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Radioimmunotherapy of Human Colon Cancer Xenografts with I-131-Labeled Anti-CEA Monoclonal Antibody
Liu, Zhaofei; Jin, Cunjing; Yu, Zilin; Zhang, Jing; Liu, Yan; Zhao, Huiyun; Jia, Bing; Wang, Fan
刊名BIOCONJUGATE CHEMISTRY
2010-02-01
DOI10.1021/bc9003603
21期:2页:314-318
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemical Research Methods ; Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary ; Chemistry, Organic
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]COLORECTAL-CANCER ; IN-VITRO ; THERAPY ; TUMORS ; LOCALIZATION ; LYMPHOMA ; MICE ; LA22
英文摘要

Radioimmunotherapy (RIT) is a promising approach for the treatment of a wide variety of malignancies. The aim of this study was to investigate the therapeutic efficacy of I-131-labeled anticarcinoembryonic antigen (CEA) monoclonal antibody CL58 in a human colon cancer mouse model. In vitro and in vivo characteristics of I-125-CL58 were evaluated in LS180 human colon cancer cells and the nude mouse model. I-131-CL58 was prepared and its in vivo therapeutic efficacy was tested. I-125-CL58 showed high affinity to LS 180 cells, as well as high tumor uptake and long tumor retention in LS180 tumor xenografts. I-131-CL58 exhibited dose-dependent inhibition of LS180 tumor growth. With the excellent in vitro and in vivo characteristics, and the effective therapy for colon cancer in animal model, I-131-CL58 is a promising agent for RIT of CEA-positive tumors including colon cancer.

语种英语
WOS记录号WOS:000274514300016
项目编号2009ZX09103733 ; 2009ZX09103-746 ; 2009ZX09301-010 ; 30640067 ; 30870728 ; 30930030 ; 30900373 ; 20820102035 ; 2007AA02Z467
资助机构Ministry of Science and Technology of China ; NSFC ; 863 project
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52422
专题北京大学医药卫生分析中心
北京大学基础医学院
作者单位Peking Univ, Med Isotopes Res Ctr, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Liu, Zhaofei,Jin, Cunjing,Yu, Zilin,et al. Radioimmunotherapy of Human Colon Cancer Xenografts with I-131-Labeled Anti-CEA Monoclonal Antibody[J]. BIOCONJUGATE CHEMISTRY,2010,21(2):314-318.
APA Liu, Zhaofei.,Jin, Cunjing.,Yu, Zilin.,Zhang, Jing.,Liu, Yan.,...&Wang, Fan.(2010).Radioimmunotherapy of Human Colon Cancer Xenografts with I-131-Labeled Anti-CEA Monoclonal Antibody.BIOCONJUGATE CHEMISTRY,21(2),314-318.
MLA Liu, Zhaofei,et al."Radioimmunotherapy of Human Colon Cancer Xenografts with I-131-Labeled Anti-CEA Monoclonal Antibody".BIOCONJUGATE CHEMISTRY 21.2(2010):314-318.
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