by Short-Course FK506 after End-to-Side Neurorrhaphy.JOURNAL OF SURGICAL RESEARCH,152(2),303-310.
MLA Chen, Bin,et al."Promotion of Nerve Regeneration in Peripheral Nerve by Short-Course FK506 after End-to-Side Neurorrhaphy".JOURNAL OF SURGICAL RESEARCH 152.2(2009):303-310.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Chen, Bin]的文章
[Song, Youxin]的文章
[Liu, Zhongjun]的文章
百度学术
百度学术中相似的文章
[Chen, Bin]的文章
[Song, Youxin]的文章
[Liu, Zhongjun]的文章
必应学术
必应学术中相似的文章
[Chen, Bin]的文章
[Song, Youxin]的文章
[Liu, Zhongjun]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。