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学科主题: 药学
题名:
An efficient ionic liquid supported divergent assembly of 3,6-branched glucosamine-containing pentasaccharide
作者: Gao, Ze-Shen; Sun, Sheng; Li, Wei; Ma, Qing; Li, Qing; Li, Zhong-Jun
关键词: Ionic liquid ; Oligosaccharide ; Rapid assembling
刊名: CHINESE CHEMICAL LETTERS
发表日期: 2014-12-01
DOI: 10.1016/j.cclet.2014.09.016
卷: 25, 期:12, 页:1525-1530
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
关键词[WOS]: OLIGOSACCHARIDE SYNTHESIS ; SOLID-PHASE ; GLYCOSYLATION ; CHEMISTRY ; STRATEGY ; RELEASE ; POLYMER ; AGENTS
英文摘要:

We utilized the glycosyl acceptor tagging method with ionic liquid support for synthesis of the core segment of Clostridium botulinum C2 toxin ligand through a divergent synthetic strategy without chromatographic purification. The total yield was 57.1% and the reaction was completed in 10 h. The efficient ionic liquid supported glycosylation and purification procedure was applied for the synthesis of branched glucosamine-containing oligosaccharides for the first time, which expanded the scope of ionic liquid supported synthesis of biologically important oligosaccharides. (C) 2014 Qing Li and Zhong-Jun Li. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

语种: 英语
所属项目编号: 2012CB822100 ; 2012ZX09502001-001 ; 91213301 ; 21232002
项目资助者: National Basic Research Program of China (973 Program) ; National Key Technology R&amp ; D Program "New Drug Innovation" of China ; National Natural Science Foundation of China
WOS记录号: WOS:000348013600004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52427
Appears in Collections:北京大学药学院_期刊论文

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作者单位: Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

Recommended Citation:
Gao, Ze-Shen,Sun, Sheng,Li, Wei,et al. An efficient ionic liquid supported divergent assembly of 3,6-branched glucosamine-containing pentasaccharide[J]. CHINESE CHEMICAL LETTERS,2014,25(12):1525-1530.
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