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学科主题: 药学
题名:
Single-wall carbon nanohorns (SWNHs) inhibited proliferation of human glioma cells and promoted its apoptosis
作者: Li, Yunjun1,2; Zhang, Jinqian3; Zhao, Ming4; Shi, Zujin5; Chen, Xin4; He, Xihui4; Han, Nanyin4; Xu, Ruxiang1,2
关键词: Single-walled carbon nanohorns (SWNHs) ; Proliferation ; Apoptosis ; Glioma
刊名: JOURNAL OF NANOPARTICLE RESEARCH
发表日期: 2013-08-01
DOI: 10.1007/s11051-013-1861-5
卷: 15, 期:8
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
研究领域[WOS]: Chemistry ; Science & Technology - Other Topics ; Materials Science
关键词[WOS]: MACROPHAGE CELLS ; DRUG CARRIERS ; IN-VITRO ; NANOPARTICLES ; NANOTUBES ; TOXICITY ; ENHANCEMENT ; CONJUGATE ; CYTOPLASM ; CISPLATIN
英文摘要:

Although single-wall carbon nanohorns (SWNHs) have been demonstrated to accumulate to cytotoxic levels within organs of various animal models and cell types, they have been exploited for cancer therapies. The role of SWNHs in human glioma cell lines was unclear. To address this question, the research about direct role of SWNHs on the growth, proliferation, and apoptosis of human glioma cell lines (U87, U251, and U373) had been performed. Our results indicate that particle size of SWNHs in water is between 342 and 712 nm, the films of SEM show that SWNHs on PS surface are individual particles. SWNHs significantly delayed mitotic entry of human glioma cell lines cells, and inhibited its proliferation in a time-and dose-dependent manner. SWNHs induced a significant increase in G1 phase and inhibition of S phase followed the gradually increasing concentrations. SWNHs in human glioma cell lines cells significantly induced apoptosis followed by their gradually increasing concentrations. The TEM images showed that individual spherical SWNHs particles smaller than 100 nm in diameters were localized inside lysosomes of human glioma cell lines. SWNHs inhibited mitotic entry, growth, and proliferation of human glioma cell lines, and promoted its apoptosis. SWNHs may be a novel opportunity or method for the research on treatment of human glioma.

语种: 英语
所属项目编号: 30600524 ; 81071990 ; 81201758 ; 2012A030400055 ; 2010B080701088 ; 2011B080701096 ; 2011B031800184 ; 2011J410010 ; 2011J4300066
项目资助者: National Natural Science Foundation of China ; Science and Technology Planning Project of Guangdong Province ; Science and Technology projects of Guangzhou
WOS记录号: WOS:000322593200054
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52431
Appears in Collections:北京大学药学院_化学生物学系_期刊论文

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作者单位: 1.Mil Gen Hosp Beijing PLA, Affiliated Bayi Brain Hosp, Beijing 100700, Peoples R China
2.Med Sch Chinese PLA, Beijing 100700, Peoples R China
3.Capital Med Univ, Beijing Ditan Hosp, Inst Infect Dis, Beijing 100015, Peoples R China
4.Peking Univ, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100191, Peoples R China
5.Peking Univ, Coll Chem & Mol Engn, State Key Lab Rare Earth Mat Chem & Applicat, Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China

Recommended Citation:
Li, Yunjun,Zhang, Jinqian,Zhao, Ming,et al. Single-wall carbon nanohorns (SWNHs) inhibited proliferation of human glioma cells and promoted its apoptosis[J]. JOURNAL OF NANOPARTICLE RESEARCH,2013,15(8).
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