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学科主题: 临床医学
题名:
Promotion of Nerve Regeneration in Peripheral Nerve by Short-Course FK506 after End-to-Side Neurorrhaphy
作者: Chen, Bin1; Song, Youxin2; Liu, Zhongjun1
关键词: peripheral nerve ; end-to-side neurorrhaphy ; regeneration ; short-course ; FK506
刊名: JOURNAL OF SURGICAL RESEARCH
发表日期: 2009-04-01
DOI: 10.1016/j.jss.2008.03.032
卷: 152, 期:2, 页:303-310
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Surgery
研究领域[WOS]: Surgery
关键词[WOS]: FUNCTIONAL ASSESSMENT ; COAPTATION ; REPAIR ; RATS ; REINNERVATION ; MOTOR ; IMMUNOSUPPRESSION ; TRANSPLANTATION ; ANASTOMOSIS ; TACROLIMUS
英文摘要:

Background/Aims. To discuss the feasibility of peripheral nerve injury treated by end-to-side neurorrhaphy in clinic and to evaluate the effect of short-course FK506 on promoting nerve regeneration after end-to-side neurorrhaphy.

Methods. Thirty adult male Sprague Dawley rats were randomly divided into 3 groups: Group A, 10 rats received end-to-end anastomosis; Group B, 10 rats received end-to-side neurorrhaphy; Group C, 10 rats received the same operation as Group B. After operation, rats in Groups B and C received muscle injection with saline water (1 mg/kg.d(-1)) and FK506 (1 mg/kg.d(-1)), respectively, both for 4 wk. Histological and morphological examinations were performed 12 wk after the operation. In the 2nd, 4th, 6th, Sth, and 12th wk after operation, function recovery analysis was performed.

Results. The results of histological and immunochemistry study (the total number of Schwann cells and the axon numbers at the distal stump of the peroneal nerve, wet weight of extensor digitorum longus muscle) suggested that there were significant differences between Group B (saline water group) and Group C (FK506 group) (P < 0.05), also between Group A (end-to-end group) and Group C (P < 0.05). There were statistically significant differences in function recovery (peroneal functional index and sciatic functional index) between Groups B and C (P < 0.05) and also between Groups A and C (P < 0.05).

Conclusion. End-to-side repair combined with FX506 has a potential for application in selected cases of peripheral nerve injury in clinic. (C) 2009 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000264501700017
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52415
Appears in Collections:北京大学第三临床医学院_骨科_期刊论文

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作者单位: 1.Peking Univ, Dept Orthoped, Hosp 3, Beijing 100871, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Trauma & Orthoped, Beijing 100871, Peoples R China

Recommended Citation:
Chen, Bin,Song, Youxin,Liu, Zhongjun. Promotion of Nerve Regeneration in Peripheral Nerve by Short-Course FK506 after End-to-Side Neurorrhaphy[J]. JOURNAL OF SURGICAL RESEARCH,2009,152(2):303-310.
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