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学科主题: 基础医学
题名:
TCF3 inhibits F9 embryonal carcinoma growth by the down-regulation of Oct4
作者: Lin, Guimiao2,3; Zhao, Lijuan2; Yin, Feng3; Lan, Rongfeng3; Li, Lianbo3; Zhang, Xiaoming3; Zhang, Hui3; Yang, Baoxue1,2,4
关键词: embryonal carcinoma ; F9 cells ; Oct4 ; overexpression ; T-cell factor 3
刊名: ONCOLOGY REPORTS
发表日期: 2011-10-01
DOI: 10.3892/or.2011.1376
卷: 26, 期:4, 页:893-899
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: PLURIPOTENT STEM-CELLS ; SELF-RENEWAL ; TRANSCRIPTION FACTORS ; ES CELLS ; EXPRESSION ; GENE ; OCT-3/4 ; XENOPUS ; SKIN ; DIFFERENTIATION
英文摘要:

T-cell factor 3 (TCF3), a downstream effector of Wnt signaling in embryonic stem (ES) cells, plays an important role in pluripotent self-renewal and proliferation. Loss of TCF3 delays the differentiation of mouse ES cells. The purpose of this study was to investigate the effect of TCF3 on embryonal carcinoma (EC). The mouse F9 EC cell line and a tumor-bearing mouse model were used to evaluate the anti-EC tumor effects of TCF3 in vitro and in vivo, respectively. The overexpression of TCF3 significantly inhibited proliferation, colony-forming and migration in F9 EC cells by approximately 30, 45 and 30%, respectively. The in vivo mouse model showed that the overexpression of TCF3 significantly reduced tumor volume (36.4%) and tumor weight (34.8%), malignancy progression and local infiltration and prolonged the life span of tumor-bearing mice. Overexpression of TCF3 significantly down-regulated Oct4 expression in the F9 EC cells. The results indicate that TCF3 is an inhibitor of the malignant phenotypes of embryonal carcinoma through the regulation of Oct4 expression.

语种: 英语
所属项目编号: 3030231 ; 30870921 ; 201015195
项目资助者: National Natural Science Foundation of China (NSFC) ; Science and Technology Bureau of Shezhen ; Science and Technology Department of Jilin Province
WOS记录号: WOS:000294381100018
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52432
Appears in Collections:基础医学院_药理学系_期刊论文

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作者单位: 1.Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing 100191, Peoples R China
2.Peking Univ, Dept Pharmacol, Sch Basic Med Sci, Beijing 100191, Peoples R China
3.Jilin Univ, Dept Pathophysiol, Norman Bethune Med Sch, Changchun 130021, Peoples R China
4.Peking Univ, Lab Chem Genom, Shenzhen Grad Sch, Sch Chem Biol & Biotechnol, Shenzhen 518055, Peoples R China

Recommended Citation:
Lin, Guimiao,Zhao, Lijuan,Yin, Feng,et al. TCF3 inhibits F9 embryonal carcinoma growth by the down-regulation of Oct4[J]. ONCOLOGY REPORTS,2011,26(4):893-899.
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