IR@PKUHSC  > 北京大学基础医学院  > 病原生物学系
学科主题基础医学
Genetic polymorphisms of CXCR5 and CXCL13 are associated with non-responsiveness to the hepatitis B vaccine
Duan, Zhaojun1,2; Chen, Xiangmei1,2; Liang, Zhenglun3; Zeng, Ying4; Zhu, Fengcai5; Long, Lu1,2; McCrae, Malcolm A.6; Zhuang, Hui1,2; Shen, Tao1,2; Lu, Fengmin1,2
关键词Polymorphism Follicular T helper cell CXCR5 CXCL13 Hepatitis B vaccine Non-response
刊名VACCINE
2014-09-15
DOI10.1016/j.vaccine.2014.07.064
32期:41页:5316-5322
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology ; Medicine, Research & Experimental
研究领域[WOS]Immunology ; Research & Experimental Medicine
关键词[WOS]FOLLICULAR-HELPER-CELLS ; CD4 T-CELLS ; CHEMOKINE RECEPTOR ; IMMUNE-RESPONSES ; NONRESPONDERS ; IMMUNOGENICITY ; REVACCINATION ; CHILDREN ; ANTIGEN ; MEMORY
英文摘要

A cohort based study has been undertaken to investigate the possible association of genetic polymorphisms in genes functionally related to follicular T helper (TfH) cells with non-responsiveness to hepatitis B virus (HBV) vaccination. A total of 24 single nucleotide polymorphisms (SNPs) in 6 TfH related genes (CXCR5, ICOS, CXCL13, IL-21, BCL6 and CD40L) were investigated in 20 non-responders and 45 responders to HBV vaccination. Genetic association analysis revealed that three SNPs (rs497916, rs3922, rs676925) in CXCR5 and one SNP (rs355687) in CXCL13 were associated with hepatitis B vaccine efficacy. In addition, significantly unbalanced distributions of two haplotypes, defined by three SNPs (rs497916, rs3922, rs676925) within CXCR5, were also seen between non-responders and responders. Furthermore, we demonstrated that the rs3922 "GC" genotype was associated with higher levels of CXCR5 than the "AG" and "AA" genotype in a group of healthy volunteers. A dual luciferase report assay was used to confirm that the "G" allele in rs3922 may lead to higher gene expression than the "A" allele, implicating that rs3922 might be a functional SNP affecting CXCR5 expression. These results indicated that polymorphism associated changes in CXCR5 expression in TfH cells may be associated with non-responsiveness to hepatitis B vaccination. (C) 2014 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).

语种英语
WOS记录号WOS:000342272400010
项目编号2013ZX10002002 ; 2012ZX10002001 ; 81271826 ; 7122108 ; B07001
资助机构National S& ; T Major Project for Infectious Diseases ; National Natural Science Foundation of China ; Natural Science Foundation of Beijing ; 111 Project
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52433
专题北京大学基础医学院_病原生物学系
北京大学基础医学院
作者单位1.Pirbright Inst, Pirbright, England
2.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Microbiol, Beijing 100191, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Ctr Infect Dis, Sch Basic Med Sci, Beijing 100191, Peoples R China
4.Natl Inst Food & Drug Control, Dept Hepatitis Vaccine, Beijing 100050, Peoples R China
5.Shenzhen Kangtai Biol Prod Co Ltd, Dept R&D, Shenzhen 518057, Guangdong, Peoples R China
6.Jiangsu Prov Ctr Dis Control & Prevent, Nanjing 210009, Jiangsu, Peoples R China
推荐引用方式
GB/T 7714
Duan, Zhaojun,Chen, Xiangmei,Liang, Zhenglun,et al. Genetic polymorphisms of CXCR5 and CXCL13 are associated with non-responsiveness to the hepatitis B vaccine[J]. VACCINE,2014,32(41):5316-5322.
APA Duan, Zhaojun.,Chen, Xiangmei.,Liang, Zhenglun.,Zeng, Ying.,Zhu, Fengcai.,...&Lu, Fengmin.(2014).Genetic polymorphisms of CXCR5 and CXCL13 are associated with non-responsiveness to the hepatitis B vaccine.VACCINE,32(41),5316-5322.
MLA Duan, Zhaojun,et al."Genetic polymorphisms of CXCR5 and CXCL13 are associated with non-responsiveness to the hepatitis B vaccine".VACCINE 32.41(2014):5316-5322.
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